Effects of a Minimum Interval Immunization Schedule for Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccination During a Pertussis Outbreak

Abstract

To examine the impact of a minimum interval schedule for administering diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP) in infants during a statewide pertussis outbreak on receipt of inactivated polio vaccine (IPV) and pneumococcal conjugate vaccine (PCV).

Potential impact of accelerating the primary dose of rotavirus vaccine in infants

“…23 Study of a pertussis outbreak in Arizona resulted in the finding that the proportion of infants who completed the primary series of DTaP (along with the other routine vaccines) within the first 6 months of life was higher for those who received vaccines at the minimal dosing interval than at the standard interval. 24 Similarly, early administration of the pneumococcal conjugate vaccine could prevent approximately 100 cases of invasive pneumococcal disease among young infants in the United States. 25 …”

Evaluation of the frequency of immunization information system use for public health research

“…The most number of manuscripts were affiliated with a university (n = 16), 12,16,17,19,20,24,25,27,[32][33][34]36,40,41,48,55 followed by affiliations with a health department (n = 9). 14,20,22,30,31,38,46,47,49 Other affiliations included the CDC (n = 8), 18 want to use the IIS data for research purposes could be advised to seek such a relationship. There are other possible barriers to the use of IIS data, including concerns regarding confidentiality, data quality and budget constrictions, but further research is needed in this area.…”

“…28,29,43,44 The Policy implementation/change category included 11 papers, including one that described the coverage of a new vaccine compared with an older vaccine, 30 one that examined recommended ages, 35 two that examined the impact of a policy change, 36,37 and 7 that evaluated an intervention. [31][32][33][34][45][46][47] Two manuscripts described a response to short-term vaccine supply issues, including the impact of an outbreak 38 and a shortage. 39 There were six papers in the reminder/recall group, with three papers evaluating the use of an IIS in a vaccine recall 40,48,49 and three evaluating the use of IIS in vaccination reminders.…”

Old Disease, Innovative Response

“…The improvements in overall vaccination rates were also present during the nonoutbreak period, although the magnitude of improvement was less during this nonepidemic period. 11 This finding is important because advisory bodies have not traditionally recommended use of a minimal interval or accelerated schedule of vaccination for infants during pertussis outbreaks because it would not match the schedule of other recommended vaccinations. In the worst-case scenario, the number of cases of other vaccine-preventable diseases would also increase, compounding the medical consequences of the original pertussis outbreak.…”

“…The study by Bronson-Lowe and Anderson, 11 and other articles in the May issue of the Archives of Pediatrics & Adolescent Medicine, are reminders that there are innovative ways to promote immunization and administer vaccines that offer the opportunity to obtain additional benefits from these familiar tools.…”