Effects of a hydrated sodium calcium aluminosilicate (T-Bind) on mycotoxicosis in young broiler chickens

Abstract

Experiments were conducted to determine the ability of a hydrated sodium calcium aluminosilicate (T-Bind) sorbent to reduce the toxicity of aflatoxins (AF) or T-2 toxin in male broiler chickens from day of hatch to 21 d of age. In Experiment 1, the sorbent was added at 0.250 or 0.375% to diets containing AF at 5 or T-2 toxin at 8 mg/kg of diet. When compared with controls, AF reduced BW gain by 27% and T-2 toxin reduced BW gain by 17%. The addition of the sorbent at 0.250 or 0.375%, in the absence of added mycotoxins, did not alter the performance of the chicks. The sorbent reduced the toxic effects of 5 mg AF/kg of diet on BW gain by 43% but did not significantly diminish the toxic effects of 8 mg T-2 toxin/kg of diet. The decreased efficiency of feed utilization and the increased relative organ weights caused by AF were significantly diminished to differing degrees by the sorbent. Oral lesions caused by T-2 toxin were not affected by the sorbent. In Experiment 2, the sorbent was added at 0.80% to a diet containing 8 mg T-2 toxin/kg of diet. The sorbent did not diminish the toxic effects of T-2 toxin when added at 0.80% of the diet. These data demonstrate that this specific sorbent can provide protection against the toxicity of AF, but not T-2 toxin, in young broiler chicks.

Efficacy of Dietary Natural Zeolite andSaccharomyces cerevisiaein Counteracting Aflatoxicosis in Broiler Chicks

“…I n this experiment, the addition of 1.0 mg AFB,/kg of diet alone significantly reduced body weight g a i n (BWG) a n d feed i n t a k e ( F I ) by approximately 25 and 17%, respectively (Table l), which agree with previous reports on the performance depressing effects of AF (Huff et al, 1986;Kubena et al, 1998;Ledoux et al, 1999). These effects of AF have been attributed to reduced protein synthesis (Thaxton et al, 1974), i m p a i r e d n u t r i e n t absorption (Tyczkowski et a l .…”

“…Another possibility is that SC suppressed the severity of aflatoxicosis through chelation, by binding the AF, which is then eliminated from the intestinal tract (Cooney et al, 1980). The efficiency of feed utilization was adversely affected by feeding diet containing AFB, alone which agree with the results of several previous studies in broilers (Kubena et al, 1998) but is inconsistent with others (Huff et al, 1986; Ledoux et af., 1999). The addition of 0.5% SC to the diet containing 1.0 nig AFH,/ kg caused significant iniprovemeiit in feed efficiency wliicli was comparable with chicks fed diet without AFl3, (Control diet).…”

“…Aflatoxins (AF) cause a variety of effects in poultry including poor performance, liver pathology, inini~uiiosuppression and changes in relative organ weights (Thaxton et al., 1974;Kubena et al, 1998;Ledoiux et al., 1999).…”

“…i r i n g r e a t d e m a n d . A v a r i e t y of physical, cheiiiical a n d biological a p p r o a c h e s t o counteract the afla toxin problems have been reported in the literature on niycotoxins (Piva et al, 1993;Kubena et al, 1998;Ledoux et aZ., 1999). Unfortunately, niost of' these techniques on a large scale are costly, time consuming, ineffective or only pnrtially effective.…”

“…Unfortunately, niost of' these techniques on a large scale are costly, time consuming, ineffective or only pnrtially effective. However, sonic of' t h e r e p o r t s h a v e shown t h a t an approach to the detosif'icuation of A F adsorption from thct gastroiiitc.stinn1 t r a c t is d i e t sii pp1 enien tcd w i tli mvco t ox i 11 b i 11 t l i n g agents 39 s u c h as h y d r a t e d s o d i u m calcium aluminosilicate (HSCA), bentonite and zeolite (Piva et al, 1995;Kubena et al, 1998; Ledoux et a l . , 1999).…”