Effects of a hydroxyapatite coating on the stability of endosseous implants in rabbit tibiae

Łukaszewska-Kuska, Magdalena; Krawczyk, Piotr; Martyła, Agnieszka; Hędzelek, Wiesław; Dorocka‐Bobkowska, Barbara

doi:10.17219/dmp/103851

Cited by 18 publications

(16 citation statements)

References 21 publications

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“…30 The bone area fraction occupancy increased from 2 to 4 weeks, but without significative difference between the HAnano ® , SLActive ® to TiUnite ® . Our results corroborate with those of previous studies assessing HA-coated implants in rabbit tibia after two weeks, 59 in dogs' sockets after four weeks, 60 and in the iliac crests of goats after four weeks. 61 In all these studies, the HA biomimetic coating was able to shorten the healing period of the implants by increasing the implant-bone interaction.…”

Section: Dovepresssupporting

confidence: 92%

<p>The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone</p>

Sartoretto

Calasans-Maia

Resende

et al. 2020

IJN

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Background and Objective The success rates of dental implants in low-density bone have been reported as a challenge, especially for early or immediate loading in the maxilla posterior area. Nanoscale architecture affects the roughness, surface area, surface energy of the implant and can enhance osseointegration. This study aimed to evaluate the implant-surface topography and biomechanical, histomorphometric, and histological bone responses to a new nanostructured hydroxyapatite surface placed in the iliac crest of sheep. Methods Ten female sheep (2–4 years) received 30 implants (n=10/group): HAnano ® coated (Epikut Plus ® , S.I.N. Implant System, Sao Paulo, SP, Brazil), SLActive (BLX ® , Straumann, Basel, Switzerland), and TiUnite (NobelActive ® , Nobel Biocare, Göteborg, Sweden) surfaces. Scanning electron microscopy with energy-dispersive spectroscopy evaluated the implant surface topography, the insertion torque value, and resonance frequency analysis evaluated the primary stability, bone-implant contact, and bone-area fraction occupancy were evaluated after 14 and 28 days after implant placement. Results The surface morphology was considerably comparable between the implant groups’; however, the TiUnite ® group presented a remarkable different surface. The SLActive ® and TiUnite ® groups presented an insertion torque average of 74 (±8.9) N/cm that was similar to that of HAnano ® 72 (±8.3) N/cm (p >0.05). The resonance frequency evaluated with Osstell ® /SmartPeg ® or Penguin ® /MulTipeg ® showed similar results when assessing implants from the same group. BIC and BAFO significantly increased (p<0.05) throughout the experimental periods to all groups, but BIC and BAFO values were similar among the implants at the same time point. After 4 weeks, bone-implant contact was higher than 80% of the total length analyzed. New bone occupies around 60% of analyzed area around the implants. Conclusion HAnano ® coated surface promoted comparable osseointegration as SLActive and TiUnite in the sheep model. The three tested surfaces showed comparable osseointegration at the early stages of low-density bone repair in the sheep model.

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Section: Dovepresssupporting

confidence: 92%

<p>The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone</p>

Sartoretto

Calasans-Maia

Resende

et al. 2020

IJN

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“…By April 2020, a total of 128 studies had been gathered and subsequently assessed by the reviewers. From these, 92 studies were removed due to their being in vitro trials, duplicates, systematic reviews, or irrelevant, leaving a total of 30 studies: 27 were carried out on animals [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ] and 3 on humans [ 23 , 24 , 25 ] ( Figure 2 “Flowchart”). Table 3 and Table 4 provide a general description of the details of each study.…”

Section: Resultsmentioning

confidence: 99%

“…In animal studies, ISQ was reported by 2 studies [ 26 , 27 ], both of which showed an increase when HA and alumina bioactive surfaces were used. BIC was reported in 11 studies [ 28 , 29 , 30 , 32 , 33 , 35 , 36 , 37 , 38 , 39 , 40 , 42 , 43 , 44 , 45 , 46 , 49 , 50 , 51 ]; BIC and BA together—5 studies [ 28 , 32 , 35 , 36 , 39 ]; RTT was reported in a study using rat tibiae where machined Ti surfaces and HA coated surfaces were compared [ 48 ]; RE (microcomputed tomography) is reported in 2 studies [ 31 , 34 ], SF—in one study [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies used rabbits as animal models [ 23 , 27 , 30 , 31 , 32 , 37 , 38 , 39 , 43 , 45 , 48 , 49 ], 5—pigs [ 28 , 34 , 41 , 44 , 51 ], 4—dogs [ 29 , 46 , 47 , 52 ], 3—rats [ 33 , 35 , 42 ], 2—goat and non-human primates [ 36 , 50 ]. Sixteen modifications of the Ti surface were used, the most used bioactive surface being HA [ 27 , 29 , 36 , 44 , 46 , 49 ]. In humans, the worst results were reported by Malchiodi and colleagues who studied a bioactive surface of CaP.…”

