Effects of a multifactorial intervention comprising resistance exercise, nutritional and psychosocial programs on frailty and functional health in community‐dwelling older adults: A randomized, controlled, cross‐over trial

Seino, Satoshi; Nishi, Mariko; Murayama, Hiroshi; Narita, Miki; Yokoyama, Yuri; Nofuji, Yu; Taniguchi, Yu; Amano, Hidenori; Kitamura, Akihiko; Shinkai, Shoji

doi:10.1111/ggi.13016

Cited by 73 publications

(166 citation statements)

References 26 publications

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“…Initiatives such as group activities, goal setting, and checklists may also help improve nutritional status by encouraging consumption of a properly balanced diet. [35,74] Three studies included CGA or CGA-like strategies as an intervention,[36, 75,76] incorporating tools such as preventive home visits, multi-professional group meetings to discuss patients' care, and treatments being prescribed based on individual need. Our meta-analysis suggests that this tailored approach is successful in reducing frailty prevalence but it is difficult to ascertain whether a specific component was responsible for improvement, or if there was a combinatorial effect, due to the varied needs of the individuals taking part in those studies.…”

Section: Implications For Clinical Practicementioning

confidence: 99%

Primary care interventions to address physical frailty among community-dwelling adults aged 60 years or older: A meta-analysis

et al. 2020

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IntroductionThe best interventions to address frailty among older adults have not yet been fully defined, and the diversity of interventions and outcome measures makes this process challenging. Consequently, there is a lack of guidance for clinicians and researchers regarding which interventions are most likely to help older persons remain robust and independent. This paper uses meta-analysis to assess effectiveness of primary care interventions for physical frailty among community-dwelling adults aged 60+ and provides an up-to-date synthesis of literature in this area. MethodsPubMed, CINAHL, Cochrane Register of Controlled Trials, and PEDro databases were searched, and RCTs, controlled pilot studies, or trials with similar study designs addressing frailty in the primary care setting among persons aged 60+ were chosen. Study data was abstracted following PRISMA guidelines, then meta-analysis was performed using the random effects model. OPEN ACCESS Citation: Macdonald SH-F, Travers J, Shé ÉN, Bailey J, Romero-Ortuno R, Keyes M, et al. (2020) Primary care interventions to address physical frailty among community-dwelling adults aged 60 years or older: A meta-analysis. PLoS ONE 15(2): e0228821. https://doi.org/10.1371/journal.

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Section: Implications For Clinical Practicementioning

confidence: 99%

Primary care interventions to address physical frailty among community-dwelling adults aged 60 years or older: A meta-analysis

et al. 2020

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“…When frailty is suspected, the underlying disease should be identified and managed in a clinical setting, and a multifactorial intervention comprising resistance exercise, protein-rich food intake and a psychosocial program should be used to improve frailty. 30 In conclusion, the present prospective study of Japanese older adults shows that the risks of death and disability in individuals with mild diabetes are strongly affected by the presence of frailty. The risks of all-cause mortality and incident disability among frail adults with diabetes were 5.0-and 3.9-fold, respectively, those of non-frail adults without diabetes.…”

Section: Discussionmentioning

confidence: 61%

“…Furthermore, the present study has practical implications for frailty assessment of older adults at community‐based health checkups, regardless of diabetes status. When frailty is suspected, the underlying disease should be identified and managed in a clinical setting, and a multifactorial intervention comprising resistance exercise, protein‐rich food intake and a psychosocial program should be used to improve frailty …”

Section: Discussionmentioning

confidence: 99%

Combined effect of diabetes and frailty on mortality and incident disability in older Japanese adults

