Effects of a mineralization-promoting peptide on the physical and chemical properties of mineral trioxide aggregate

Öztürk, Zeynep; Bal, Cenkhan; Gungormus, Mustafa; Aksoy, Merve

doi:10.1016/j.jmbbm.2022.105570

Cited by 1 publication

(1 citation statement)

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“…As an alternative to CH, a Portland-derived mineral trioxide aggregate (MTA) cement, was introduced, which has become popular because of its excellent biocompatibility and favourable physio-chemical properties with greater clinical success (Alnour et al, 2023;Davaie et al, 2021;Ricucci et al, 2019;Suhag et al, 2019). However, MTA has several limitations, such as prolonged setting time and difficulties during handling, often leading to tooth discolouration and high costs (Ozturk et al, 2023;Schwendicke et al, 2015). Nevertheless, extensive investigation has been conducted to modify MTA to overcome its main drawbacks (Kharouf et al, 2021;Shin et al, 2021;Toida et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Biological evaluation of novel phosphorylated pullulan‐based calcium hydroxide formulations as direct pulp capping materials: An in vivo study on a rat model

Islam,

Liu

et al. 2024

Int Endodontic J

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AimCalcium hydroxide (CH) has been considered as a direct pulp capping materials (DPC) for the last decades despite having some limitations. Phosphorylate pullulan (PPL) incorporated with CH (CHPPL) is a novel biomaterial that was introduced as a promising DPC material. Thus, the aim of the study was to evaluate the inflammatory response and mineralized tissue formation (MTF) ability of PPL‐based CH formulations on rat molars after DPC.MethodologyThis study consisted of six groups: CH with 1% PPL (CHPPL‐1); 3% PPL (CHPPL‐3); 5% PPL (CHPPL‐5); Dycal and NEX MTA Cement (N‐MTA) as the positive control, and no capping materials (NC). One hundred twenty maxillary first molar cavities were prepared on Wistar rats. After capping, all the cavities were restored with 4‐META/MMA‐TBB resin and pulpal responses were evaluated at days 1, 7, and 28. Kruskal–Wallis followed by Mann–Whitney U‐test was performed with a significance level of 0.05. Immunohistochemical expression of IL‐6, Nestin, and DMP‐1 was observed.ResultsAt day 1, CHPPL‐1, N‐MTA, and Dycal exhibited no to mild inflammation, whilst CHPPL‐3, CHPPL‐5, and NC showed mild to moderate inflammation, and the results were significantly different (p < .05). At day 7, mild to moderate inflammation was observed in CHPPL‐1, N‐MTA, and Dycal, whereas CHPPL‐3, CHPPL‐5, and NC exhibited moderate to severe inflammation. Significant differences were observed between CHPPL‐1 and N‐MTA with NC (p < .05), CHPPL‐1 and CHPPL‐3 with CHPPL‐5 and Dycal (p < .05), and CHPPL‐3 with N‐MTA (p < .05). A thin layer of mineralized tissue formation (MTF) was observed in all groups. At day 28, CHPPL‐1, Dycal, and N‐MTA showed no to mild inflammation, whilst CHPPL‐3, CHPPL‐5, and NC exhibited mild to severe inflammation, and statistically significant difference was detected (p < .05). CHPPL‐1, Dycal, and N‐MTA exhibited continuous MTF, whilst CHPPL‐3, CHPPL‐5, and NC had thicker and interrupted MTF. Significant differences were observed between CHPPL‐1, CHPPL‐3, and N‐MTA with NC group (p < .05). Variable expressions of IL‐6, Nestin, and DMP‐1 indicated differences in the materials' impact on odontoblast‐like cell formation and tissue mineralization.ConclusionsThese findings suggest that CHPPL‐1 has the potential to minimize pulpal inflammation and promote MTF and had similar efficacy as MTA cement.

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