Effects of a Coupled Tumor Protein Antigen (Lewis CTPA) on the Growth of Transplanted Tumors in Inbred Mice

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Seven-week-old female C₃H/HeJ mice were given six injections of a coupled tumor protein antigen (Lewis CTPA) prior to the implantation of small pieces approximately 2 mm³ of tumor tissue into the left side of the axillary fold. Some of these mice were then given six more injections with CTPA. A third group of mice received implanted tumor tissue without prior or subsequent injections of the coupled tumor protein antigen. Careful weekly examinations for 16 weeks after the initial implantation revealed major differences in the rate of tumor growth, the relative tumor size and the mortality rates between the three groups.

Section: Discussionsupporting

confidence: 75%

Section: Methodsmentioning

confidence: 99%

“…Mice in groups A and B received two injections per week for three weeks of 0.02 ml of CTPA in alternating foot pads as described by Phillip and Daily [1971].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Phillip and Daily [1971] reported the repression of the 1 Associate Professor, Department of Basic Science, University of Detroit School of Dentistry, Detroit, Mich.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

An Immunological Study on the Effects of a Coupled Tumor Protein Antigen (Lewis CTPA) on the Growth of Transplanted Tumors in Inbred Mice

Phillip¹,

Cultrona²,

Porcelli³

1973

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Histologic Changes in Mouse Adenocarcinoma after Treatment with a Coupled Tumor Protein Antigen (Lewis CTPA)

Phillip¹,

Lewis²,

Daily³

1973

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Tumors (adenocarcinomas) excised from mice treated with coupled tumor protein antigen and from mice that were not treated (controls) were prepared according to standard histological techniques, and stained with hematoxylin and eosin. Examination of the different sections revealed that, although the general histological picture of the canalicular and invasive adenocarcinomas remained unchanged before and after treatment, cells from the nontreated tumors were uniform in shape, size and arrangement while cells from the treated tumors were heteromorphic with some cells showing a tendency to become pyknotic.

Preliminary Report on the Effects of Localized Head Irradiation on the Development of Transplanted Tumors in C<sub>3</sub>H/HeJ Mice

Phillip¹,

Maximuke²

1975

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The growth rate, as measured by increases in volume of a transplanted tumor (adenocarcinoma), was compared in mice that were irradiated locally to the head and in nonirradiated mice. 6-month-old female C₃H/HeJ mice were used, and those that were irradiated received dosages of 100 and 200 r from a Keleket 220 KVP 20 Ma X-ray machine. The dosages were delivered at 6.66 r/sec through a 0.25 cu/1.0 aluminium filter. The beam from the X-ray tube was then collimated through a series of lead shields before reaching the cranium of the mouse. 24 h after irradiation, some mice were transplanted into the left side of the axillary fold, with small pieces, approximately 2 mm₃, of tumor tissue. Careful weekly examinations for 15 weeks after the initial transplantation revealed major differences in tumor volume between irradiated and nonirradiated animals.