Effects of a Chinese Herbal Medicine, Guan-Jen-Huang (<i>Aeginetia indica</i>Linn.), on Renal Cancer Cell Growth and Metastasis

Liu, Yu-Huei; Li, Meng-Luen; Hsu, Meng-Yu; Pang, Ya-Yueh; Chen, I‐Ling; Chen, Ching-Kuei; Tang, Sai-Wen; H, Lin; Lin, Jung‐Yaw

doi:10.1155/2012/935860

Cited by 19 publications

(20 citation statements)

References 28 publications

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“…Recently, natural plant products have received considerable attention for their potential use in the treatment of malignant invasive progression, and several herbal medicines are frequently used as a supplemental therapy for many chronic diseases including cancer due to the possible beneficial effect of flavonoids (24)(25)(26)(27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Suppression of the invasive potential of highly malignant tumor cells by KIOM-C, a novel herbal medicine, via inhibition of NF-κB activation and MMP-9 expression

Kim

Yim

et al. 2013

Oncology Reports

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KIOM-C, a novel herbal formula, was recently reported to be effective for treating pigs suffering from porcine circovirus-associated disease (PCVAD). In addition, administration of KIOM-C promoted clearance of influenza virus via production of antiviral cytokines, such as TNF-α and IFN-γ. Since metastasis is the major cause of cancer-related death and the greatest challenge in cancer treatment, we investigated the effect of KIOM-C on the metastatic potential of HT1080 and B16F10 cells. We observed inhibitory properties of KIOM-C in colony-forming activity, migration and invasion. Matrix metalloproteinase-9 (MMP-9) activity in the resting and PMA-stimulated state in HT1080 cells was dose-dependently decreased by KIOM-C treatment via suppression of NF-κB activation. In addition, daily oral administration of KIOM-C at doses of 170 and 510 mg/kg, the corresponding human adult daily doses, efficiently blocked lung metastasis in C57BL/6J mice following injection of B16F10 cells in the tail veins. In particular, none of the mice administered KIOM-C during the experimental period exhibited systemic toxicity, such as body weight loss or liver and kidney dysfunction. Collectively, our results suggest that KIOM-C is a potential therapeutic formula useful as a safe herbal medicine for controlling metastatic cancer.

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Section: Discussionmentioning

confidence: 99%

Suppression of the invasive potential of highly malignant tumor cells by KIOM-C, a novel herbal medicine, via inhibition of NF-κB activation and MMP-9 expression

Kim

Yim

et al. 2013

Oncology Reports

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“…Traditional Chinese Medicinal plants are a significant source of drugs that serve as potential therapeutic compounds for the treatment of cancer (4). The rhizome of Curcuma aromatica Salisb.…”

Section: Introductionmentioning

confidence: 99%

Germacrone inhibits the proliferation of glioma cells by promoting apoptosis and inducing cell cycle arrest

Liu

Gao

Wang

et al. 2014

Molecular Medicine Reports

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Germacrone is one of the major bioactive components of the traditional Chinese Medicinal plant Curcuma aromatica Salisb. and has been shown to possess anti‑tumor properties. In the present study, the anti‑proliferative effect of germacrone on human glioma cells and the molecular mechanism underlying its cytotoxicity were investigated. Treatment of the U87 and U251 human glioma cell lines with germacrone inhibited the cell proliferation in a dose‑ and time‑dependent manner as assessed by MTT assay, while significantly lower effects were observed on normal human astrocytes. Flow cytometric analysis and DNA fragmentation revealed that germacrone promoted apoptosis of glioma cells, associated with an increased expression of p53 and bax and decreased expression of bcl‑2. Furthermore, flow cytometric cell cycle analysis revealed that germacrone induced G1 phase arrest, associated with an obvious decrease in the expression of cyclin D1 and CDK2 and an increased expression of p21. In conclusion, the present study suggested that germacrone may be a novel potent chemopreventive drug candidate for gliomas via regulating the expression of proteins associated with apoptosis and G1 cell cycle arrest.

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“…Traditional Chinese herbs serving as successful therapeutic drugs in the treatment of different types of cancers have been proved [5]. Rhizoma curcuma, a traditional Chinese herbal medicine, is commonly prescribed for treating inflammation and cancer therapy [6].…”

Section: Introductionmentioning

confidence: 99%

Germacrone exerts anti-cancer effects on gastric cancer through induction of cell cycle arrest and promotion of apoptosis

Wang

Tian

et al. 2020

BMC Complement Med Ther

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Background: Germacrone is one of the natural bioactive compounds found in Rhizoma curcuma essential oils. In this study, the potential anti-cancer effect of germacrone in gastric cancer cell line BGC823 was investigated. Methods: The cell viability and proliferative activity were assessed, and cell cycle analysis was also performed. Hoechst 33258 and Annexin V/PI double staining was used for detection of cell apoptosis. Protein profiles of cell cycle-related and apoptosis-related proteins were assessed. Results: MTT assay revealed that germacrone had marked cytotoxicity on BGC823 cells. Germacrone induced cell cycle arrest in the G2/M phase via remarkably decreased expression levels of cyclin B1, cdc 2 and cdc 25c. In addition, the treatment with germacrone induced caspase-3 activity and PARP cleavage. These findings demonstrated the effects of germacrone on inhibiting cell proliferation through induction of G2/M phase cell cycle arrest and promotion of cell apoptosis. It also indicated that germacrone functioned through modulations of cell cycle-associated protein expression and mitochondria-mediated apoptosis. Conclusion: These findings will be valuable as the molecular basis for the germacrone-mediated anti-cancer effect against gastric cancer.

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Effects of a Chinese Herbal Medicine, Guan-Jen-Huang (Aeginetia indicaLinn.), on Renal Cancer Cell Growth and Metastasis

Cited by 19 publications

References 28 publications

Suppression of the invasive potential of highly malignant tumor cells by KIOM-C, a novel herbal medicine, via inhibition of NF-κB activation and MMP-9 expression

Suppression of the invasive potential of highly malignant tumor cells by KIOM-C, a novel herbal medicine, via inhibition of NF-κB activation and MMP-9 expression

Germacrone inhibits the proliferation of glioma cells by promoting apoptosis and inducing cell cycle arrest

Germacrone exerts anti-cancer effects on gastric cancer through induction of cell cycle arrest and promotion of apoptosis

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