Effects of a ketogenic diet on auditory gating in DBA/2 mice: A proof-of-concept study

Tregellas, Jason R.; Smucny, Jason; Legget, Kristina T.; Stevens, Karen E.

doi:10.1016/j.schres.2015.09.022

Cited by 10 publications

(7 citation statements)

References 40 publications

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“…In schizophrenia, comorbidity with IBS [73], non-celiac gluten sensitivity [74], and the correlation between the amount of Lactobacillus and the severity of the symptomatology [75] also provide evidence of a possible connection to the MGB. Indeed, a reduction in the symptoms associated with the schizophrenia spectrum, such as delusions or disorganized behavior, has been associated with the use of a ketogenic diet [76], which could activate the auditory sensory gating deficit characterized in schizophrenia patients, as suggested in preclinical studies in DBA/2 mice [77].…”

Section: How Are Gut and Brain Diseases Related To Each Other?mentioning

confidence: 99%

Gut Microbiota and Neuroplasticity

Murciano-Brea

Garcia-Montes

Geuna

et al. 2021

Cells

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The accumulating evidence linking bacteria in the gut and neurons in the brain (the microbiota–gut–brain axis) has led to a paradigm shift in the neurosciences. Understanding the neurobiological mechanisms supporting the relevance of actions mediated by the gut microbiota for brain physiology and neuronal functioning is a key research area. In this review, we discuss the literature showing how the microbiota is emerging as a key regulator of the brain’s function and behavior, as increasing amounts of evidence on the importance of the bidirectional communication between the intestinal bacteria and the brain have accumulated. Based on recent discoveries, we suggest that the interaction between diet and the gut microbiota, which might ultimately affect the brain, represents an unprecedented stimulus for conducting new research that links food and mood. We also review the limited work in the clinical arena to date, and we propose novel approaches for deciphering the gut microbiota–brain axis and, eventually, for manipulating this relationship to boost mental wellness.

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Section: How Are Gut and Brain Diseases Related To Each Other?mentioning

confidence: 99%

Gut Microbiota and Neuroplasticity

Murciano-Brea

Garcia-Montes

Geuna

et al. 2021

Cells

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“…Additionally, it inhibits histone deacetylases and promotes metabolic regulation [35]. The KD improves neuronal function by lowering glutamate toxicity, increasing GABA inhibitory tone, and decreasing reactive oxygen species (ROS) production [49]. The mechanisms of action of the KD also include optimizing mitochondrial metabolism and neurotransmitter function, strengthening neural network stability, and improving oxidative stress and inflammation.…”

Section: Etiopathogenesis and Potential Role Of The Ketogenic Dietmentioning

confidence: 99%

The Potential Role of the Ketogenic Diet in Serious Mental Illness: Current Evidence, Safety, and Practical Advice

Rog,

Wingralek,

Nowak

et al. 2024

JCM

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The ketogenic diet (KD) is a high-fat, low-carbohydrate diet that mimics the physiological state of fasting. The potential therapeutic effects in many chronic conditions have led to the gaining popularity of the KD. The KD has been demonstrated to alleviate inflammation and oxidative stress, modulate the gut microbiota community, and improve metabolic health markers. The modification of these factors has been a potential therapeutic target in serious mental illness (SMI): bipolar disorder, major depressive disorder, and schizophrenia. The number of clinical trials assessing the effect of the KD on SMI is still limited. Preliminary research, predominantly case studies, suggests potential therapeutic effects, including weight gain reduction, improved carbohydrate and lipid metabolism, decrease in disease-related symptoms, increased energy and quality of life, and, in some cases, changes in pharmacotherapy (reduction in number or dosage of medication). However, these findings necessitate further investigation through larger-scale clinical trials. Initiation of the KD should occur in a hospital setting and with strict care of a physician and dietitian due to potential side effects of the diet and the possibility of exacerbating adverse effects of pharmacotherapy. An increasing number of ongoing studies examining the KD’s effect on mental disorders highlights its potential role in the adjunctive treatment of SMI.

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“…In a mouse model highly susceptible to seizures (DBA/2J), ketogenic diet consumption was able to successfully target sensory gating deficits (Tregellas et al, 2015), a consistently reported neurocognitive phenotype for schizophrenia spectrum populations (Earls et al, 2016). In addition, Kraeuter et al (2015) demonstrated that the administration of a ketogenic diet to NMDA receptor hypofunction mouse model of schizophrenia (MK-801) normalized model induced behaviors, led to weight loss, decreased glucose levels, and elevated β-hydroxybutyrate.…”

Section: Schizophrenia Empirically Based Diets and Nutritional Suppmentioning

confidence: 99%

Modified Mediterranean Diet for Enrichment of Short Chain Fatty Acids: Potential Adjunctive Therapeutic to Target Immune and Metabolic Dysfunction in Schizophrenia?

et al. 2017

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Growing interest in gut and digestive processes and their potential link to brain and peripheral based inflammation or biobehavioral phenotypes has led to an increasing number of basic and translational scientific reports focused on the role of gut microbiota within the context of neuropsychiatric disorders. However, the effect of dietary modification on specific gut metabolites, in association with immune, metabolic, and psychopathological functioning in schizophrenia spectrum disorders has not been well characterized. The short chain fatty acids (SCFA) acetate, butyrate, and propionate, major metabolites derived from fermentation of dietary fibers by gut microbes, interact with multiple immune and metabolic pathways. The specific pathways that SCFA are thought to target, are dysregulated in cardiovascular disease, type II diabetes, and systemic inflammation. Most notably, these disorders are consistently linked to an attenuated lifespan in schizophrenia. Although, unhealthy dietary intake patterns and increased prevalence of immune and metabolic dysfunction has been observed in people with schizophrenia; dietary interventions have not been well utilized to target immune or metabolic illness. Prior schizophrenia patient trials primarily focused on the effects of gluten free diets. Findings from these studies indicate that a diet avoiding gluten benefits a limited subset of patients, individuals with celiac disease or non-celiac gluten sensitivity. Therefore, alternative dietary and nutritional modifications such as high-fiber, Mediterranean style, diets that enrich the production of SCFA, while being associated with a minimal likelihood of adverse events, may improve immune and cardiovascular outcomes linked to premature mortality in schizophrenia. With a growing literature demonstrating that SCFA can cross the blood brain barrier and target key inflammatory and metabolic pathways, this article highlights enriching dietary intake for SCFA as a potential adjunctive therapy for people with schizophrenia.

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Effects of a ketogenic diet on auditory gating in DBA/2 mice: A proof-of-concept study

Cited by 10 publications

References 40 publications

Gut Microbiota and Neuroplasticity

Gut Microbiota and Neuroplasticity

The Potential Role of the Ketogenic Diet in Serious Mental Illness: Current Evidence, Safety, and Practical Advice

Modified Mediterranean Diet for Enrichment of Short Chain Fatty Acids: Potential Adjunctive Therapeutic to Target Immune and Metabolic Dysfunction in Schizophrenia?

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