Effects of a mindfulness‐based intervention on cancer‐related cognitive impairment: Results of a randomized controlled functional magnetic resonance imaging pilot study

Gucht, Katleen Van der; Ahmadoun, Soumaya; Melis, Michelle; Cloe, Ellen de; Sleurs, Charlotte; Radwan, Ahmed; Blommaert, Jeroen; Takano, Keisuke; Vandenbulcke, Mathieu; Wildiers, Hans; Neven, Patrick; Kuppens, Peter; Raes, Filip; Smeets, Ann; Sunaert, Stefan; Deprez, Sabine

doi:10.1002/cncr.33074

Cited by 42 publications

(66 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All of these studies had used functional MRI as the neuroimaging method. Of these, 40% (4/10) were cross-sectional in design (Zick et al, 2014 ; Churchill et al, 2015 ; Hampson et al, 2015 ; Menning et al, 2015 ), 40% (4/10) were prospective (McDonald et al, 2012 ; López Zunini et al, 2013 ; Askren et al, 2014 ; Menning et al, 2017 ), and 20% (2/10) were randomized clinical trials (Harris et al, 2017 ; Van der Gucht et al, 2020 ). The two randomized controlled trials compared the effect of interventions: relaxing vs. stimulating acupressure (Harris et al, 2017 ), and mindfulness vs. waitlist control condition in fatigued BC survivors (Van der Gucht et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

“…In 50% (5/10) of studies, neuroimaging was performed before and after completion of chemotherapy (McDonald et al, 2012 ; López Zunini et al, 2013 ; Askren et al, 2014 ; Menning et al, 2015 , 2017 ). In 40% (4/10) studies, neuroimaging was performed in fatigued BC survivors (Zick et al, 2014 ; Hampson et al, 2015 ; Harris et al, 2017 ; Van der Gucht et al, 2020 ), ( Table 2 ). The comparison group consisted of no-cancer controls in 60% of the studies (McDonald et al, 2012 ; López Zunini et al, 2013 ; Askren et al, 2014 ; Churchill et al, 2015 ; Menning et al, 2015 , 2017 ), 20% studies compared fatigued BC survivors to non-fatigued BC survivors (Zick et al, 2014 ; Hampson et al, 2015 ) and 20% were interventional studies in fatigued BC survivors ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…In one interventional study, fatigued BC survivors undergoing relaxing acupressure were compared to fatigued BC survivors undergoing stimulating acupressure (Harris et al, 2017 ). In the other interventional study, BC survivors undergoing mindfulness meditation were compared to BC survivors on a control waitlist (Van der Gucht et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

“…In the two interventional studies investigating the effect of acupressure and mindfulness on CRF, fatigue scores significantly improved with treatment (Harris et al, 2017;Van der Gucht et al, 2020). In all studies, the relationship of CRF with observed brain changes was reported after controlling for the confounding effect of at least one psychological covariate (such as anxiety, worry, or depression).…”

Section: Clinical Outcomementioning

confidence: 99%

See 3 more Smart Citations

Neural Mechanisms Underlying Breast Cancer Related Fatigue: A Systematic Review of Neuroimaging Studies

et al. 2021

View full text Add to dashboard Cite

Introduction: Fatigue and cognitive dysfunction commonly co-occur in breast cancer patients and survivors. However, the underlying neural mechanism is not clear. We performed a systematic review of studies that used neuroimaging methods to investigate structural and functional changes in the brain associated with fatigue in breast cancer patients and survivors.Methods: We searched PubMed, Scopus, EmBase, and Cochrane CENTRAL from January 2009 to May 2021 for studies that reported brain neuroimaging findings in relationship to fatigue in breast cancer patients or survivors. Neuroimaging methods included magnetic resonance imaging (MRI), positron emission tomography (PET), and electroencephalogram (EEG). We summarized structural and functional neuroimaging changes associated with fatigue.Results: Of the 176 articles retrieved, ten MRI studies reported neuroimaging findings in relationship to fatigue. Together these studies compared 385 breast cancer patients or survivors to 205 controls. Fatigue was associated with reduced white matter integrity and increased glutamate in the insula but changes in gray matter volume were not associated with fatigue score. Nine of the ten studies found significant associations between fatigue and functional changes in the frontoparietal cortex. In response to memory and planning tasks, fatigue was associated with increased activations in several regions of the frontoparietal cortex, however, overall performance on tasks was not reduced. Fatigue was also associated with extensive changes in the connectivity of brain networks that filter endogenous signals (salience network), internal attention (default mode network), and external attention (dorsal attention network). Subcortical regions associated with fatigue included insula (interoception), superior colliculus (sleep regulation), and thalamus (alertness). Functional brain changes before initiation of chemotherapy were a better predictor of post-treatment fatigue than chemotherapy itself.Conclusions: Fatigue in breast cancer is associated with widespread functional changes of brain regions and networks that affect executive function including memory, planning, internal and external attention. Observed changes likely represent a compensatory mechanism through which breast cancer patients and survivors try to maintain adequate executive function. Breast cancer patients scheduled to undergo chemotherapy are at high risk for developing fatigue even before the start of treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Clinical Outcomementioning

confidence: 99%

See 2 more Smart Citations

Neural Mechanisms Underlying Breast Cancer Related Fatigue: A Systematic Review of Neuroimaging Studies

