Effects of a leukotriene receptor antagonist on exhaled leukotriene E4 and prostanoids in children with asthma

Montuschi, Paolo; Mondino, Chiara; Koch, Pierluigi; Barnes, Peter J.; Ciabattoni, Giovanni

doi:10.1016/j.jaci.2006.04.010

Cited by 81 publications

(76 citation statements)

References 31 publications

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“…With respect to cys-LTs, the discrepancy of the results between the previous breath condensate studies conducted in classic asthma patients presenting with wheezing [17,41] and our sputum study of CVA patients may have derived from possible pathophysiological differences between CVA and classic asthma. In CVA and the related condition eosinophilic bronchitis, activation of mast cells has been indicated by the increased sputum levels of the mast cell-derived tussive mediators histamine and PGD 2 [7], while this is not a feature of classic asthma [43].…”

Section: Discussioncontrasting

confidence: 91%

“…Montelukast decreases cys-LT levels in the exhaled breath of patients with classic asthma [17,41]. To our knowledge, this is the first study to investigate the detailed anti-inflammatory effect of an LTRA in CVA, and we revealed that montelukast significantly decreased sputum eosinophils as well as the cough VAS and capsaicin sensitivity but did not affect sputum levels of cys-LTs, LTB 4 , PGD 2 , PGE 2 , PGF 2 and TXB 2 .…”

Section: Discussionmentioning

confidence: 89%

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Clinical, Physiological and Anti-Inflammatory Effect of Montelukast in Patients with Cough Variant Asthma

Takemura¹,

Niimi²,

Matsumoto³

et al. 2011

Respiration

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Background: Cough variant asthma (CVA) is a phenotype of asthma presenting solely with coughing, characterized by airway hyperresponsiveness, eosinophilic inflammation and a cough response to bronchodilators. Leukotriene receptor antagonists (LTRAs) are antiasthma medications with anti-inflammatory and bronchodilatory properties. Although LTRAs exert antitussive effects in CVA, the mechanisms involved are unknown. Objectives: This study aimed to clarify the antitussive mechanisms of LTRAs in CVA patients. Methods: We prospectively observed the effect of montelukast (10 mg) daily for 4 weeks in 23 consecutive nonsmoking adults with anti-inflammatory treatment-naive CVA. We evaluated, before and after treatment, the cough visual analogue scale (VAS), pulmonary function (spirometry and impulse oscillation), methacholine airway responsiveness, cough receptor sensitivity, expressed by the concentration of capsaicin inducing 2 or more (C2) and 5 or more (C5) coughs, sputum eosinophil counts and levels of inflammatory mediators, including cysteinyl leukotrienes, leukotriene B₄, prostaglandin (PG) D₂, PGE₂, PGF₂_α and thromboxane B₂. We compared the baseline characteristics of the patients based on the symptomatic response to montelukast, defined as a decrease in the cough VAS of >25% (n = 15) or ≤25% (n = 8). Results: Montelukast significantly decreased the cough VAS (p = 0.0008), sputum eosinophil count (p = 0.013) and cough sensitivity (C2: p = 0.007; C5: p = 0.039), whereas pulmonary function, airway responsiveness and sputum mediator levels remained unchanged. Multivariate analysis showed that a better response to montelukast was associated solely with younger age (p = 0.032). Conclusion: The antitussive effect of montelukast in CVA may be attributed to the attenuation of eosinophilic inflammation rather than its bronchodilatory properties.

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Section: Discussioncontrasting

confidence: 91%

Section: Discussionmentioning

confidence: 89%

Clinical, Physiological and Anti-Inflammatory Effect of Montelukast in Patients with Cough Variant Asthma

Takemura¹,

Niimi²,

Matsumoto³

et al. 2011

Respiration

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“…On the other hand, the association between LTRA use and increased levels of both 5-LO and 15-LO pathways (LTE 4 and eoxin E 4 ) in this population, selected based on criteria other than use of LTRAs, contrasts with previous reports on LTs. 27,31,32 Because LTRAs were predominantly used in children also using regular ICSs, it might be a surrogate marker for increased asthma severity. In addition, one cannot exclude the possibility that LTRA use, previously shown to have a selective inhibitory effect on 5-LO in vitro, 33 shifts eicosanoid production in the direction of the 15-LO pathway.…”

Section: Discussionmentioning

confidence: 99%

Eoxins: A new inflammatory pathway in childhood asthma

Sachs-Olsen

Sanak

Lång

et al. 2010

Journal of Allergy and Clinical Immunology

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“…As a number of issues related to determination of particular analytes in EBC remain to be solved, most researchers recommend the ratio of inter-reactive or physiologically related analytes, leukotriene receptor antagonist:leukotriene E4, and prostanoids to be determined (16,(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Magnesium and calcium in exhaled breath condensate of children with asthma and gastroesophageal reflux disease

Dodig

Vlašić

Čepelak

et al. 2009

Clinical Laboratory Analysis

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Background: Magnesium and calcium physiologic functions are closely related. Magnesium is primarily an intracellular cation, the action of which also involves maintenance of cellular ionic balance, while influencing calcium homeostasis by blocking calcium channels. The aim of this study was to compare the concentrations of magnesium and calcium in exhaled breath condensate (EBC) of children with asthma and gastroesophageal reflux disease (GERD).Subjects and methods: EBC was collected from 66 children aged 7–14 years (23 children with acute asthma, 17 children with GERD, and 26 healthy children).Determination of magnesium and calciumconcentrations was preceded by optimization and validation for low concentrations.Results: No difference was recorded for either magnesium or calcium concentration between study groups. However, the magnesium to calcium ratio was statistically significantly lower in both GERD and asthma children as compared with control group.Conclusion: Study results showed the magnesium to calcium ratio to be a statistically significantly better indicator of certain pathologic changes than absolute concentration of either ion. J. Clin. Lab. Anal. 23:34–39, 2009. © 2009 Wiley‐Liss, Inc.

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Effects of a leukotriene receptor antagonist on exhaled leukotriene E4 and prostanoids in children with asthma

Cited by 81 publications

References 31 publications

Clinical, Physiological and Anti-Inflammatory Effect of Montelukast in Patients with Cough Variant Asthma

Clinical, Physiological and Anti-Inflammatory Effect of Montelukast in Patients with Cough Variant Asthma

Eoxins: A new inflammatory pathway in childhood asthma

Magnesium and calcium in exhaled breath condensate of children with asthma and gastroesophageal reflux disease

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