Effects of a multi-component camp-based intervention on inflammatory markers and adipokines in children: A randomized controlled trial

Abstract

This file was dowloaded from the institutional repository Brage NIH -brage.bibsys.no/nih Huang, T., Larsen, K. T., Møller, N. C., Ried-Larsen, M., Frandsen, U., Andersen, L. B. (2015 Methods:One hundred and fifteen children were recruited in Odense, Denmark (2011Denmark ( -2014. The participants were randomly allocated to either the day camp intervention arm (DCIA) or the standard intervention arm (SIA). The intervention for the DCIA comprised a 6-week camp intervention and a 46-week family-based intervention. The SIA was offered one weekly physical activity session for 6 weeks and one educational meeting. C-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP1), leptin, and adiponectin were measured in serum at baseline, 6 weeks and 52 weeks.Results: Compared with the SIA, the reductions in CRP (P=0.003) and leptin (p<0.001) were larger in the DCIA at 6 weeks. The intervention effects on leptin were significantly mediated by the changes in body fat mass. No intervention effects on CRP and leptin were seen at 52 weeks. No between-group differences in changes in MCP1 and adiponectin were observed at 6 weeks or 52 weeks. Conclusions:The 6-week camp intervention resulted in reductions in CRP and leptin. The intervention effects did not persist to 52 weeks. The intervention effect on leptin was explained by the changes in body fat mass.

Uric acid and gamma‐glutamyl‐transferase in children and adolescents with obesity: Association to anthropometric measures and cardiometabolic risk markers depending on pubertal stage, sex, degree of weight loss and type of patient care: Evaluation of the adiposity patient follow‐up registry

“…Our results are in line with previous studies, such as the HELENA study and studies from other groups, 23,40–44 which have also shown that obesity related inflammation may occur long before the onset of puberty. The fact that some of the observed associations were strongest in prepubertal children underlines and confirms the importance of identifying children at risk and initiating therapy as early as possible.…”

Adiponectin, Inflammation and Cardiometabolic Risk Factors in Paediatric Obese Patients: Impact of Interventional Studies

“…Contrarily, a 12-week exercise intervention study with lean adolescents males found an increase in adiponectin, IL-6 and CRP, although none of these changes were associated with variations in body fat composition [110]. Similar results were found in other studies [111].…”

Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight

“…One study was a non-randomised trial (Halberstadt 2017);Seven studies did not report the disaggregated data for children with obesity or overweight (Donnelly 2009; Donnelly 2013; Gentile 2009; Hillman 2014; Murray 2008; Puder 2011; Reed 2010);Two studies employed lifestyle interventions without the intention to prevent or reduce obesity (Crova 2014; Pesce 2016b);Eight studies used non-eligible tools to assess school or cognitive outcomes (e.g. self-reported or parent-reported questionnaires) (Gee 2014; Goldfield 2012; Muzaffar 2014; Naar-King 2016; Pentz 2011; Salmoirago-Blotcher 2015; Smith 2015; Wong 2016).…”

“…Seven studies did not report the disaggregated data for children with obesity or overweight (Donnelly 2009; Donnelly 2013; Gentile 2009; Hillman 2014; Murray 2008; Puder 2011; Reed 2010);…”