Effects of a Brussels sprouts extract on oxidative DNA damage and metabolising enzymes in rat liver

Sørensen, Mette; Jensen, B.R.; Poulsen, Henrik E.; Deng, Xin-Sheng; Tygstrup, Niels; Dalhoff, Kim; Loft, Steffen

doi:10.1016/s0278-6915(00)00170-8

Cited by 36 publications

(15 citation statements)

References 43 publications

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“…In fact, the buckwheat sprout has greater nutritional value (more amino acids, minerals, protein, polyunsaturated fatty acids and crude fibers) than the seeds or seed products ( 3 , 5 , 11 ). Several researchers have reported that the consumption of sprouts from various vegetables has beneficial health effects in experimental animals (12)(13)(14)(15). For example, Taniguchi et al ( 12 ) have suggested that the Japanese radish sprout has hypoglycemic activity and improves lipid metabolism in rats.…”

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confidence: 99%

Tartary Buckwheat Sprout Powder Lowers Plasma Cholesterol Level in Rats

Kuwabara

Han

Hashimoto

et al. 2007

J Nutr Sci Vitaminol

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Summary We examined the effects of different types of buckwheat sprouts on the plasma cholesterol concentration, fecal steroid excretion and hepatic mRNA expression related to cholesterol metabolism in rats. Rats were fed a cholesterol-free diet with 5 g of Kitawasesoba common buckwheat sprout powder (KS)/100 g, 5 g of Hokkai T no. 8 tartary buckwheat sprout powder (HS-8)/100 g or 5 g of Hokkai T no. 9 tartary buckwheat sprout powder (HS-9)/100 g of diet for 4 wk. Control rats were fed a diet with ␣ -cornstarch instead of sprout powder for 4 wk. There were no significant differences in food intake, body weight, liver weight or cecal contents among the groups. Plasma total cholesterol concentrations in the HS-8 and HS-9 groups were significantly lower than in the control group, whereas there was no significant difference between the KS and control groups. Fecal bile acid excretion and cecal short-chain fatty acid concentrations in the KS, HS-8 and HS-9 groups were significantly greater than in the control group. Furthermore, fecal matter excretion in the KS, HS-8 and HS-9 groups tended to be increased compared to the control group, with that in the HS-8 group being significantly higher than in the control group. Hepatic cholesterol 7 ␣ -hydroxylase mRNA expression in the KS, HS-8 and HS-9 groups and hepatic HMG-CoA reductase mRNA expression in the HS-9 group were significantly higher than in the control group. The results suggest that tartary buckwheat sprout powder has a serum cholesterollowering function by enhancing fecal bile acid excretion through increased fecal matter excretion or the upregulation of hepatic cholesterol 7 ␣ -hydroxylase mRNA expression in rats.

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confidence: 99%

Tartary Buckwheat Sprout Powder Lowers Plasma Cholesterol Level in Rats

Kuwabara

Han

Hashimoto

et al. 2007

J Nutr Sci Vitaminol

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“…Among all edible Brassicaceae varieties, broccoli has the strongest antiradical activity measured by the DPPH radical assay (Heimler et al, 2006). Extracts of broccoli have strong antioxidant and antitumor properties (Sørensen et al, 2001;Chun et al, 2004;Eberhardt et al, 2005). Moreover, 3 day old broccoli sprouts are commercially available in the form of pharmaceutical preparations.…”

Section: Discussionmentioning

confidence: 99%

“…2006), which are good free radical scavengers (Sørensen et al, 2001;Gülcin et al, 2004;Eberhardt et al, 2005) and thus might have strong antitumor properties (Verhoeven et al, 1997;Brandi et al, 2005). Furthermore, 3 day old broccoli seedlings contain 10 to 100 times more glucosinolate than mature plants.…”

Section: Pharmaceutical Biologymentioning

confidence: 99%

Antioxidative and antitumor properties ofin vitro-cultivated broccoli (Brassica oleraceavar.italica)

Čakar¹,

Parić

Maksimović

et al. 2012

Pharmaceutical Biology

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“…Extracts were prepared as previously described (14), with some modifications. First, the collected leaves were washed and stored in portions at -80°C.…”

Section: B Oleracea Extract Preparationmentioning

confidence: 99%

Evaluation of the Protective Effect of Brassica oleracea (L. var. acephala) in Rats with Surgically-Induced Gastroesophageal Reflux Disease

Wisnieski

Brito

Cosenza

et al. 2016

Thrita

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Background: Gastroesophageal reflux disease (GERD) is a common disorder that may result in esophageal cancer. Although proton pump inhibitors are the standard treatment for this illness, Brassica oleracea may provide new therapeutic possibilities. Objectives: We aimed to evaluate and compare the effects of the B. oleracea extract and the proton pump inhibitor omeprazole on esophageal complications arising from a surgically-induced GERD model in rats. In addition, we investigated possible associations between the frequency of DNA damage and esophageal histological alterations, as well as the genotoxic/anti-genotoxic and cytotoxic/anti-cytotoxic effects of B. oleracea and omeprazole. Methods: Rats with and without GERD were equally divided into groups to receive one of two the treatments, B. oleracea extract (500 mg/kg bw) or omeprazole (30 mg/kg bw), daily over the course of four weeks. A group of non-treated rats received water in the same circumstances. Micronucleus assay was used to assess DNA damage in blood and bone marrow cells. Results: Rats with GERD developed esophagitis and esophageal squamous cell carcinoma. B. oleracea and omeprazole-treated GERD rats presented significantly decreased inflammation in relation to non-treated GERD rats (P < 0.05). However, in rats without GERD, omeprazole significantly increased the frequencies of micronuclei and micronucleated cells as compared to the corresponding cell counts in non-treated rats (P = 0.04). Conclusions: B. oleracea demonstrated similar anti-inflammatory properties to omeprazole in rats with GERD. However, omeprazole also demonstrated genotoxic and cytotoxic effects in rats without GERD.

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Effects of a Brussels sprouts extract on oxidative DNA damage and metabolising enzymes in rat liver

Cited by 36 publications

References 43 publications

Tartary Buckwheat Sprout Powder Lowers Plasma Cholesterol Level in Rats

Tartary Buckwheat Sprout Powder Lowers Plasma Cholesterol Level in Rats

Antioxidative and antitumor properties ofin vitro-cultivated broccoli (Brassica oleraceavar.italica)

Evaluation of the Protective Effect of Brassica oleracea (L. var. acephala) in Rats with Surgically-Induced Gastroesophageal Reflux Disease

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