Effects of a Long-Acting Ophthalmic Formulation of Carteolol Containing Alginic Acid on the Corneal Epithelial Barrier Function and Water Retentive Effect

Tokuda, Naoto; Inoue, Jun; Yamazaki, Izumi; Ueno, Satoki; Fujisawa, S.

doi:10.1089/jop.2011.0101

Cited by 8 publications

(6 citation statements)

References 12 publications

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“…These contact lenses are made from hybrid zwitterionic 2‐hydroxyethyl methacrylate (HEMA) material. They also contain two moisturising ingredients, alginic acid which retains moisture and poloxamer, a non‐ionic surfactant, which prevents attachment of contaminants . Alginic acid, a naturally occurring anionic polysaccharide from cell walls of brown algae, can retain 200 to 300 times its weight of water and its viscosity increases in the presence of bivalent ions such as Ca 2+ .…”

mentioning

confidence: 99%

“…They also contain two moisturising ingredients, alginic acid which retains moisture and poloxamer, a non-ionic surfactant, which prevents attachment of contaminants. 15,16 Alginic acid, a naturally occurring anionic polysaccharide from cell walls of brown algae, can retain 200 to 300 times its weight of water and its viscosity increases in the presence of bivalent ions such as Ca 2+ . These properties can be exploited for retention of eyedrop ingredients on the ocular surface.…”

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confidence: 99%

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Effects of wearing a daily disposable lens on tear film: a randomised controlled trial

Chong

Yeo

Too

et al. 2016

Clinical and Experimental Optometry

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confidence: 99%

mentioning

confidence: 99%

Effects of wearing a daily disposable lens on tear film: a randomised controlled trial

Chong

Yeo

Too

et al. 2016

Clinical and Experimental Optometry

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“…Alginate also lowered the IOP due to its ability to retain water. The authors suggest further investigation over longer periods of time, as the results reported in this study were obtained in a very short installation period of 7 d. However, based on the results the authors conclude that an IOP lowering effect was observed in the patients who received the 2% Mikelan Long-Acting Ophthalmic Solution that contained alginic acid and that alginic acid acted in a complementary manner to achieve this result (Tokuda et al 2012).…”

Section: Alginate As a Drug Delivery System For The Eye Surfacementioning

confidence: 56%

“…Both studies conclude that in situ-formed composite alginate hydrogels demonstrate improved drug retention and enhanced ocular bioavailability without cytotoxicity and are viable therapeutic options to enhance drug delivery to the surface of the eye (Lin et al 2004. Tokuda et al (2012) investigated the effects of a carteolol-containing alginate-based ophthalmic formulation on corneal epithelial barrier function in an in vivo clinical trial of ten healthy participants. To assess corneal epithelial barrier function an index was created based on the fluorescein uptake measured using Kowa FL-500.…”

Section: Alginate As a Drug Delivery System For The Eye Surfacementioning

confidence: 99%

Alginate in corneal tissue engineering

Kostenko

Swioklo²,

Connon

2022

Biomed. Mater.

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Corneal blindness is the major cause of vision impairment and the fourth-largest leading cause of blindness worldwide. An allograft corneal transplant is the most routine treatment for visual loss. Further complications can occur, such as transplant rejection, astigmatism, glaucoma, uveitis, retinal detachment, corneal ulceration due to reopening of the surgical wounds, and infection. For patients with autoimmune disorders, allografting for chemical burns and infections is contraindicated because of the risk of disease transmission and further complications. Moreover, corrective eye surgery renders the corneas unsuitable for allografting, further increasing the gap between donor tissue demand and supply. Due to these challenges, other therapeutic strategies such as artificial alternatives to donor corneal tissue are being considered. This review focuses on the use of alginate as a building block of therapeutic drugs or cell delivery systems to enhance drug retention and encourage corneal regeneration. The similarity of alginate hydrogel water content to native corneal tissue makes it a promising support structure. Alginates possess desired drug carrier characteristics, such as mucoadhesiveness and penetration enhancing properties. Whilst alginates have been extensively studied for their application in tissue engineering, with many reviews being published, no reviews exist to our knowledge directly looking at alginates for corneal applications. The role of alginate in drug delivery to the surface of the eye and as a support structure (bioinspired tissue scaffold) for corneal tissue engineering is discussed. Biofabrication techniques such as gel casting, electrospinning, and bioprinting to develop tissue precursors and substitutes are compared. Finally, cell and tissue encapsulation in alginate for storage and transport to expand the scope of cell-based therapy for corneal blindness is also discussed in the light of recent applications of alginate in maintaining the function of biofabricated constructs for storage and transport.

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“…In this method, enhanced uptake of fluorescein indicates decreased corneal epithelial barrier function. Using this method, previous studies demonstrated the effects of antiglaucoma eye drops containing preservatives, such as BAK, on corneal epithelial barrier function [ 4 , 13 , 14 , 17 – 19 ]. For example, a previous study showed that fluorescein uptake was significantly increased upon exposure to either timolol with BAK or timolol without BAK (baseline and postexposure values: 37.5 and 82.0 ng/mL, resp., P < 0.001 for preserved timolol, and 35.4 versus 57.6 ng/mL, resp., P < 0.001 for unpreserved timolol), and it also showed that preserved timolol exerted a greater effect ( P = 0.028) in healthy volunteers [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Rebamipide on Ocular Surface Disorders Induced by Latanoprost and Timolol in Glaucoma Patients

Tokuda

Kitaoka

Matsuzawa

et al. 2015

Journal of Ophthalmology

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Purpose. To examine the efficacy of ophthalmic rebamipide suspensions on ocular surface disorders induced by antiglaucoma eye drops. Patients and Methods. Forty eyes of 40 patients receiving latanoprost (0.005%) and timolol (0.5%) were included in this randomized prospective study. The patients were randomly divided into two groups (n = 20): the rebamipide-treated group and control group. Changes in intraocular pressure, tear film break-up time (TBUT), and corneal epithelial barrier function were evaluated at baseline, 4 weeks, and 8 weeks after rebamipide administration. Furthermore, superficial punctate keratopathy severity was evaluated by scoring the lesion area and density. Results. There was no significant difference in intraocular pressure before and after rebamipide treatment. However, corneal epithelial barrier function improved significantly 4 and 8 weeks after rebamipide treatment. TBUT was partially, but significantly, increased (P = 0.02) 8 weeks after rebamipide treatment, whereas no significant change was observed at 4 weeks. Additionally, a significant decrease in area and density of keratopathy was observed 8 weeks after rebamipide treatment but not at 4 weeks. The control group showed no significant difference compared to baseline. Conclusions. Our data suggests that rebamipide treatment may reduce the occurrence of drug-induced ocular surface disorder.

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Effects of a Long-Acting Ophthalmic Formulation of Carteolol Containing Alginic Acid on the Corneal Epithelial Barrier Function and Water Retentive Effect

Abstract: The findings suggest that the long-acting ophthalmic formulation of carteolol containing alginic acid does not affect the corneal epithelial barrier function and that it may possess a water retentive action.

Cited by 8 publications

References 12 publications

Effects of wearing a daily disposable lens on tear film: a randomised controlled trial

Effects of wearing a daily disposable lens on tear film: a randomised controlled trial

Alginate in corneal tissue engineering

The Effect of Rebamipide on Ocular Surface Disorders Induced by Latanoprost and Timolol in Glaucoma Patients

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