1997
DOI: 10.1159/000179225
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Effects of a Calcium Antagonist and of the Adrenergic System on Spontaneous Vasomotion and Mean Arteriolar Diameter in the Hamster Cheek Pouch: Influence of Buflomedil

Abstract: Intravital microscopy of the hamster cheek pouch microvasculature was used for in vivo studies of the effects of diltiazem (calcium antagonist, group I), prazosin (α1-adrenergic receptor antagonist, group III), rauwolscine (α-adrenergic receptor antagonist, group V), phenylephrine (α-adrenergic receptor agonist, group VII) and isoproterenol (β-adrenergic receptor agonist, group IX) in a concentration range of 10-9-10-5M and their combination with 10-7M of buflomedil … Show more

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“…It has been reported by clinical and experimental studies that vasoactive treatment can alleviate the effects of lesions in peripheral nerves,[23] and Buflomedil is an effective agent for treating disorders of peripheral nerves. [48] However, its mechanism is incompletely understood. In addition, it is known that the vascular endothelial growth factor (VEGF) can protect against neuronal lesions in brain and spinal cord disorders.…”
Section: Introductionmentioning
confidence: 99%
“…It has been reported by clinical and experimental studies that vasoactive treatment can alleviate the effects of lesions in peripheral nerves,[23] and Buflomedil is an effective agent for treating disorders of peripheral nerves. [48] However, its mechanism is incompletely understood. In addition, it is known that the vascular endothelial growth factor (VEGF) can protect against neuronal lesions in brain and spinal cord disorders.…”
Section: Introductionmentioning
confidence: 99%