Effects of a microbubble ultrasound contrast agent on high-intensity focused ultrasound for uterine fibroids: a randomised controlled trial

Abstract

SonoVue could be safely used to enhance the ablation effects of HIFU treatment of uterine fibroids.

Efficacy and safety of high-intensity focused ultrasound ablation for hepatocellular carcinoma by changing the acoustic environment: microbubble contrast agent (SonoVue) and transcatheter arterial chemoembolization

“…On the procedure of HIFU, we found that the energy and time required for the first MGSCs in the SonoVue group were significantly smaller than those in the TACE group. It might be related to the enhancement of cavitation and thermal effects on the microbubbles [14,21,31]. However, there were no significant differences in the average sonication power, total energy, HIFU sonication time, and EEF in the two groups.…”

“…In addition, microbubbles enhance the mechanical effects of HIFU, destroy the histiocytic ultrastructure of cells, and cause more severe damage to the target region [13]. At present, multiple clinical trials for benign lesions (uterine fibroids and adenomyosis) have shown that SonoVue can enhance the ablation effect, reduce EEF, and improve the efficacy, reflecting that it is a safe and effective treatment method [14,[28][29][30][31]. A 70-year-old male patient with HCC in the TACE group.…”

“…The length (D1), thickness (D2) and width (D3) of tumor-like lesion were preoperatively measured on MRI images; correspondingly, the length (d1), thickness (d2) and width (d3) of the non-perfused region were postoperatively measured. The tumor volume was calculated by V1 ¼ (1/6)  p  D1  D2  D3 [13,14], the volume of non-perfused volume (NPV) was calculated by V2 ¼ (1/6)  p  d1  d2  d3, and the ablation rate (%) ¼ V2/ V1  100%. The blood supply of lesions was evaluated by preoperative MRI images, and the proposed method is detailed in the following.…”

Contrast-Enhanced Ultrasound for Monitoring Non-surgical Treatments of Uterine Fibroids: A Systematic Review

“…Patients were randomly divided into four groups with SonoVue used in Groups A and B and saline used in Groups C and D as controls. Results showed that NPV ratio was significantly higher in the SonoVue group than that in the saline group (p = 0.006), and starting HIFUA earlier after SonoVue injection (6 min in groups A &C vs. 10 min in groups B&D) was safe and could significantly shorten the treatment time (p = 0.013) and sonication time (p = 0.04) (Chen et al 2018).…”

Comparison of outcomes of hysteroscopic myomectomy of type 2 submucous fibroids greater than 4 cm in diameter via pretreatment with HIFU or GnRH-a

“…The patients' vital signs such as heart rate, blood pressure, respiration, oxygen saturation were monitored during the procedure. The following formula: V ¼ (1/6) Â p ÂD1 Â D2 Â D3 was used to calculated the volume of the fibroids, the nonperfused volume, and the volume of the uterus [16].…”