Effects of a Gastrin-Like Pentapeptide (I.C.I. 50,123) on Stomach and Pancreas

Wormsley, K. G.; Mahoney, Mark; Ng, Margaret H.L.

doi:10.1016/s0140-6736(66)90110-3

Cited by 99 publications

(15 citation statements)

References 4 publications

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“…This confirms the initial data collected by other authors [4,10,11,15] and by us [5], experimenting with this substance both in animals and humans. Such research has also confirmed that the stim ulating effect of pentagastrin on gastric secretion is less than th at of natural gastrin.…”

Section: Discussionsupporting

confidence: 91%

Intrinsic Factor and Gastric Juice Secretion Induced by Pentagastrin

Tura¹,

Monte²,

Possati³

et al. 1967

Digestion

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Section: Discussionsupporting

confidence: 91%

Intrinsic Factor and Gastric Juice Secretion Induced by Pentagastrin

Tura¹,

Monte²,

Possati³

et al. 1967

Digestion

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“…If liberation of gastrin by the antrum had occurred, it was obviously negligeable. It has been proved that gastrin has a weak excitatory effect on human exocrine pancreas [20]. In order to ascertain whether a similar phenomenon is present in dogs, the following series of experiments was undertaken.…”

mentioning

confidence: 99%

The Effects of Intragastric Ethanol Administration upon Canine Exocrine Pancreatic Secretion

Tiscornia¹,

Gullo²,

Mott³

et al. 1973

Digestion

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The effects of intragastric administration of ethanol on exocrine pancreatic secretion were assessed in 11 mongrel dogs provided with gastric and pancreatic fistulae (Thomas cannula). The gastric fistula was left open throughout the experiments to prevent gastric content from entering the duodenum. Ethanol (12% in saline) decreased the protein concentration and the output of basal pancreatic secretion. Ethanol (40% in saline) showed no effect upon pancreatic secretion stimulated by a continuous intravenous injection of GIH secretin (1.0 U/kg/h) but produced a significant increase in protein concentration and output when pancreatic secretion was stimulated by a continuous intravenous injection of Boots secretin (4.0 U/kg/h). Intragastric infusion of 80-percent (v/v) ethanol under intravenous injection of GIH secretin (1.0 U/kg/h) produced an inhibition of the flow rate and alkaline secretion and a significant increase in protein concentration and output. The latter response was suppressed by previous antrectomy.

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“…Most authors have found that subcutaneous injection of pentagas trin in a dose of 6 pg/kg body weight is sufficient for m axim al gastric secretory, but due to an increasing frequency of side effects at higher in Routine Clinical Testing of Gastric Acid Secretion 87 doses it is difficult to establish an exact dose-response curve [6,11,12,16,17]. In the present m aterial it has not been possible to show any difference in peak acid output after 6 and 9 ¡¿g/kg respectively and none of the 23 patients comprising this series has shown signs of any side effects.…”

Section: Discussionmentioning

confidence: 99%

Pentagastrin as a Stimulant in Routine Clinical Testing of Gastric Acid Secretion

Pedersen¹

1970

Digestion

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The synthetic pentapeptide, pentagastrin (ICI 50 123) has been found to be a suitable stimulant for routine examination of gastric acid secretion. The secretion was examined in 23 patients after subcutaneous injection of 6 and 9 μg, respectively, per kg. An increase of the dose to 9 μg/kg did not cause any increase in peak acid output, and a dose of 6 μg/kg has therefore been accepted as sufficient for maximal gastric stimulation. At this dosage level the results are consistent. In duplicate examinations in 23 patients, the responses had a mean deviation of 9.9%. In 15 cases peak acid output was measured after subcutaneous stimulation with histamine acid phosphate (40 μg/kg) and pentagastrin (6 μg/kg), respectively, and no difference between the two series was found. Of a total of 150 patients, 3 stated they had side effects after injection of pentagastrin. In all 3 cases these were slight and of short duration, and they did not affect the course of the study.

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Effects of a Gastrin-Like Pentapeptide (I.C.I. 50,123) on Stomach and Pancreas

Cited by 99 publications

References 4 publications

Intrinsic Factor and Gastric Juice Secretion Induced by Pentagastrin

Intrinsic Factor and Gastric Juice Secretion Induced by Pentagastrin

The Effects of Intragastric Ethanol Administration upon Canine Exocrine Pancreatic Secretion

Pentagastrin as a Stimulant in Routine Clinical Testing of Gastric Acid Secretion

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