Effects of a cosurfactant on the shear-dependent structures of systems composed of biocompatible ingredients

Phase Diagrams, Density, and Viscosity for the Pseudoternary System of {Propan-2-yl Tetradecanoate (IPM) (1) + [Tween 80 (21) + Propan-1-ol (22)] (2) + Water (3)}

“…A higher alcohol content usually leads to the microemulsion region broadening in the phase diagram and results in the formation of systems with smaller particle sizes and lower viscosities. 8 To obtain the mass ratio, mixtures of Tween 80 and propan-1-ol with the mass ratio of w 21 /w 22 = 0.1, 0.5, 1.0, 1.5, and 2.0 were tested. The cosurfactant (propan-1-ol) is used to bring the one-phase microemulsion region into an experimental window of composition.…”

“…2 Regarding to cosurfactants, short-chain alcohols are the most commonly used component in microemulsion formulations. 8 A higher alcohol content leads to a broadened microemulsion (ME) region and a diminished emulsion region in the phase diagram and results in the formation of system with smaller particle sizes and lower viscosities. The phase diagram of some microemulsions and drug delivery systems have been reported in literature, but less report on the data of equilibrium and viscosity.…”

“…The effects of composition on the state of microemulsion and on their microstructure have been the objectives of researchers. For some newly formulated drug carrier microemulsions, the phase diagram and their relative physical properties were necessarily reported. − From these properties, some new perspectives on what possible structural changes may be taking place have been given. − Among these measurements, viscosity is one simple and sensitive method, because the structural transition is reflected in the variation of viscosity with composition. The viscosity of a microemulsion is governed by two opposing effects: increasing the water content is expected to lower the viscosity, while decreasing the amount of surfactant and cosurfactant increases interfacial tension between oil and water, decreases interfacial area, increases the size of the internal domains, and therefore increases viscosity .…”

Curcumin-Encapsulated Hexagonal Liquid Crystalline Formed by Brij 97/NaDC Mixtures

“…[1] Surfactant molecules form bilayers that are regularly stacked in a lamellar phase, whereas cylinders are organized on a triangular lattice in a hexagonal phase, and a highly viscous three-dimensional structure exists in a cubic phase. [2] These systems have oil and water domains with well-defined interfaces from surfactants, which lead to the ability to solubilize a large quantity of both polar and nonpolar additives, [3] including food additives, nutraceuticals, aromatic compounds, cosmetic compounds, active ingredients, and drugs. [4] Curcumin, a hydrophobic polyphenol derived from the rhizome of the herb Curcuma longa has a wide spectrum of biological and pharmacological activities such as antioxidation, antitumor, anti-inflammatory, antivirus, and low toxicity, with promising clinical application.…”

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

“…However, if the latter does not bend light, it is isotropic (cubic arrangements); therefore, other techniques are needed for confirming this structure, 179 including small-angle X-ray scattering, small-angle neutron scattering, neutron diffraction, nuclear magnetic resonance, and cryofracture electron microscopy. 179,182,183 The LC systems significantly change the drug release profile and reduce the toxicity of drugs, improving clinical efficiency. 178 Hosmer et al in 2012, studied mesophase lamellar LCs formed with glycerides for the incorporation of the anticancer drug paclitaxel.…”