Effects of a moderate-intensity aerobic program on blood viscosity, platelet aggregation and fibrinolytic balance in young and middle-aged sedentary subjects

Coppola, Ludovico; A, Grassia; Coppola, Angelo; Tondi, Giovanna; Peluso, Giuseppina; Mordente, Salvatore; Gombos, G.

doi:10.1097/00001721-200401000-00006

Cited by 26 publications

(14 citation statements)

References 37 publications

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“…However, two studies showed that aerobic exercise significantly increases platelet count (34,35). Inconsistent with our findings, Coppola et al reported that aerobic training significantly reduces platelet count (36). These inconsistencies could be related to gender of the participants, duration of the exercise, and type of exercise.…”

Section: Resultscontrasting

confidence: 77%

Effect of Eight Weeks of Aerobic Exercise on Iron Status and Coagulation and Immune Indices in Non-Athlete Females

et al. 2018

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Background and objectives: The aim of this study was to investigate the effect of eight weeks of aerobic exercise on serum iron, serum ferritin, platelet count, mean platelet volume, and some immunity indices in non-athlete females.Methods: In this study, 30 non-athlete females aged 30-45 years were randomly divided into an experimental and a control group. The experimental group was subjected to perform aerobic exercise at 60-70% of maximal heart rate for eight weeks, three sessions per week and one hour per session. Blood parameters were measured before the exercise program and after the completion of program by taking 2 ml blood samples from the venous vein of the participants in the sitting position. Finally, t-test was used to compare the pretest and post-test means of each group and independent t-test was used to compare the two groups at significance of 0.05.Results: After eight weeks of aerobic exercise, there was a significant increase in mean platelet volume and a significant decrease in serum iron and ferritin levels in the experimental group (P <0.05). There was a slight decrease in the number of platelets, white blood cells, granulocytes, monocytes and lymphocytes (P<0.05).Conclusion: We recommend physical education instructors, athletes and nonathletes to consider iron supplementation during aerobic exercise, and modify appropriate training intensity based on the fitness and age of trainees to prevent risk of anemia.

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Section: Resultscontrasting

confidence: 77%

Effect of Eight Weeks of Aerobic Exercise on Iron Status and Coagulation and Immune Indices in Non-Athlete Females

et al. 2018

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“…While 10 d of aerobic exercise had no effect on arterial function of obese subjects with metabolic syndrome [7], 8 wk of moderate-intensity exercise by obese and insulin resistant individuals decreased plasma viscosity; however, blood viscosity, plasma fibrinogen, RBC aggregation and RBC deformability remained unchanged [33]. Coppola et al [30] reported that twelve wk of moderate-intensity treadmill exercise reduced blood viscosity at high (450 s −1 ) and moderate (90 s −1 ) shear rates in older, sedentary individuals. Consequently, the limited studies investigating the effects of exercise training in individuals at risk for metabolic disorders indicates that plasma viscosity may improve within 8 wk of aerobic exercise training, while at least 12-wk of exercise training is required to induce beneficial changes in blood viscosity.…”

Section: Metabolic Diseasementioning

confidence: 99%

Exercise hemorheology: Classical data, recent findings and unresolved issues

Connes

Simmonds

Brun

et al. 2013

Clinical Hemorheology and Microcirculation

125

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The present review focuses on the past and recent knowledge in the field of exercise hemorheology and presents some unresolved issues for opening discussion. Acute exercise is associated with a rise in hematocrit which results in an increase in blood viscosity. Whereas increased blood viscosity was previously viewed as having negative consequences for cardiovascular function and aerobic performance, recent findings suggest dynamic changes in blood viscosity might be useful for vascular function during exercise by increasing nitric oxide production. Other determinants of blood viscosity are altered by exercise (e.g., decreased red blood cell deformability, increased red blood cell aggregation and plasma viscosity) and may, independent of the associated effect on blood viscosity, directly modulate aerobic capacity. However, the data published on the effects of exercise on the hemorheology are not consistent, with some studies showing decreased, unchanged, or increased red blood cell deformability/aggregation when compared with rest. These discrepancies seem to be related to the exercise protocol investigated, the population tested or the methodogy utilized for hemorheological measurements. Finally, this review focuses on the effects of exercise training (i.e. chronic physical activity) on the hemorheological profile of healthy individuals and patients with cardiovascular and metabolic disorders. P. Connes et al. / Blood rheology and exerciseaddress classical findings in exercise hemorheology and will present new directions. In addition, some unresolved issues will be presented for opening discussion. Acute effects of exercise on hemorheology and relationships with performance2.1. Blood viscosity P. Connes et al. / Blood rheology and exercise 189 PRE 90 Blood viscosity (mPa/s) POST 90 POST 225 5 6 7 8 9

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“…First, elite athletes increasingly undertake extended travel for training and competition, potentially exposing them to an increased risk of travel-related thrombosis. 22,30 However, this may be compensated by mitigating characteristics typical of endurance-trained athletes such as increased plasma volume, 31 decreased blood viscosity, 32 and remodeled vascular structures, 33 perhaps providing little reason to assume that the risk for the athlete would be any greater than for the average person. In contrast, the nature of some sports may impose long periods of compression on specific blood vessels due to equipment or posture or may lead to inflammation or the overdevelopment of musculature that may impinge upon the vasculature, as occurs in Paget-Shroetter syndrome.…”

Section: Is the Risk Of Thrombosis Greater In The Elite Athlete?mentioning

confidence: 99%

Exercise in the Fight Against Thrombosis: Friend or Foe?

Adams

Williams

Fell

2009

Semin Thromb Hemost

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Thrombosis is a major cause of morbidity and mortality in Western countries and is associated with a range of chronic diseases such as cardiovascular disease, renal disease, diabetes, and various autoimmune conditions. Improved health care and approaches to the treatment of disease are leading to aging populations that will probably result in an increase in the incidence of thrombosis and associated manifestations over the next few decades. Adopting a physically active lifestyle through regular exercise has been proposed to lower the risk of developing thrombosis. Indeed, it has been demonstrated that exercise is beneficial for health, although there is inconsistent data from studies investigating the effect of exercise on the risk of thrombosis, with reports of both increased and decreased risk across a variety of cohorts. Studies in this area are difficult to critique due to the variety of confounders such as age, body composition, fitness level, underlying disease and treatment, as well as exercise intensity, frequency, duration, and energy expenditure. In younger individuals and those with chronic conditions such as cardiovascular and kidney disease, there is evidence that physical activity is beneficial for the lowering of thrombotic risk, whereas in older individuals the risk is more likely to be unchanged or increased. This review will explore whether exercise is a "friend" or "foe" in lowering the risk of thrombosis. It will also discuss whether elite athletes have a lower risk of thrombosis and whether exercise may help to reduce thrombotic risk in individuals with chronic disease.

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Effects of a moderate-intensity aerobic program on blood viscosity, platelet aggregation and fibrinolytic balance in young and middle-aged sedentary subjects

Cited by 26 publications

References 37 publications

Effect of Eight Weeks of Aerobic Exercise on Iron Status and Coagulation and Immune Indices in Non-Athlete Females

Effect of Eight Weeks of Aerobic Exercise on Iron Status and Coagulation and Immune Indices in Non-Athlete Females

Exercise hemorheology: Classical data, recent findings and unresolved issues

Exercise in the Fight Against Thrombosis: Friend or Foe?

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