1987
DOI: 10.1136/thx.42.12.946
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Effects of a cyclo-oxygenase inhibitor, flurbiprofen, and an H1 histamine receptor antagonist, terfenadine, alone and in combination on allergen induced immediate bronchoconstriction in man.

Abstract: The effect of flurbiprofen, a potent cyclo-oxygenase inhibitor, on histamine and methacholine reactivity was assessed in seven atopic subjects with asthma. Flurbiprofen 150 mg daily for three days displaced the histamine-FEV, concentration-response curve to the right by 1.5 doubling doses, whereas no effect was observed on the response to methacholine. Subsequently the effects of flurbiprofen and terfenadine, a specific H, histamine receptor antagonist, on allergen induced bronchoconstriction were studied in s… Show more

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Cited by 87 publications
(50 citation statements)
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“…The PTGDR is located at chromosome 14q22.1 and is the receptor for PGD2 that may contribute to the asthma phenotype, which is characterized by pulmonary vasodilation, bronchoconstriction and recruitment of eosinophils. [7][8][9] The effects of the PTGDR on asthma were shown with a mouse study; the asthmatic symptoms of PTGDR À/À mice were improved compare with wild-type mice. 8 In addition, PGD2 15 and LTC4 16,17 are both derived from arachidonic acid.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The PTGDR is located at chromosome 14q22.1 and is the receptor for PGD2 that may contribute to the asthma phenotype, which is characterized by pulmonary vasodilation, bronchoconstriction and recruitment of eosinophils. [7][8][9] The effects of the PTGDR on asthma were shown with a mouse study; the asthmatic symptoms of PTGDR À/À mice were improved compare with wild-type mice. 8 In addition, PGD2 15 and LTC4 16,17 are both derived from arachidonic acid.…”
Section: Discussionmentioning
confidence: 99%
“…6 PGD2 may contribute to pulmonary vasodilation, bronchoconstriction, and the recruitment of eosinophils, basophils and T-lymphocytes. [7][8][9] PGD2 exerts its biological actions through the PGD2 receptor (PTGDR), which is localized to chromosome 14q22.1 and has been associated with asthma. 10 The association between asthma and PTGDR function has been recently studied with a mouse model.…”
Section: Introductionmentioning
confidence: 99%
“…This comes from the increase in plasma histamine concentrations coincident with the development of airflow obstruction [15] and the ability of HI-receptor antagonists to attenuate the airflow obstruction [16]. This suggests that HI-receptor blockade could be therapeutically effective against the clinical correlate of acute allergen exposure as seen during the pollen season.…”
Section: Discussionmentioning
confidence: 99%
“…8) Measurements of eicosanoids and their metabolites in bronchoalveolar lavage fluid (BALF) after inhaled allergen challenge of asthmatics suggest that resident mast cells, infiltrating eosinophils, basophils and macrophages are responsible for leukotrienes (LTs) and prostaglandins (PGs) in the early and late bronchoconstrictor responses. 9,10) Eicosanoids are inflammatory mediators that are biosynthesized in many cell types by cyclooxygenases (COX) and lipoxygenases (LOX). They are strongly associated with inflammatory disorders, acute as well as chronic inflammation.…”
Section: )mentioning
confidence: 99%
“…9,10) Eicosanoids are inflammatory mediators that are biosynthesized in many cell types by cyclooxygenases (COX) and lipoxygenases (LOX). They are strongly associated with inflammatory disorders, acute as well as chronic inflammation.…”
mentioning
confidence: 99%