Effects of a mixture of Citri Pericarpium and Scutellariae Radix on acute reflux esophagitis in rats

이, 진아; 신, 미래; 노, 성수; 박, 해진

doi:10.4163/jnh.2021.54.3.321

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…In this study, the effect on reflux esophagitis was confirmed by mixing Scutellariae Radix and Citri Reticulatae Pericarpium, which contain various flavone components and are known to have an excellent effect on inflammation. As a result of previous studies, it was confirmed that the Scutellariae Radix and Citri Reticulatae Pericarpium mixture (SC) alleviated the damage to the esophageal mucosa in acute reflux esophagitis, and in this experiment [ 16 ], the effect of SC on chronically advanced reflux esophagitis and its mechanism were confirmed. SC treatment significantly reduced the degree of esophageal mucosal damage, significantly reduced levels of MDA and MPO, and inhibited the activation of the NF- κ B inflammatory pathway by activating the PPAR γ /RXR pathway.…”

Section: Discussionsupporting

confidence: 64%

“…The aim of this study was to determine whether a Scutellariae Radix and Citri Reticulatae Pericarpium mixture (SC) could alleviate esophageal mucosal injury as a result of chronic acid reflux esophagitis. As a result of the previous study, it was confirmed that SC alleviated the damage to the esophageal mucosa in acute reflux esophagitis [ 16 ], and furthermore, the mechanism for the effect in chronic reflux esophagitis was confirmed.…”

Section: Introductionmentioning

confidence: 65%

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Scutellariae Radix and Citri Reticulatae Pericarpium Mixture Regulate PPARγ/RXR Signaling in Reflux Esophagitis

Lee

Shin

Park

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Gastroesophageal reflux disease (GERD) is a gastrointestinal disorder in which stomach contents reflux into the esophagus, causing complications such as mucosal damage. GERD is a very common disease and is on the rise worldwide. The aim of this study was to assess the impact of a Scutellariae Radix and Citri Reticulatae Pericarpium mixture (SC) on esophageal mucosal injury in rats with chronic acid reflux esophagitis (CARE). Methods. After inducing reflux esophagitis through surgery, the group was separated and the drug was administered for 2 weeks: normal rats (Normal, n = 8), CARE-induced rats were treated with distilled water (Control, n = 8), CARE-induced rats were treated with vitamin E 30 mg/kg body weight (VitE, n = 8), CARE-induced rats were treated with SC 100 mg/kg body weight (SC100, n = 8), and CARE-induced rats were treated with SC 200 mg/kg body weight (SC200, n = 8). Results. SC treatment significantly reduced the degree of esophageal mucosal damage, significantly reduced levels of MDA and MPO, and inhibited the activation of the NF-κB inflammatory pathway by activating the PPARγ/RXR pathway. In addition, SC treatment significantly regulated the expression of arachidonic acid-related proteins (COX-1, COX-2, and PGE2) and modulated the MMP/TIMP proteins in reflux esophagitis. Conclusion. Consequently, SC improved the damage to the esophageal mucosa. Also, the anti-inflammatory effects of the SC suggested the inhibition of NF-κB pathway through the activation of the PPARγ/RXR pathway, thereby reducing the expression of inflammation-related cytokines.

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Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 65%