Effects of a Fixed Combination of Low Dose Nifedipine and Acebutolol on Essential Hypertension: Comparison with Standard Dose Acebutolol

Lejeune, Ph.; Gunselmann, W.; Hoppe, Imke; Mummel, Petra; Petersen, B.; Winkler, Elisabeth; Gfrerer, G; Schreiber, U

doi:10.3109/10641968509073608

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…This is in concordance with the results Lejeune [106] reported for a fixed combination of 10 mg nifedipine and 100 mg acebutalol. The combination was tested in a multicenter study involving 116 patients with mild to moderate hypertension.…”

Section: Hypertensionsupporting

confidence: 82%

“…A double-blind comparison of 4 weeks of treatment with nifedipine 30 mg, acebutolol 600 mg, and the combination of these two drugs with the same total daily dose showed a significant reduction of systolic and diastolic blood pressure for each of the treatment aims; only at exercise did the combination show greater blood pressure control then either of the single entities used alone. Since side effects were less common with the combination, compliance tended to be much better [107,113,133].…”

Section: Hypertensionmentioning

confidence: 99%

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Calcium channel antagonism and beta blockade in combination—A therapeutic alternative in cardiovascular disorders. A review

Lessem

Singh

1989

Cardiovasc Drug Ther

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Calcium-channel antagonists and beta-adrenergic blocking agents have become important modalities in the cardiovascular therapeutic armamentarium. These drugs are often administered as monotherapy to a wide range of cardiological patients with angina pectoris, hypertension, arrhythmias, congestive heart failure, and other diseases. Since within each class these drugs exhibit pharmacologic differences, it follows that their effectiveness varies in different disease states and that they exhibit a wide variety of side effects. In an attempt to optimize therapy, the individual drugs from these two classes can be combined; and the efficaciousness and side-effect profile of various combinations between calcium-channel antagonists and beta blockers are discussed in this review. Recommendations as to which patients may benefit from a combination and as to which patients may be harmed by the combination therapy will be made. Very few studies have compared the safety and efficacy of a single agent with the combination and with placebo in a controlled randomized fashion. To determine which therapy is superior and to determine which combination one should recommend under what circumstances, such placebo-controlled, randomized trials are a necessity, and will hopefully be performed although the complexity is enormous.

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Section: Hypertensionsupporting

confidence: 82%

Section: Hypertensionmentioning

confidence: 99%

Calcium channel antagonism and beta blockade in combination—A therapeutic alternative in cardiovascular disorders. A review

Lessem

Singh

1989

Cardiovasc Drug Ther

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Low Dose Combination Antihypertensive Therapy Additional Efficacy Without Additional Adverse Effects?

MacConnachie

Maclean

1995

Drug Safety

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Calcium Antagonists and Exercise Performance

Kindermann

1987

Sports Medicine

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Calcium antagonists lead to a relaxation of smooth vascular muscles and exert a cardiodepressive effect. They make up a heterogeneous group, with primarily substances of the nifedipine and verapamil type playing the most important role in the treatment of cardiocirculatory diseases. The principal indications include coronary heart disease and hypertension. During physical exercise, following the administration of calcium antagonists, VO2max and endurance performance are not impaired. The rate of perceived exertion does not increase to any greater extent in comparison with placebo. Nifedipine leads to an increase of noradrenaline (norepinephrine) as an expression of a reflex activation of the sympathetic system and to a slight increase in heart rate, while calcium antagonists of the verapamil type lower heart rate by 10 to 15 beats/min during physical exercise as a result of their intrinsic negative chronotropic effect. Cardiac output, in spite of the drop in heart rate, remains unchanged. Neither carbohydrate metabolism nor lipid metabolism, including lipolysis, which provide the essential energy-yielding substrates during exercise, are affected by calcium antagonists. Potassium likewise remains unchanged. The response of the hormones insulin, growth hormone and cortisol is the same with calcium antagonists both during incremental graded exercise and during prolonged exercise as with placebo. In comparison with the administration of only calcium antagonists, the combination of calcium antagonists and beta-blockers impairs physical performance. The diminishment in performance, however, is markedly less pronounced than with beta-blocker monotherapy. Unimpaired performance is crucial for physically active patients. Especially for patients performing regular physical activity who suffer from mild hypertension, calcium antagonists provide a viable therapeutic alternative to beta-blockers.

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Effects of a Fixed Combination of Low Dose Nifedipine and Acebutolol on Essential Hypertension: Comparison with Standard Dose Acebutolol

Cited by 3 publications

References 6 publications

Calcium channel antagonism and beta blockade in combination—A therapeutic alternative in cardiovascular disorders. A review

Calcium channel antagonism and beta blockade in combination—A therapeutic alternative in cardiovascular disorders. A review

Low Dose Combination Antihypertensive Therapy Additional Efficacy Without Additional Adverse Effects?

Calcium Antagonists and Exercise Performance

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