Effects of a mushroom mycelium extract on the treatment of prostate cancer

White, Ralph W. deVere; Hackman, Robert M.; Soares, Stephanie; Beckett, Laurel A.; Sun, Bo

doi:10.1016/s0090-4295(02)01856-3

Cited by 66 publications

(19 citation statements)

References 15 publications

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“…What perhaps was more intriguing was that the supplementation appeared to have favorable effects on chemotherapy-related side effects such as loss of appetite, alopecia, emotional instability, and general weakness, as quantified by a questionnaire. In the single published clinical trial with Lentinula extract in cancer, use of this treatment was not associated with a lowering of PSA values in any of the 62 patients 83 ; rather than choosing a reduction in PSA as the end point, it would have been more illuminating to look at the impact of therapy on the PSA doubling time, as employed in the MCP study cited above.…”

Section: Boosting Immune Defenses: Focus On Natural Killer Cellsmentioning

confidence: 99%

Toward a Core Nutraceutical Program for Cancer Management

McCarty

Block

2006

Integr Cancer Ther

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As previously suggested, it may be feasible to impede tumorevoked angiogenesis with a nutraceutical program composed of glycine, fish oil, epigallocatechin-3-gallate, selenium, and silymarin, complemented by a low-fat vegan diet, exercise training, and, if feasible, a salicylate and the drug tetrathiomolybdate. It is now proposed that the scope of this program be expanded to address additional common needs of cancer patients: blocking the process of metastasis; boosting the cytotoxic capacity of innate immune defenses (natural killer [NK] cells); preventing cachexia, thromboembolism, and tumor-induced osteolysis; and maintaining optimal micronutrient status. Modified citrus pectin, a galectin-3 antagonist, has impressive antimetastatic potential. Mushroom β-glucans and probiotic lactobacilli can amplify NK activity via stimulatory effects on macrophages. Selenium, β-carotene, and glutamine can also increase the number and/or cytotoxic activity of NK cells. Cachectic loss of muscle mass can be opposed by fish oil, glutamine, and β-hydroxy-β-methylbutyrate. Fish oil, policosanol, and vitamin D may have potential for control of osteolysis. High-dose aspirin or salicylates, by preventing NF-κB activation, can be expected to aid prevention of metastasis and cachexia while down-regulating osteolysis, but their impacts on innate immune defenses will not be entirely favorable. A nutritional insurance formula crafted for the special needs of cancer patients can be included in this regimen. To minimize patient inconvenience, this complex core nutraceutical program could be configured as an oil product, a powder, and a capsule product, with the nutritional insurance formula provided in tablets. It would be of interest to test this program in nude mouse xenograft models.

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Section: Boosting Immune Defenses: Focus On Natural Killer Cellsmentioning

confidence: 99%

Toward a Core Nutraceutical Program for Cancer Management

McCarty

Block

2006

Integr Cancer Ther

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“…Details of the 18 excluded studies are given in Table 2 [4,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41].…”

Section: Description Of Studiesmentioning

confidence: 99%

Phytotherapeutic interventions in the management of biochemically recurrent prostate cancer: a systematic review of randomised trials

et al. 2016

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ObjectiveTo evaluate the evidence from randomised trials for the efficacy and safety of phytotherapeutic interventions in the management of biochemically recurrent (BCR) prostate cancer, indicated by prostate-specific antigen (PSA) progression, numbers progressing to/time to initiation of androgen-deprivation therapy or salvage therapy. Patients and MethodsMEDLINE (Ovid), EMBASE (Ovid), AMED (Ovid), CINAHL (EBSCO) and the Cochrane Library databases were searched. Clinical trials investigating phytotherapeutic interventions as dietary supplements or dietary components, including multicomponent herbal formulations, in men with BCR prostate cancer were located. Eight of nine authors contacted for further information responded. Methodological quality was assessed using the Cochrane Collaboration's risk of bias assessment tool. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement for reporting systematic reviews was followed. ResultsOf 23 full-text articles assessed for eligibility, five met the criteria for inclusion. Two studies were placebo controlled; two were active control trials; and one a high-/low-dose trial. The interventions were administered as isolated phytochemicals (sulphoraphane), phytotherapeutic extracts [Pomi-T (pomegranate, turmeric, green tea and broccoli sprout extract), soy, lycopene, and POMx (pomegranate extract)], or plant-derived dietary items (soy and lycopene). All studies found serum PSA levels to stabilise, decrease or rise more slowly in a significant number of men, and three studies reported stabilising or lengthening of PSA-doubling time. Studies were generally of good quality, but sample sizes were predominantly small, and durations short. ConclusionsHigh-quality studies in this area are lacking. Sulphoraphane, lycopene, soy isoflavones, POMx, and Pomi-T are safe and well tolerated. There is limited evidence that they can affect PSA dynamics. No recommendation can be made for the use of these agents in managing prostate cancer morbidity and mortality until high-quality, fully powered studies are available. Recommendations are made for improving reproducibility and translation of findings with regard to study population, study endpoints, design, and the reporting of phytotherapeutic interventions.

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“…Evidence strongly implicates diet as a factor in the development and progression of prostate cancer (CaP) and in the present debate on the mixed benefits of routine screening for CaP and immediate treatment for all men diagnosed(2–6), diet change may represent an important modifiable risk factor(7–9). As such it may be a valuable self-care cancer survivorship strategy and give some sense of personal control and hope to men(10). …”

Section: Introductionmentioning

confidence: 99%

A Novel Measure of Dietary Change in a Prostate Cancer Dietary Program Incorporating Mindfulness Training

Carmody

Olendzki²,

Merriam³

et al. 2012

Journal of the Academy of Nutrition and Dietetics

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Diet may represent a modifiable prostate cancer (CaP) risk factor, but a vegetable-based prostate-healthy diet is a major change for most men. We used a ratio of animal:vegetable proteins (A:V ratio) to evaluate whether a comprehensive dietary change was self-sustaining following completion of 11 weekly dietary and cooking classes that integrated mindfulness training (MT). Thirty-six men with recurring CaP were randomized to the intervention or wait-list control. Assessments were at baseline, three months and six months. Of the 17 men randomized to the intervention, 14 completed the requirements. Nineteen were randomized to control and 17 completed requirements. Compared to controls, a significant post-intervention (3 months) decrease in A:V ratio in the intervention group (p=.01) was self-maintained 3 months post-intervention (p=0.049). At each assessment, the A:V ratio was correlated with lycopene, fiber, saturated fat, and dietary cholesterol; four dietary components linked to clinically relevant outcomes in CaP. Change in A:V ratio was also significantly correlated with changes in fiber, saturated fat and dietary cholesterol intake. Participants reported regular MT practice and there was a significant correlation between MT practice and changes in both initiation and maintenance of the change in the A:V ratio. These pilot results provide encouraging evidence for the feasibility of a dietary program that includes MT in supporting dietary change for men with recurrent CaP and invite further study to explore the possible role of MT as a means of supporting both initiation of dietary changes and maintenance of those changes over time.

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Effects of a mushroom mycelium extract on the treatment of prostate cancer

Cited by 66 publications

References 15 publications

Toward a Core Nutraceutical Program for Cancer Management

Toward a Core Nutraceutical Program for Cancer Management

Phytotherapeutic interventions in the management of biochemically recurrent prostate cancer: a systematic review of randomised trials

A Novel Measure of Dietary Change in a Prostate Cancer Dietary Program Incorporating Mindfulness Training

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