Effects of a Gentle, Self-Administered Stimulation of Perineal Skin for Nocturia in Elderly Women: A Randomized, Placebo-Controlled, Double-Blind Crossover Trial

Iimura, Kaori; Watanabe, Nobuhiro; Masunaga, Koichi; Miyazaki, Shogo; Hotta, Harumi; Kim, Hunkyung; Hisajima, Tatsuya; Takahashi, Hitomi; Kasuya, Yutaka

doi:10.1371/journal.pone.0151726

Cited by 9 publications

(12 citation statements)

References 37 publications

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“…Based on their ndings, we had expected the contact acupuncture to be superior to the sham acupuncture ; however, this was not the case herein. Another study found that cutaneous stimulation with a roller made of the same material as the sham acupuncture device used in the present study was effective for treating overactive bladder-related nocturia in elderly women 25 . Further investigations of stimulation modalities are needed, including the degree of skin compression and the stimulation materials.…”

Section: Discussionmentioning

confidence: 51%

“…In recent years, studies have demonstrated the effects of pleasant touch on single afferent ber activities in cutaneous nerves [22][23][24][25] . Pleasant touch activates mechanoreceptors in the skin 23 , which changes autonomic function, and suppresses stress [23][24][25] .…”

Section: Discussionmentioning

confidence: 99%

“…Pleasant touch activates mechanoreceptors in the skin 23 , which changes autonomic function, and suppresses stress [23][24][25] . The afferent bers involved in regulating muscle tone consist of not only Ib and II bers of the homonymous muscle, but also bers in the cutaneous nerves 21 .…”

Section: Discussionmentioning

confidence: 99%

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Effects of Gentle Cutaneous Stimulation Using Contact and Sham Acupuncture on the H/M Ratio in Patients with Chronic Hemiparesis

Matsumoto

Mizuma

Kawate

et al. 2017

Showa Univ J Med Sci

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: This study aimed to evaluate the neurophysiological effects of gentle cutaneous stimulation by acupuncture on muscle tone in patients with chronic spastic paresis. We conducted a randomized, double-blind, crossover trial comparing the effects of contact acupuncture on the H/M ratios of soleus muscles between 8 patients with spastic paresis and 17 healthy volunteers. The study subjects were randomly assigned to two groups, and then they received gentle stimulations to their lower limb affected side using skin attachment-type contact acupuncture and sham acupuncture in different order. Fourteen acupuncture points were selected according to the Meridian-Test M-Test . The soleus muscle in both stimulated and unstimulated limbs was analyzed by electromyography following tibial electrical stimulation at the popliteal fossa, and the H/M ratios were then calculated. Paretic subjects showed a signi cant decrease in H/M ratio after both contact and sham acupunctures in the stimulated limbs, but not in the unstimulated limbs unaffected side , and this result was not affected by the order of stimulation. Healthy subjects showed a signi cant decrease in the H/M ratio after both contact and sham acupunctures in both stimulated and unstimulated limbs. The H/M ratio decrease indicates a decreased overall percentage of activated -motor neurons. Our results therefore suggest that gentle cutaneous stimulation could reduce -motor neuron excitability at rest under some conditions.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

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Effects of Gentle Cutaneous Stimulation Using Contact and Sham Acupuncture on the H/M Ratio in Patients with Chronic Hemiparesis

Matsumoto

Mizuma

Kawate

et al. 2017

Showa Univ J Med Sci

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“…Previous studies reported that noninvasive gentle stimulation applied to the perineal skin of anesthetized rats with an elastomer roller without microcones was effective for inhibiting micturition contractions, whereas stimulation applied with a polystyrene roller having a hard surface was ineffective. 12,13 In the future, more-detailed studies need to be conducted with various skin-stimulation devices to assess the effects of the presence or absence of microcones, the size and sturdiness of the device, the materials used in the device, and other factors.…”

Section: Discussionmentioning

confidence: 99%

Effects of Noninvasive Skin Stimulation with Microcones on Constipation: A Double-Blinded Controlled Study