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Regarding interactions with other networks, correlations between emotion and attention to cognition scale performance have been clinically discovered, and self-reference processing may be partially involved (Berkovich-Ohana et al, 2012;Amft et al, 2015;Catalino et al, 2020;Tomova et al, 2020;Van der Gucht et al, 2020). The dorsal attention network (DAN) and salience network (SN), which function across both high-level cognitive and attention networks (Arkin et al, 2020;Shi et al, 2020), participate in the regulation of networks between state switching of the brain (Gao and Lin, 2012;He et al, 2014;Chand et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Self-reference Network-Related Interactions During the Process of Cognitive Impairment in the Early Stages of Alzheimer’s Disease

Wei

Chen

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

Background: Normal establishment of cognition occurs after forming a sensation to stimuli from internal or external cues, in which self-reference processing may be partially involved. However, self-reference processing has been less studied in the Alzheimer’s disease (AD) field within the self-reference network (SRN) and has instead been investigated within the default-mode network (DMN). Differences between these networks have been proven in the last decade, while ultra-early diagnoses have increased. Therefore, investigation of the altered pattern of SRN is significantly important, especially in the early stages of AD.Methods: A total of 65 individuals, including 43 with mild cognitive impairment (MCI) and 22 cognitively normal individuals, participated in this study. The SRN, dorsal attention network (DAN), and salience network (SN) were constructed with resting-state functional magnetic resonance imaging (fMRI), and voxel-based analysis of variance (ANOVA) was used to explore significant regions of network interactions. Finally, the correlation between the network interactions and clinical characteristics was analyzed.Results: We discovered four interactions among the three networks, with the SRN showing different distributions in the left and right hemispheres from the DAN and SN and modulated interactions between them. Group differences in the interactions that were impaired in MCI patients indicated that the degree of damage was most severe in the SRN, least severe in the SN, and intermediate in the DAN. The two SRN-related interactions showed positive effects on the executive and memory performances of MCI patients with no overlap with the clinical assessments performed in this study.Conclusion: This study is the first and primary evidence of SRN interactions related to MCI patients’ functional performance. The influence of the SRN in the ultra-early stages of AD is nonnegligible. There are still many unknowns regarding the contribution of the SRN in AD progression, and we strongly recommend future research in this area.

show abstract

The impact of mindfulness on cancer‐related cognitive impairment in breast cancer survivors with cognitive complaints

Melis

Schroyen

Leenaerts

et al. 2023

Cancer

Self Cite

View full text Add to dashboard Cite

Background Interventions that target cancer‐related cognitive impairment (CRCI) to improve the quality of life of cancer survivors are needed. In this study, the potential of a mindfulness‐based intervention to reduce CRCI in breast cancer survivors, compared with physical training and a wait list control group, was investigated. Methods Breast cancer survivors with cognitive complaints (N = 117) were randomly allocated to a mindfulness (n = 43), physical training (n = 36), or wait list control condition (n = 38). Participants completed neuropsychological tests and questionnaires before the intervention, immediately after, and 3 months after intervention. The primary outcome measure was the change in cognitive complaints over time. Secondary outcomes were objective cognitive impairment and psychological well‐being. All outcomes were compared between groups over time using linear mixed models, including participants with missing values. Results Of the 117 included participants, 96 completed the three assessments. Participants in the three groups reported decreased cognitive complaints after intervention, without group differences. There were no between‐group differences in objective cognitive impairment after intervention compared with baseline. Compared with the wait list control group, participants reported increased mindfulness skills and reduced emotional distress after mindfulness and reduced emotional distress and fatigue after physical training. Conclusion Contrary to the hypothesis, all groups reported an improvement in cognitive complaints over time. It is suggested that priming and acknowledgment of CRCI might alter the experience of cognitive impairment. Additionally, both mindfulness‐based intervention and physical training can improve psychological well‐being of breast cancer survivors with cognitive complaints.

show abstract

Effects of a mindfulness‐based intervention on cancer‐related cognitive impairment: Results of a randomized controlled functional magnetic resonance imaging pilot study

Cited by 42 publications

References 62 publications

Neural Mechanisms Underlying Breast Cancer Related Fatigue: A Systematic Review of Neuroimaging Studies

Neural Mechanisms Underlying Breast Cancer Related Fatigue: A Systematic Review of Neuroimaging Studies

Self-reference Network-Related Interactions During the Process of Cognitive Impairment in the Early Stages of Alzheimer’s Disease

The impact of mindfulness on cancer‐related cognitive impairment in breast cancer survivors with cognitive complaints

Contact Info

Product

Resources

About