Effects of a magnesium adhesive cement on bone stability and healing following a metatarsal osteotomy in horses

Waselau, Martin; Samii, Valerie F.; Weisbrode, Steven E.; Litsky, Alan S.; Bertone, Alicia L.

doi:10.2460/ajvr.68.4.370

Cited by 62 publications

(43 citation statements)

References 65 publications

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“…Similar results were presented by Waselau et al in a bone osteotomy model (15). Triangular fragments of bone were repaired with either a magnesium phosphate cement, a calcium phosphate cement, or left empty.…”

Section: Discussionsupporting

confidence: 90%

“…There are two prior studies examining the effect of magnesium-based adhesives for bone and tendon-to-bone repair (15,16). Gullota et al examined the effect of MBA on tendon-to-bone healing in a rabbit anterior cruciate ligament reconstruction model (16).…”

Section: Discussionmentioning

confidence: 99%

“…The large numbers of mast cells seen in the current study is a strong indicator of an allergic or chronic inflammatory reaction (24). This is unexpected since the composition of magnesium phosphate cement should be well tolerated in vivo (15,16). However, many implanted biomaterials trigger acute and chronic inflammatory responses that are driven by mast cells (25-28).…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies in other animal models have shown that magnesium-based adhesives have the potential to improve tendon-to-bone healing (15,16). The adhesive may improve the initial biomechanical properties of the repair and promote bone formation during healing.…”

Section: Introductionmentioning

confidence: 99%

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Use of a Magnesium-Based Bone Adhesive for Flexor Tendon-to-Bone Healing

Thomopoulos

Zampiakis

Das

et al. 2009

The Journal of Hand Surgery

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Purpose Our previous studies in a canine animal model demonstrated that the flexor tendon-to-bone insertion site has a poor capacity to heal. Magnesium based adhesives have the potential to improve tendon-to-bone healing. Therefore, we hypothesized that magnesium based bone adhesive (MBA) will improve the tendon-to-bone biomechanical properties initially and in the early period after repair. Methods Flexor digitorum profundus tendons were injured and repaired into bone tunnels in the distal phalanges of dogs. The bone tunnels were either filled with MBA prior to completing the repair or left empty (CTL). Histologic appearance, tensile properties, range of motion, and bone density were examined at time zero and 21 days after the repair. Results There was no histologic evidence of acute inflammation. There appeared to be more mast cells in the MBA group than in the CTL group. Chronic inflammatory infiltrate and fibrosis was slightly higher in the MBA group compared to the CTL group. Tensile properties at time zero were significantly higher in the MBA group compared to the CTL group. However, tensile properties were significantly lower in the MBA group compared to the CTL group at 21 days. Range of motion and bone density were significantly lower in the MBA and CTL groups compared to normal (i.e., uninjured) at 21 days; no differences were seen when comparing MBA to CTL. Conclusions We found that the initial biomechanical properties of flexor tendon-to-bone repairs can be improved with MBA. However, MBA use in vivo led to a decrease in the biomechanical properties of the repair. There was no effect of MBA on bone density or range of motion in the early period after repair. Our histologic analysis suggests that the poor healing in the MBA group may have been due to an allergic response or to increased chronic inflammation due to the foreign material.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Use of a Magnesium-Based Bone Adhesive for Flexor Tendon-to-Bone Healing

Thomopoulos

Zampiakis

Das

et al. 2009

The Journal of Hand Surgery

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“…Using the dorsolateral-plantaromedial-oblique views, external callus area at the Mt4 osteotomy site was estimated by multiplying the length and width of the callus measured on the plantarolateral surface of the Mt4 (mm 2 ). 5,19 Using the dorsomedial-plantarolateral-oblique views, mineralization area at the Mt2 ostectomy site was estimated by multiplying the length and width of the mineralized tissue within the gap of Mt2 (mm 2 ).…”

