Effects of a combined dietary, exercise and behavioral intervention and sympathetic system on body weight maintenance after intended weight loss: Results of a randomized controlled trial

Mai, Knut; Brachs, Maria; Leupelt, Verena; Schwartzenberg, Reiner Jumpertz von; Maurer, Lukas; Grüters-Kieslich, Annette; Ernert, Andrea; Bobbert, Thomas; Krude, Heiko; Spranger, Joachim

doi:10.1016/j.metabol.2018.01.003

Cited by 28 publications

(64 citation statements)

References 32 publications

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“…The primary outcome of the RCT, weight regain after 18 months, was reported previously (3). We observed a weight loss of 24.67 6 1.47 kg/m 2 (212.6 6 3.7% of the initial BMI) during the weight loss period.…”

Section: Body Weight Changes During Weight Loss and Maintenance Periodsupporting

confidence: 69%

“…Although weight loss can be achieved by lifestyle interventions, numerous trials failed to demonstrate a long-term improvement of body weight (1,2). No or temporary delay of subsequent weight regain was achieved by a prolonged weight maintenance intervention as demonstrated by us and others (2,3). This might partly explain the lack of effect of multimodal weight loss strategies on cardiovascular events as recently shown in the Look AHEAD (Action for Health in Diabetes) trial (4).…”

Section: Lifestyle-based Weight Loss Interventions Frequently Demonstmentioning

confidence: 92%

“…In contrast, a continuous multimodal counseling focusing on caloric restriction, nutritional counseling, physical exercises, and psychological support was performed for the next 12 months in the intervention group. Further details of the intervention were reported previously (3) and are provided in the Supplementary Data.…”

Section: Twelve-month Randomized Weight Maintenance Phasementioning

confidence: 99%

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An Integrated Understanding of the Molecular Mechanisms of How Adipose Tissue Metabolism Affects Long-term Body Weight Maintenance

Mai

Wiegand

et al. 2018

Diabetes

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Section: Body Weight Changes During Weight Loss and Maintenance Periodsupporting

confidence: 69%

Section: Lifestyle-based Weight Loss Interventions Frequently Demonstmentioning

confidence: 92%

Section: Twelve-month Randomized Weight Maintenance Phasementioning

confidence: 99%

See 1 more Smart Citation

An Integrated Understanding of the Molecular Mechanisms of How Adipose Tissue Metabolism Affects Long-term Body Weight Maintenance

Mai

Wiegand

et al. 2018

Diabetes

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“…It is registered under NCT00850629 (clinicaltrials.gov). All subjects gave written informed consent (21,22). Briefly, obese subjects were anthropometrically and metabolically phenotyped (oGTT, calorimetry, bioimpedance, HE clamps) and subcutaneous WAT (scWAT)/SKM biopsy samples were taken before (T-3) and after (T0) 3 months of WR through lifestyle intervention and analyzed by RNA sequencing to discover differentially expressed genes (23).…”

Section: Clinical Studymentioning

confidence: 99%

“…Study participants were extensively characterized before (T-3) and after (T0) a 3-month WR intervention study. SKM and scWAT biopsy samples were taken and RNA sequenced (21,22). WR showed no differential regulation in SKM; however, the WR led to increased aNNMT ( Fig.…”

Section: Nnmt and Its Metabolites In A Human Wr Studymentioning

confidence: 99%

Genetic Nicotinamide N-Methyltransferase (Nnmt) Deficiency in Male Mice Improves Insulin Sensitivity in Diet-Induced Obesity but Does Not Affect Glucose Tolerance

et al. 2018

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Antisense oligonucleotide knockdown (ASO-KD) of nicotinamide N-methyltransferase (NNMT) in high-fat diet (HFD)–fed mice has been reported to reduce weight gain and plasma insulin levels and to improve glucose tolerance. Using NNMT-ASO-KD or NNMT knockout mice (NNMT−/−), we tested the hypothesis that Nnmt deletion protects against diet-induced obesity and its metabolic consequences in males and females on obesity-inducing diets. We also examined samples from a human weight reduction (WR) study for adipose NNMT (aNNMT) expression and plasma 1-methylnicotinamide (MNAM) levels. In Western diet (WD)–fed female mice, NNMT-ASO-KD reduced body weight, fat mass, and insulin level and improved glucose tolerance. Although NNMT−/− mice fed a standard diet had no obvious phenotype, NNMT−/− males fed an HFD showed strongly improved insulin sensitivity (IS). Furthermore, NNMT−/− females fed a WD showed reduced weight gain, less fat, and lower insulin levels. However, no improved glucose tolerance was observed in NNMT−/− mice. Although NNMT expression in human fat biopsy samples increased during WR, corresponding plasma MNAM levels significantly declined, suggesting that other mechanisms besides aNNMT expression modulate circulating MNAM levels during WR. In summary, upon NNMT deletion or knockdown in males and females fed different obesity-inducing diets, we observed sex- and diet-specific differences in body composition, weight, and glucose tolerance and estimates of IS.

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Therapie der Adipositas mit realistischen Therapiezielen

Wiegand

2018

Monatsschr Kinderheilkd

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Effects of a combined dietary, exercise and behavioral intervention and sympathetic system on body weight maintenance after intended weight loss: Results of a randomized controlled trial

Cited by 28 publications

References 32 publications

An Integrated Understanding of the Molecular Mechanisms of How Adipose Tissue Metabolism Affects Long-term Body Weight Maintenance

An Integrated Understanding of the Molecular Mechanisms of How Adipose Tissue Metabolism Affects Long-term Body Weight Maintenance

Genetic Nicotinamide N-Methyltransferase (Nnmt) Deficiency in Male Mice Improves Insulin Sensitivity in Diet-Induced Obesity but Does Not Affect Glucose Tolerance

Therapie der Adipositas mit realistischen Therapiezielen

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