Effects of a massage-like essential oil application procedure using Copaiba and Deep Blue oils in individuals with hand arthritis

Bahr, Tyler; Allred, Kathryn; Martinez, Devin; Rodriguez, Damian; Winterton, Paul

doi:10.1016/j.ctcp.2018.10.004

Cited by 43 publications

(21 citation statements)

References 19 publications

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“…Contudo, o interesse das microemulsões partem de vantagens potenciais em relação as formulações tradicionais, tendo como benefícios a maior capacidade de absorção e biodisponibilidade dos princípios ativos, com liberação controlada da droga, e redução de efeitos indesejados (ZHANG et al, 2016;LIMA et al, 2018;BAHR et al,2018). v.…”

Section: Benefícios Dos óLeos Essenciais Para Saúdeunclassified

Princípios E Generalidades Sobre a Ação Dos Fármacos

Gois¹,

Nunes²

2022

Pesquisas E Abordagens Educativas Em Ciências Da Saúde

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Pesquisas e abordagens educativas em ciências da saúde -Volume II está licenciado sob CC BY 4.0.Esta licença exige que as reutilizações deem crédito ao criador. Ele permite que os reutilizadores distribuam, remixem, adaptem e construam o material em qualquer meio ou formato, mesmo para fins comerciais. O conteúdo da obra e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, não representando a posição oficial da Editora Amplla. É permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores. Todos os direitos para esta edição foram cedidos à Editora Amplla.

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Section: Benefícios Dos óLeos Essenciais Para Saúdeunclassified

Princípios E Generalidades Sobre a Ação Dos Fármacos

Gois¹,

Nunes²

2022

Pesquisas E Abordagens Educativas Em Ciências Da Saúde

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“…BCP was administered to diabetes patients with diabetesrelated complications; painful distal symmetric polyneuropathy was found to relieve polyneuropathy with an increased amplitude and a reduction of pain, with good tolerance and no adverse effects (Semprini et al, 2018). Recently, in a placebo-controlled clinical study, patients with hand arthritis applied BCPcontaining copaiba oil topically and BCP was found to be safe, well tolerated, and beneficial in reducing pain and inflammation (Bahr et al, 2018).…”

Section: Clinical Efficacy and Safety Of Bcpmentioning

confidence: 99%

β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19

et al. 2021

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Coronavirus disease (COVID-19), caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing pandemic and presents a public health emergency. It has affected millions of people and continues to affect more, despite tremendous social preventive measures. Identifying candidate drugs for the prevention and treatment of COVID-19 is crucial. The pathogenesis and the complications with advanced infection mainly involve an immune-inflammatory cascade. Therefore, therapeutic strategy relies on suppressing infectivity and inflammation, along with immune modulation. One of the most promising therapeutic targets for the modulation of immune-inflammatory responses is the endocannabinoid system, particularly the activation of cannabinoid type 2 receptors (CB2R), a G-protein coupled receptor which mediates the anti-inflammatory properties by modulating numerous signaling pathways. To pharmacologically activate the CB2 receptors, a naturally occurring cannabinoid ligand, beta-caryophyllene (BCP), received attention due to its potent anti-inflammatory, antiviral, and immunomodulatory properties. BCP is recognized as a full selective functional agonist on CB2 receptors and produces therapeutic effects by activating CB2 and the nuclear receptors, peroxisome proliferator-activated receptors (PPARs). BCP is regarded as the first dietary cannabinoid with abundant presence across cannabis and non-cannabis plants, including spices and other edible plants. BCP showed tissue protective properties and favorably modulates numerous signaling pathways and inhibits inflammatory mediators, including cytokines, chemokines, adhesion molecules, prostanoids, and eicosanoids. Based on its pharmacological properties, molecular mechanisms, and the therapeutic potential of BCP as an immunomodulator, anti-inflammatory, organ-protective, and antiviral, we hypothesize that BCP could be a promising therapeutic and/or preventive candidate to target the triad of infection, immunity, and inflammation in COVID-19. In line with numerous studies that proposed the potential of cannabinoids in COVID-19, BCP may be a novel candidate compound for pharmaceutical and nutraceutical development due to its unique functional receptor selectivity, wide availability and accessibility, dietary bioavailability, nonpsychoactivity, and negligible toxicity along with druggable properties, including favorable pharmacokinetic and physicochemical properties. Based on reasonable pharmacological mechanisms and therapeutic properties, we speculate that BCP has potential to be investigated against COVID-19 and will inspire further preclinical and clinical studies.

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“…Copaiba essential oil is a concentrated liquid obtained by steam distillation of the oleoresin of the copaiba tree. Copaiba essential oil is highly versatile and broadly utilized across multiple industries, including the cosmetic, food and wellness industries [1,2]. Currently, copaiba essential oil is being used extensively for its fragrant and emollient properties in various cosmetic products.…”

Section: Introductionmentioning

confidence: 99%

Fast-Acting and Receptor-Mediated Regulation of Neuronal Signaling Pathways by Copaiba Essential Oil

Urasaki

Beaumont²,

Workman³

et al. 2020

IJMS

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This study examined the biological activities of copaiba essential oil via measurement of its effects on signaling pathways in the SH-SY5Y neuronal cell line. Nanofluidic proteomic technologies were deployed to measure the phosphorylation of biomarker proteins within the signaling cascades. Interestingly, copaiba essential oil upregulated the pI3K/Akt/mTOR, MAPK, and JAK/STAT signaling pathways in neuronal cells. The effects of copaiba essential oil peaked at 30 min post-treatment, with a half-maximal effective concentration (EC50) of approximately 80 ng/mL. Treatment with cannabinoid receptor 2 (CB2) agonist AM1241 or the inverse agonist BML190 abrogated the regulatory effects of copaiba essential oil on the pI3K/Akt/mTOR signaling pathway. Surprisingly, copaiba essential oil also activated the apoptosis signaling pathway and reduced the viability of SH-SY5Y cells with an EC50 of approximately 400 ng/mL. Furthermore, β-caryophyllene, a principal constituent of copaiba essential oil, downregulated the pI3K/Akt/mTOR signaling pathway. Taken together, the findings indicated that copaiba essential oil upregulated signaling pathways associated with cell metabolism, growth, immunity, and apoptosis. The biological activities of copaiba essential oil were determined to be fast acting, CB2 mediated, and dependent on multiple chemical constituents of the oil. Nanofluidic proteomics provided a powerful means to assess the biological activities of copaiba essential oil.

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Effects of a massage-like essential oil application procedure using Copaiba and Deep Blue oils in individuals with hand arthritis

Cited by 43 publications

References 19 publications

Princípios E Generalidades Sobre a Ação Dos Fármacos

Princípios E Generalidades Sobre a Ação Dos Fármacos

β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19

Fast-Acting and Receptor-Mediated Regulation of Neuronal Signaling Pathways by Copaiba Essential Oil

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