Effects of a low-potency corticosteroid lotion plus a moisturizing regimen in the treatment of atopic dermatitis

Hanifin, Jon M.; Hebert, Adelaide A.; Mays, Steven R.; Paller, Amy S.; Sherertz, Elizabeth F.; Wagner, Annette; Tuley, Michael R.; Baker, Michael

doi:10.1016/s0011-393x(98)85076-5

Cited by 52 publications

(52 citation statements)

References 7 publications

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“…Indeed, there is no evidence that a more frequent application of a corticosteroid enhances its efficacy [17, 24, 25], and limited data regarding optimal frequency and quantity of application of the topical corticosteroid therapy are available [15, 17, 24, 25]. Two other studies that did not have as primary endpoint criterion the evaluation of corticosteroid consumption indirectly described a steroid-sparing effect of the emollients [26, 27]. Cork et al [26] demonstrated that specific education and counselling induced an 89% reduction of AD severity due to an 800% increase in emollient utilization without any concomitant increase in the use of topical corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

The Steroid-Sparing Effect of an Emollient Therapy in Infants with Atopic Dermatitis: A Randomized Controlled Study

2006

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Background: No study has clearly demonstrated the steroid-sparing effect of emollients in the treatment of atopic dermatitis (AD). Aim: Evaluating the effect of an emollient containing oat extracts on the amount of topical corticosteroids used in infants with moderate to severe AD. Study Design: During 6 weeks, 173 infants under 12 months old treated for inflammatory lesions by moderate- and/or high-potency topical corticosteroids randomly received the emollient or not (control group). Methods: Evaluation of corticosteroid consumption by weighing the tubes, disease severity by the Scoring Atopic Dermatitis Index (SCORAD), and infants’ and parents’ quality of life by Infant’s Dermatitis Quality of Life Index and Dermatitis Family Impact scores at D0, D21 and D42. Results: Compared to the control group, the amount of moderate- and high-potency corticosteroids used in 6 weeks decreased by 7.5% (not significant) and 42% (p < 0.05), respectively, in the emollient group. The SCORAD index, and infants’ and parents’ quality of life significantly improved (p < 0.0001) in both groups. Conclusion: The emollient treatment significantly reduced the high-potency topical corticosteroid consumption in infants with AD.

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Section: Discussionmentioning

confidence: 99%

The Steroid-Sparing Effect of an Emollient Therapy in Infants with Atopic Dermatitis: A Randomized Controlled Study

2006

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“…It was assumed that NAC could be used as a moisturizer with a similar effect like vit. E. Hydrated stratum corneum provides a flexible, intact barrier, making it highly protective, this effect is desired and it has been shown for the first time in our study that it could be gained by using NAC [28,29]. Therefore it could be concluded that progress was achieved in trial to introduce a new active ingredient for cosmetic industry.…”

Section: Discussionmentioning

confidence: 70%

Development of a w/o/w-Emulsion Containing N-Acetylcysteine for Cosmetic Use

Yener

Öke²

2009

Sci. Pharm.

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N-Acetylcysteine was known to be used as a mucolytic agent having significant antioxidant activity. It has been reported to be used to alleviate or improve various cosmetic conditions and dermatological disorders including changes or damage to skin associated with intrinsic or extrinsic aging recently. However many benefits regarding to its antioxidant effects were reported, its probable potential moisturizing effects have not been stated yet. Since N-acetylcysteine has similar effects as vitamin C, it might be assumed that it could also increase skin hydration by its antioxidant capacity. The aim of this work was to investigate the feasibility of a topical delivery system as a multiple emulsion containing N-acteylcysteine and compare the moisturizing potential of this formulation with a base multiple emulsion and vitamin E which was chosen as a popular moisturizer.

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“…They are recognized as major health issues worldwide [6], and their prevalence is rising, currently affecting 15-20% of school children and 2-10% of adults in the UK [7]. Moreover, although their symptoms tend to improve with age, most patients continue to possess features of AD and eczema throughout their adult lives [4,8]. This is because the inflammation produces severely dry, scaly, and brittle skin Resrach supported by City University London.…”

Section: Introductionmentioning

confidence: 99%

“…resulting in a skin barrier that is insufficient at protecting against environmental irritants and allergens [8]. Typically, such conditions are treated with humectants and occlusive agents that smooth the rough surface of the Stratum Corneum (SC) and normalize its moisture levels [1,8].…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of the DreamSkin® garment on relieving symptoms of eczema/dermatitis using electrical and spectroscopic methods: A case study

Qassem

Kyriacou

2014

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Citation: Qassem, M. & Kyriacou, P. A. (2014). Effectiveness of the DreamSkin (R) garment on relieving symptoms of Eczema/Dermatitis using electrical and spectroscopic methods: a case study. 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 3723-3726. doi: 10.11093723-3726. doi: 10. /EMBC.2014 This is the accepted version of the paper.This version of the publication may differ from the final published version. Abstract-Eczema, is a common skin inflammatory disorder particularly among children. The treatment of which usually consists of the application of emollients and moisturisers to maintain skin moisture and to reduce the risk of inflammation, infection and exacerbative factors. Recently, DreamSkin® Health Limited has developed a unique polymer treatment for eczema. The polymer has been applied to medical grade silk clothing as a means of delivering the therapeutic benefits to the sufferers' skin. They claim that the polymer reduces the loss of moisture caused by evaporation from damaged skin; acts as a barrier against external irritants and helps to restore the skin's natural temperature management process. The aim of this study was to assess the products effectiveness at providing symptomatic relief for a volunteer with confirmed Eczema and Atopic Dermatitis over a period of 14 days. Both skin capacitance and NIR spectra were collected during the course of the study, using the Corneometer® CM 825 and a spectrophotometer equipped with a customized reflectance probe for measurements in the Near Infrared region. The treated area showed visibly improved skin and overall results from both techniques showed a noticeable increase in skin water content after 14 days, peaking on the 7 th day. However, slight differences were observed in the magnitude of increase between the two instruments. Future work will focus on expanding this study to include more cases as well as performing statistical analysis to build upon our previous work in the area of skin hydration determinations using Near Infrared Spectroscopy. Permanent

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Effects of a low-potency corticosteroid lotion plus a moisturizing regimen in the treatment of atopic dermatitis

Cited by 52 publications

References 7 publications

The Steroid-Sparing Effect of an Emollient Therapy in Infants with Atopic Dermatitis: A Randomized Controlled Study

The Steroid-Sparing Effect of an Emollient Therapy in Infants with Atopic Dermatitis: A Randomized Controlled Study

Development of a w/o/w-Emulsion Containing N-Acetylcysteine for Cosmetic Use

Effectiveness of the DreamSkin® garment on relieving symptoms of eczema/dermatitis using electrical and spectroscopic methods: A case study

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Effects of a low-potency corticosteroid lotion plus a moisturizing regimen in the treatment of atopic dermatitis

Cited by 52 publications

References 7 publications

The Steroid-Sparing Effect of an Emollient Therapy in Infants with Atopic Dermatitis: A Randomized Controlled Study

The Steroid-Sparing Effect of an Emollient Therapy in Infants with Atopic Dermatitis: A Randomized Controlled Study

Development of a w/o/w-Emulsion Containing N-Acetylcysteine for Cosmetic Use

Effectiveness of the DreamSkin&#x00AE; garment on relieving symptoms of eczema/dermatitis using electrical and spectroscopic methods: A case study

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Effectiveness of the DreamSkin® garment on relieving symptoms of eczema/dermatitis using electrical and spectroscopic methods: A case study