Effects of a lipase inhibitor (Orlistat) on cholecystokinin and appetite in response to a high-fat meal

Goedecke, Julia H.; Barsdorf, M; Beglinger, Christoph; Levitt, Naomi; Lambert, Estelle V.

doi:10.1038/sj.ijo.0802436

Cited by 27 publications

(12 citation statements)

References 21 publications

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“…It has been shown that fat induces satiety as long as it stays in the intestine (Beglinger and Degen, 2004;Goedecke et al, 2003). The satiety signals are released from the gastrointestinal tract triggered by the entry of food products.…”

Section: Introductionmentioning

confidence: 99%

Thylakoids suppress appetite by increasing cholecystokinin resulting in lower food intake and body weight in high‐fat fed mice

Köhnke

Lindqvist

Göransson

et al. 2009

Phytotherapy Research

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Thylakoids are membranes isolated from plant chloroplasts which have previously been shown to inhibit pancreatic lipase/colipase catalysed hydrolysis of fat in vitro and induce short-term satiety in vivo. The purpose of the present study was to examine if dietary supplementation of thylakoids could affect food intake and body weight during long-term feeding in mice. Female apolipoprotein E-deficient mice were fed a high-fat diet containing 41% of fat by energy with and without thylakoids for 100 days. Mice fed the thylakoid-enriched diet had suppressed food intake, body weight gain and body fat compared with the high-fat fed control mice. Reduced serum glucose, serum triglyceride and serum free fatty acid levels were found in the thylakoid-treated animals. The satiety hormone cholecystokinin was elevated, suggesting this hormone mediates satiety. Leptin levels were reduced, reflecting a decreased fat mass. There was no sign of desensitization in the animals treated with thylakoids. The results suggest that thylakoids are useful to suppress appetite and body weight gain when supplemented to a high-fat food during long-term feeding.

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Section: Introductionmentioning

confidence: 99%

Thylakoids suppress appetite by increasing cholecystokinin resulting in lower food intake and body weight in high‐fat fed mice

Köhnke

Lindqvist

Göransson

et al. 2009

Phytotherapy Research

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“…This phenomenon has been attributed to a prolonged lipid digestion, and as long as food is present in the intestine, satiety is promoted 4 .…”

Section: The Effect Of Thylakoid Isolates On Lipolysis When Included mentioning

confidence: 99%

“…The use of lipase inhibitors in pharmaceuticals targeting obesity is well established, Orlistat being present at the market today. A known side effect of this drug and similar lipase inhibitors is steatorrhea due to impaired lipid digestion 4 . An alternative to a pharmaceutical approach to lipase inhibition is to use food-based components to prolong lipid digestion and increase satiety, yet without causing negative side effects that reduce patient compliance.…”

Section: Plant Components As Functional Ingredients In Weight Managementmentioning

confidence: 99%

The effect of heat treatment of thylakoids on their ability to inhibit in vitro lipase/co-lipase activity

et al. 2014

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The effect of heat treatment of thylakoids on their ability to inhibit in vitro lipase/colipase activity.Östbring, Karolina; Rayner, Marilyn; Sjöholm, Ingegerd; Otterström, Jennie; Albertsson, PerÅke; Emek, Sinan Cem; Erlanson-Albertsson, Charlotte General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal AbstractThylakoids has been shown to prolong lipolysis by the inhibition of lipase/co-lipase, which makes thylakoids suitable as a functional food ingredient with satiating properties. The components of thylakoids that provide its function as a lipolysis modulator are primarily photosystems I and II, which are structurally stabilised by chlorophyll. However, chlorophyll is known to be heat sensitive yet the enzymatic inhibiting capacity after heat treatment has not been previously studied. It was hypothesised that the retained function of thylakoids after heat treatment could be correlated to the degree of degradation. Heat treatment at either 60°C, 75°C or 90°C for time interval ranging from 15 sec to 120 min induced a color shift from bright green to olive brown which was attributed to degradation. The ability of heat-treated thylakoids to inhibit lipolysis in vitro was also reduced. A correlation between chlorophyll a degradation and the enzymatic inhibiting capacity could be established which opens possibilities to use a spectrophotometric method to quantify the ability of thylakoids to inhibit lipase/co-lipase in a more rapid and cost effective way to complement the pH-stat method used today. With the degradation pattern investigated, it is then possible to design a thermal treatment process to ensure a microbiological safe appetite-reducing product and at the same time minimize the loss of functionality.