Section: Radiographic Evaluationmentioning

confidence: 99%

Osteogenic gene regulation and relative acceleration of healing by adenoviral‐mediated transfer of human BMP‐2 or ‐6 in equine osteotomy and ostectomy models

Ishihara

Shields²,

Litsky

et al. 2008

Journal Orthopaedic Research

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This study evaluated healing of equine metatarsal osteotomies and ostectomies in response to percutaneous injection of adenoviral (Ad) bone morphogenetic protein (BMP)-2, Ad-BMP-6, or beta-galactosidase protein vector control (Ad-LacZ) administered 14 days after surgery. Radiographic and quantitative computed tomographic assessment of bone formation indicated greater and earlier mineralized callus in both the osteotomies and ostectomies of the metatarsi injected with Ad-BMP-2 or Ad-BMP-6. Peak torque to failure and torsional stiffness were greater in osteotomies treated with Ad-BMP-2 than Ad-BMP-6, and both Ad-BMP-2-and Ad-BMP-6-treated osteotomies were greater than Ad-LacZ or untreated osteotomies. Gene expression of ostectomy mineralized callus 8 weeks after surgery indicated upregulation of genes related to osteogenesis compared to intact metatarsal bone. Expression of transforming growth factor beta-1, cathepsin H, and gelsolin-like capping protein were greater in Ad-BMP-2-and Ad-BMP-6-treated callus compared to Ad-LacZtreated or untreated callus. Evidence of tissue biodistribution of adenovirus in distant organs was not identified by quantitative PCR, despite increased serum antiadenoviral vector antibody. This study demonstrated a greater relative potency of Ad-BMP-2 over Ad-BMP-6 in accelerating osteotomy healing when administered in this regimen, although both genes were effective at increasing bone at both osteotomy and ostectomy sites. ß

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A Bone Glue with Sustained Adhesion under Wet Conditions

Wistlich

Rücker

Schamel

et al. 2016

Adv Healthcare Materials

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Bone glues often suffer from low adhesion to bone under wet conditions. This study aims to improve wet adhesiveness of a bone glue based on a photocurable poly(ethylene glycol) dimethacrylate matrix through in situ interpenetrating network formation by addition of six-armed isocyanate functional star-shaped prepolymers (NCO-sP(EO-stat-PO)). Biodegradable ceramic fillers are added to adjust the paste workability. The 3-point bending strength of the bone glues is in the range of 3.5-5.5 MPa and not significantly affected by the addition of NCO-sP(EO-stat-PO). Storage in phosphate buffered saline (PBS) decreases the bending strength of all formulations to approximately 1 MPa but the adhesion to cortical bone increases from 0.15-0.2 to 0.3-0.5 MPa after adding 20-40 wt% NCO-sP(EO-stat-PO) to the matrix. Bone glues without the NCO-sP(EO-stat-PO) additive lose their adhesiveness to bone after aging in PBS for 7 days, whereas modified glues maintain a shear strength of 0.18-0.25 MPa demonstrating the efficacy of the approach. Scanning electron microscopy and energy-dispersive X-ray spectroscopy investigations of the fracture surfaces prove a high amount of residual adhesive on the bone surface indicating that adhesion to the bone under wet conditions is stronger than cohesion.

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Effects of a magnesium adhesive cement on bone stability and healing following a metatarsal osteotomy in horses

Abstract: Both bone cements were biocompatible in horses, and Mg-cement may assist fracture repair by osteogenesis and fragment stabilization. Further studies are warranted on other applications and to define degradation characteristics.

Cited by 62 publications

References 65 publications

Use of a Magnesium-Based Bone Adhesive for Flexor Tendon-to-Bone Healing

Use of a Magnesium-Based Bone Adhesive for Flexor Tendon-to-Bone Healing

Osteogenic gene regulation and relative acceleration of healing by adenoviral‐mediated transfer of human BMP‐2 or ‐6 in equine osteotomy and ostectomy models

A Bone Glue with Sustained Adhesion under Wet Conditions

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