BACKGROUND: Exercise interventions improve fitness, functional capacity, and quality of life in patients with early-stage breast cancer, but to the authors' knowledge there are few data regarding the feasibility or potential benefits of exercise in women with metastatic breast cancer. METHODS: Individuals with metastatic breast cancer were randomized 1:1 to a 16-week moderate-intensity exercise intervention or wait-list control group. Intervention goals included 150 minutes of moderate-intensity aerobic exercise per week. The baseline and 16-week evaluations included a modified Bruce Ramp treadmill test, 7-day Physical Activity Recall interview, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ C-30) questionnaire. RESULTS: A total of 101 participants were randomized (48 to the intervention group and 53 to the control group). The median age of the participants was 49 years, the median time since the diagnosis of metastatic breast cancer was 1.1 years, and approximately 42% of participants were undergoing chemotherapy at the time of enrollment. Study attrition was higher in the intervention arm (14 participants vs 8 participants; P 5 .15). Women randomized to the exercise intervention experienced a nonsignificant increase with regard to minutes of weekly exercise (
INTRODUCTIONOver the past decade, the benefits of exercise have increasingly been demonstrated for women with early breast cancer. Several observational studies have indicated that women who engage in regular exercise after a diagnosis of stage I to III breast cancer experience a lower risk of breast cancer recurrence and related mortality.1-3 In addition, >100 interventional trials have been conducted in women with early-stage breast cancer. [4][5][6] Although no trial to date has been large enough to test the impact of increased exercise on cancer-related outcomes, these studies have demonstrated that exercise is safe and provides several health benefits in patients with breast cancer both during and after adjuvant therapy.Despite these data in women with early-stage breast cancer, to our knowledge there is little information regarding the feasibility or benefits of exercise in women with advanced breast cancer. With new treatments, women often live several years after a diagnosis of metastatic breast cancer. However, during this time, many women experience significant side effects from breast cancer treatment, as well as symptoms from their disease. Fatigue, poor physical functioning, pain, and other symptoms can impair a woman's ability to complete activities of daily living in the years after the diagnosis of metastatic breast cancer, which in turn significantly compromises quality of life (QOL) and mood. Interventions are needed to help alleviate symptoms and allow women to continue to function normally in the years that they survive with advanced breast cancer.