Kitamura

Taniguchi

Seino

et al. 2019

Geriatrics Gerontology Int

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AimEvidence is limited on how frailty affects the association between diabetes and adverse outcomes at the population level. The present community‐based study aimed to clarify the relative risks of death and disability in older Japanese adults with diabetes, frailty, both or neither.MethodsThe present prospective study analyzed data from 1271 Japanese residents aged ≥65 years in Kusatsu town in Gunma Prefecture, Japan, who participated in annual health checkups carried out between 2002 and 2011, and were initially free of disability. A Cox proportional hazards regression model was used to identify associations of diabetes and frailty with all‐cause mortality and incident disability.ResultsAmong the 1271 participants, 176 (14%) had diabetes (mean hemoglobin A1c 7.5%, body mass index 24.2 kg/m2, 45% using diabetes medications) and 151 (12%) had frailty at baseline. Compared with non‐frail participants without diabetes, those with diabetes and frailty had higher risks of mortality (multivariable hazard ratio 5.0, 95% CI 2.4–10.3) and incident disability (hazard ratio 3.9, 95% CI 2.1–7.3). In contrast, non‐frail participants with diabetes did not have a significantly increased risk of mortality, although they had a higher tendency for the incidence of disability, as compared with non‐frail participants without diabetes.ConclusionsAt the population level, the risks of death and disability in persons with mild diabetes were strongly affected by the presence of frailty. From a community‐based perspective, diabetes‐related mortality and disability incidence might be reduced by preventing or improving frailty in conjunction with glycemic control. Geriatr Gerontol Int 2019; 19: 423–428.

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“…It has been reported that exercise improves memory function in mice, including AD model mice, by triggering hippocampal neurogenesis and increasing brain‐derived neurotrophic factor expression . In addition, physical activity reduces the risk of cardiovascular disease, and prefrail or frail older adults can reduce frailty by performing interventions combining resistance exercise, nutritional education, and psychosocial programs . This is also expected to improve cognitive function, advance physical function, and promote health through physical activity.…”

Section: Discussionmentioning

confidence: 99%

“…15 In addition, physical activity reduces the risk of cardiovascular disease, 16 and prefrail or frail older adults can reduce frailty by performing interventions combining resistance exercise, nutritional education, and psychosocial programs. 17 This is also expected to improve cognitive function, advance physical function, and promote health through physical activity. However, it is also important to select subjects who will benefit the most from these activities.…”

Section: By Comparing Changes In Tdas Scores and Physical Function Tementioning

confidence: 99%

A program of exercise, brain training, and lecture to prevent cognitive decline

Kouzuki

Kato

Wada‐Isoe

et al. 2020

Ann Clin Transl Neurol

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Objective We examined the benefits of a community‐based program combining physical exercise, cognitive training, and education on dementia and lifestyle habits. Methods This crossover open‐label trial included 141 community‐dwelling elderly people with suspected mild cognitive decline (MCD). Subjects were assigned to a 6‐month intervention‐first/6‐month observation‐second (INT‐OBS) group or an OBS‐INT group. The 6‐month intervention consisted of 2 h of physical exercise, cognitive training, and classroom study or rest once weekly. Primary outcome was change in Touch Panel‐type Dementia Assessment Scale (TDAS) score. Results TDAS score improved significantly during the intervention period compared with the observation period for all subjects (P < 0.05). Some physical functions also improved significantly during the intervention period compared with the observation period in the OBS‐INT group (P < 0.05). Interpretation This community‐based program improved both cognitive and physical function in elderly people with suspected MCD.

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Effects of a multifactorial intervention comprising resistance exercise, nutritional and psychosocial programs on frailty and functional health in community‐dwelling older adults: A randomized, controlled, cross‐over trial

Abstract: This 3-month multifactorial intervention reduced frailty and improved functional health. These intervention effects persisted for at least 3 months post-intervention. Geriatr Gerontol Int 2017; 17: 2034-2045.

Cited by 73 publications

References 26 publications

Primary care interventions to address physical frailty among community-dwelling adults aged 60 years or older: A meta-analysis

Primary care interventions to address physical frailty among community-dwelling adults aged 60 years or older: A meta-analysis

Combined effect of diabetes and frailty on mortality and incident disability in older Japanese adults

A program of exercise, brain training, and lecture to prevent cognitive decline

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