Sawazaki

Hoshikawa

2018

Medical Acupuncture

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Objective: The use of noninvasive skin stimulation with microcones for constipation is promising. However, no double-blinded study has assessed the effects of this approach on constipation. The goal of this research was to assess the effects on constipation when using noninvasive skin stimulation with microcones. Materials and Methods: This double-blinded, controlled study included 44 subjects, each with a score of 5 points or higher on the Japanese version of the Constipation Assessment Scale (CAS-J). The subjects were randomly divided into 2 groups: (1) a stimulation group (skin-stimulation device with microcones; n = 23; group S) and (2) a placebo group (identical device without microcones; n = 21; group P). The subjects were required to attach the skin-stimulation devices to both cavum conchae with dedicated bandages every day for 2 months by themselves. Main Outcome Measures: This study assessed the severity of constipation, total mood disturbance (TMD) score, and salivary amylase activity (SAA) in each subject. Measurements were obtained before, during, and after the intervention. Results: With regard to the CAS-J score, significant differences were observed in both groups; however, no significant differences were observed between the groups. With regard to the TMD score, significant differences were observed in group S but not in group P. With regard to SAA, there were no significant differences in both groups; however, significant differences were noted after the intervention between the groups. Conclusions: Noninvasive skin stimulation with microcones could relieve constipation and improve TMD scores and SAA activity. This procedure may be used as a self-care option.

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“…In the participants with OAB, nighttime urination frequency significantly decreased from baseline during the active stimulation period compared to that during the placebo stimulation period (Fig. A) (Iimura et al, ). In contrast, micturition frequency was not affected by either stimulus in participants without OAB (Fig.…”

Section: Clinical Effects Of Gentle Skin Stimulation In Community‐dwementioning

confidence: 99%

Gentle Perineal Skin Stimulation for Control of Nocturia

Hotta

Watanabe

2019

The Anatomical Record

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One of the major causes of nocturia is overactive bladder (OAB). Somatic afferent nerve stimuli are used for treating OAB. However, clinical evidence for the efficacy of this treatment is insufficient due to the lack of appropriate control stimuli. Studies on anesthetized animals, which eliminate emotional factors and placebo effects, have demonstrated an influence of somatic stimuli on urinary bladder functions and elucidated the underlying mechanisms. In general, the effects of somatic stimuli are dependent on the modality, location, and physical characteristics of the stimulus. Recently we showed that gentle stimuli applied to the perineal skin using a soft elastomer roller inhibited micturition contractions to a greater extent than a roller with a hard surface. Studies aiming to elucidate the neural mechanisms of gentle stimulation‐induced inhibition reported that 1–10 Hz discharges of low‐threshold cutaneous mechanoreceptive Aβ, Aδ, and C fibers evoked during stimulation with an elastomer roller inhibited the micturition reflex by activating the spinal cord opioid system, thereby reducing both ascending and descending transmission between bladder and pontine micturition center. The present review will provide a brief summary of (1) the effect of somatic electrical stimulation on the micturition reflex, (2) the effect of gentle mechanical skin stimulation on the micturition reflex, (3) the afferent, efferent, and central mechanisms underlying the effects of gentle stimulation, and (4) a translational clinical study demonstrating the efficacy of gentle skin stimuli for treating nocturia in the elderly with OAB by using the two roller types inducing distinct effects on rat micturition contractions. Anat Rec, 302:1824–1836, 2019. © 2019 American Association for Anatomy

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Effects of a Gentle, Self-Administered Stimulation of Perineal Skin for Nocturia in Elderly Women: A Randomized, Placebo-Controlled, Double-Blind Crossover Trial

Cited by 9 publications

References 37 publications

Effects of Gentle Cutaneous Stimulation Using Contact and Sham Acupuncture on the H/M Ratio in Patients with Chronic Hemiparesis

Effects of Gentle Cutaneous Stimulation Using Contact and Sham Acupuncture on the H/M Ratio in Patients with Chronic Hemiparesis

Effects of Noninvasive Skin Stimulation with Microcones on Constipation: A Double-Blinded Controlled Study

Gentle Perineal Skin Stimulation for Control of Nocturia

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