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“…There are contradictory findings between the studies that examined the effects of orlistat on satiety (5)(6)(7).…”

Section: Introductionmentioning

confidence: 94%

Efecto del tratamiento de dos días con orlistat sobre los niveles de leptina plasmática en pacientes obesas sin pérdida de peso

et al. 2016

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ResumenObjetivo: poco se conoce sobre el impacto de orlistat en el sistema leptina. Estudiamos la respuesta de la leptina plasmática y la sensación de saciedad tras dos días de tratamiento con orlistat sin dieta hipocalórica ni pérdida de peso. Material y métodos: reclutamos veinte mujeres obesas en nuestras consultas externas de medicina. Habían recibido restricción dietética y modificación del estilo de vida, pero se habían mantenido obesas con peso corporal estable durante seis meses antes de su inclusión en el estudio. Resultados: las pacientes tomaron 120 mg de orlistat 3 veces al día y mantuvieron su dieta habitual. Al inicio y dos días después del tratamiento con orlistat se repitieron el examen físico, la sensación de hambre y la analítica. No hubo diferencias significativas en el consumo de energía de la dieta, el peso corporal y la relación cintura-cadera, así como en glucosa sérica, insulina y péptido C. Solamente las concentraciones de leptina y triglicéridos en suero disminuyeron (p: 0,0001 y 0,01, respectivamente). La disminución de la concentración de leptina en suero se correlacionó positivamente con cambios en la concentración de triglicéridos (p: 0.01, r2: 0,45). La sensación de hambre aumento antes de la cena y se correlacionó negativamente con la disminución de la leptina (p: 0,0001, r2: 0,74) y triglicéridos (p: 0,02, r2: 0.59). Conclusión: estos datos sugieren que la malabsorción parcial de grasas por el tratamiento con orlistat disminuye rápidamente los niveles plasmáticos de triglicéridos y leptina. Este descenso se asoció con aumento del apetito antes de la ingesta que sigue a la comida principal del día. AbstractObjective: Little is known about the impact of orlistat on the leptin system. We studied the plasma leptin and satiety sensation response for two days of orlistat treatment without hypocaloric diet and weight loss. Material and methods: Twenty obese female subjects were recruited from our medical outpatient clinics. All of these subjects had previously received advice on dietary restriction and lifestyle modification, but remained obese with a stable body weight for at least six months before recruitment for the study. Results: Subjects were given 120 mg orlistat 3 times daily and were asked to maintain their usual diet. At baseline and two days after the treatment with orlistat, physical examination, hunger and blood analysis were repeated. There were no significant differences observed regarding energy dietary intake, body weight and waist-hip ratio, or in plasma glucose, insulin c-peptide concentrations. Only plasma leptin and triglycerides concentrations decreased (p: 0.0001 and 0.01 respectively). Decrease in plasma leptin concentration was positively correlated with changes observed in plasma triglycerides concentration (p: 0.01, r2: 0.45). Pre-dinner hunger increased and was negatively correlated with decrease in leptin (p: 0.0001, r2: 0.74) and triglycerides (p: 0.02, r2: 0.59). Conclusion: These data suggest that the partial fat malabsorption induced by the treatment wi...

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Effects of a lipase inhibitor (Orlistat) on cholecystokinin and appetite in response to a high-fat meal

Cited by 27 publications

References 21 publications

Thylakoids suppress appetite by increasing cholecystokinin resulting in lower food intake and body weight in high‐fat fed mice

Thylakoids suppress appetite by increasing cholecystokinin resulting in lower food intake and body weight in high‐fat fed mice

The effect of heat treatment of thylakoids on their ability to inhibit in vitro lipase/co-lipase activity

Efecto del tratamiento de dos días con orlistat sobre los niveles de leptina plasmática en pacientes obesas sin pérdida de peso

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