Section: Resultsmentioning

confidence: 99%

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Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

López-Valverde

Flores-Fraile

Ramı́rez

et al. 2020

JCM

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Animal studies and the scarce clinical trials available that have been conducted suggest that bioactive surfaces on dental implants could improve the osseointegration of such implants. The purpose of this systematic review was to compare the effectiveness of osseointegration of titanium (Ti) dental implants using bioactive surfaces with that of Ti implants using conventional surfaces such as sandblasted large-grit acid-etched (SLA) or similar surfaces. Applying the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement, the MEDLINE, PubMed Central and Web of Science databases were searched for scientific articles in April 2020. The keywords used were “dental implants”, “bioactive surfaces”, “biofunctionalized surfaces”, and “osseointegration”, according to the question: “Do bioactive dental implant surfaces have greater osseointegration capacity compared with conventional implant surfaces?” Risk of bias was assessed using the Cochrane Collaboration tool. 128 studies were identified, of which only 30 met the inclusion criteria: 3 clinical trials and 27 animal studies. The average STROBE (STrengthening the Reporting of OBservational studies in Epidemiology) and ARRIVE (Animal Research: Reporting of In Vivo Experiments) scores were 15.13 ± 2.08 and 17.7±1.4, respectively. Implant stability quotient (ISQ) was reported in 3 studies; removal torque test (RTT)—in 1 study; intraoral periapical X-ray and microcomputed tomography radiological evaluation (RE)—in 4 studies; shear force (SF)—in 1 study; bone-to-implant contact (BIC)—in 12 studies; and BIC and bone area (BA) jointly—in 5 studies. All animal studies reported better bone-to-implant contact surface for bioactive surfaces as compared to control implants with a statistical significance of p < 0.05. Regarding the bioactive surfaces investigated, the best results were yielded by the one where mechanical and chemical treatment methods of the Ti surfaces were combined. Hydroxyapatite (HA) and calcium–phosphate (Ca–Ph) were the most frequently used bioactive surfaces. According to the results of this systematic review, certain bioactive surfaces have a positive effect on osseointegration, although certain coating biomolecules seem to influence early peri-implant bone formation. Further and more in-depth research in this field is required to reduce the time needed for osseointegration of dental implants.

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“…Hydroxylapatite has several medical applications in medicine and dentistry. It proved to have good osseointegration properties [16].…”

Section: Discussionmentioning

confidence: 99%

Clinical and radiological outcome after Anterior Cruciate Ligament Reconstruction using the T-Lock Osteotrans resorbable Tendon Anchor: Early Experience and Midterm Follow-up

Bangert

Jaber

Wünnemann

et al. 2020

Preprint

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Purpose Reonstruction of the Anterior cruciate ligament (ACL) using tendon grafting is an established method for restoring knee function and stability. Multiple methods are established for graft fixation. Several involve anchoring the autograft distant to the joint with hardware that remains implanted. This study reports the first early to midterm results in patients who received ACL reconstruction (ACLR) using the T-Lock Osteotrans femoral near joint fixation method with a tibial fixation using the BioactIF Osteotrans interference screw. Methods This consecutive prospective series included 20 Patients (14 Male, 6 Female) with a primary ACL rupture. All patients were treated with an ACLR using the semitendinosus autograft fixated with the T-Lock Osteotrans and were followed-up postoperatively. The following parameters were assessed: Side-to-side difference of the posterior-anterior translation measured using the KT-1000 arthrometer, Tegner activity score, Lysholm score, IKDC subjective knee evaluation form. Magnetic resonance imaging (MRI) was done to assess tunnel enlargement and integrity of the anchoring device. Results The average follow-up duration was 2.15 years (range 1–4.2 years). One patient was lost to follow-up. Two Patients suffered a traumatic ACL re-rupture 2 years postoperatively and received 2-stage revision ACLR. Difference in the posterior-anterior translation was 1.8 mm (range 0–5). The median Tegner score was 6 (range 4–10) and 9 patients (45%) returned to their preinjury level of activity. The mean IKDC subjective knee evaluation form scored 91.2 points (range 77–100). The mean Lysholm score was 86.1 points (74–96). All mentioned scores showed were significantly better compared to preoperative values. No relevant tunnel enlargement was seen on MRI. The anchoring device was evaluated to be intact in all patients. Conclusion ACLR with the aforementioned procedure leads to good clinical and radiological outcome.

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Effects of a hydroxyapatite coating on the stability of endosseous implants in rabbit tibiae

Cited by 18 publications

References 21 publications

<p>The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone</p>

<p>The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone</p>

Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review

Clinical and radiological outcome after Anterior Cruciate Ligament Reconstruction using the T-Lock Osteotrans resorbable Tendon Anchor: Early Experience and Midterm Follow-up

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