Effects of a dopamine D1 agonist on ketamine-induced spatial working memory dysfunction in common marmosets

Nakako, Tomokazu; Murai, Takeshi; Ikejiri, Masaru; Ishiyama, Takeo; Taiji, Mutsuo; Ikeda, Kazuhito

doi:10.1016/j.bbr.2013.04.012

Cited by 35 publications

(16 citation statements)

References 34 publications

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“…Importantly, however, ketamine has been shown to affect D2-like dopamine receptors, but to have less pronounced effects on D1 receptors (Li et al, 2015). Indeed, D1 agonists have been demonstrated to antagonize the ketamine-induced effects of cognitive impairment in marmosets (Nakako et al, 2013). Hence, potential effects of ketamine anesthesia might have rather led us to underestimate the network effect of D1-based dopamine.…”

Section: Methodological Considerationsmentioning

confidence: 99%

Dopaminergic neuromodulation of high gamma stimulus phase‐locking in gerbil primary auditory cortex mediated by D1/D5‐receptors

Deliano

Brunk

Tabbal

et al. 2018

Eur J of Neuroscience

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Cortical release of the neurotransmitter dopamine has been implied in adapting cortical processing with respect to various functions including coding of stimulus salience, expectancy, error prediction, behavioral relevance and learning. Dopamine agonists have been shown to modulate recurrent cortico-thalamic feedback, and should therefore also affect synchronization and amplitude of thalamo-cortical oscillations. In this study, we have used multitaper spectral and time-frequency analysis of stimulus-evoked and spontaneous current source density patterns in primary auditory cortex of Mongolian gerbils to characterize dopaminergic neuromodulation of the oscillatory structure of current sources and sinks. We systemically applied D1/D5-receptor agonist SKF-38393 followed by competitive D1/D5-receptor antagonist SCH-23390. Our results reveal an increase in stimulus phase-locking in the high gamma-band (88-97 Hz) by SKF-38393, specifically in layers III/IV at the best frequency, which occurred at 20 ms after tone onset, and was reversed by SCH-23390. However, changes in induced oscillatory power after SKF-38393 treatment occurred stimulus-independently in the background activity in different layers than phase-locking effects and were not reversed by SCH-23390. These effects might either reflect longer-lasting changes in neural background noise, non-specific changes due to ketamine anesthesia, or an interaction of both. Without concomitant stimulus-induced power increase, increased stimulus phase-locking in layers III/IV indicates enhanced phase-resetting of neural oscillations by the stimulus after D1/D5-receptor activation. The frequency characteristics, together with the demonstrated stimulus specificity and layer specificity, suggest that changes in phase-resetting originate from dopaminergic neuromodulation of thalamo-cortical interactions. Enhanced phase-resetting might be a key step in the recruitment of cortical activity modes interpreting sensory input.

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Section: Methodological Considerationsmentioning

confidence: 99%

Dopaminergic neuromodulation of high gamma stimulus phase‐locking in gerbil primary auditory cortex mediated by D1/D5‐receptors

Deliano

Brunk

Tabbal

et al. 2018

Eur J of Neuroscience

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“…For those with hand preferences, the preferred hand often depends on their postural position (Hook and Rogers, 2008; Hashimoto et al, 2013). Marmosets have also been taught to perform memory-guided sequences of reaching movements to positions on a touch screen (Nakako et al, 2013) and to perform reaches to eccentric positions while under head and body restraint (Pohlmeyer et al, 2013). …”

Section: Comparing Marmoset and Macaque Visionmentioning

confidence: 99%

The marmoset monkey as a model for visual neuroscience

Mitchell

Leopold

2015

Neuroscience Research

215

182

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The common marmoset (Callithrix jacchus) has been valuable as a primate model in biomedical research. Interest in this species has grown recently, in part due to the successful demonstration of transgenic marmosets. Here we examine the prospects of the marmoset model for visual neuroscience research, adopting a comparative framework to place the marmoset within a broader evolutionary context. The marmoset’s small brain bears most of the organizational features of other primates, and its smooth surface offers practical advantages over the macaque for areal mapping, laminar electrode penetration, and two-photon and optical imaging. Behaviorally, marmosets are more limited at performing regimented psychophysical tasks, but do readily accept the head restraint that is necessary for accurate eye tracking and neurophysiology, and can perform simple discriminations. Their natural gaze behavior closely resembles that of other primates, with a tendency to focus on objects of social interest including faces. Their immaturity at birth and routine twinning also makes them ideal for the study of postnatal visual development. These experimental factors, together with the theoretical advantages inherent in comparing anatomy, physiology, and behavior across related species, make the marmoset an excellent model for visual neuroscience.

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“…Studies in monkeys encourage this possibility: The cognitive deficits induced by the NMDA antagonist, ketamine, were ameliorated by D1 agonist treatment (Roberts et al 2010; Nakako et al 2013). D1 agonists are currently being tested in patients with schizophrenia and those with schizotypal symptoms.…”

Section: The Neurobiological Foundations Of Schizophreniamentioning

confidence: 99%

The Neurobiology of Thought: The Groundbreaking Discoveries of Patricia Goldman-Rakic 1937-2003

Arnsten

2013

Cerebral Cortex

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Patricia S. Goldman-Rakic (1937–2003) transformed the study of the prefrontal cortex (PFC) and the neural basis of mental representation, the basic building block of abstract thought. Her pioneering research first identified the dorsolateral PFC (dlPFC) region essential for spatial working memory, and the extensive circuits of spatial cognition. She discovered the cellular basis of working memory, illuminating the dlPFC microcircuitry underlying spatially tuned, persistent firing, whereby precise information can be held “in mind”: persistent firing arises from recurrent excitation within glutamatergic pyramidal cell circuits in deep layer III, while tuning arises from GABAergic lateral inhibition. She was the first to discover that dopamine is essential for dlPFC function, particularly through D1 receptor actions. She applied a host of technical approaches, providing a new paradigm for scientific inquiry. Goldman-Rakic's work has allowed the perplexing complexities of mental illness to begun to be understood at the cellular level, including atrophy of the dlPFC microcircuits subserving mental representation. She correctly predicted that impairments in dlPFC working memory activity would contribute to thought disorder, a cardinal symptom of schizophrenia. Ten years following her death, we look back to see how she inspired an entire field, fundamentally changing our view of cognition and cognitive disorders.

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Effects of a dopamine D1 agonist on ketamine-induced spatial working memory dysfunction in common marmosets

Cited by 35 publications

References 34 publications

Dopaminergic neuromodulation of high gamma stimulus phase‐locking in gerbil primary auditory cortex mediated by D1/D5‐receptors

Dopaminergic neuromodulation of high gamma stimulus phase‐locking in gerbil primary auditory cortex mediated by D1/D5‐receptors

The marmoset monkey as a model for visual neuroscience

The Neurobiology of Thought: The Groundbreaking Discoveries of Patricia Goldman-Rakic 1937-2003

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