Effects of a Novel Chitosan Gel on Mucosal Wound Healing Following Endoscopic Sinus Surgery in a Sheep Model of Chronic Rhinosinusitis

Athanasiadis, Theo; Beule, Achim G.; Robinson, Brian H.; Robinson, Simon; Shi, Zheng; Wormald, Peter‐John

doi:10.1097/mlg.0b013e31816ba576

Cited by 80 publications

(75 citation statements)

References 43 publications

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“…The development of a CD based hydrogel has led to a product suitable for surgical applications. This gel may be tailored to suit different areas of application and has shown to be effective in both haemostasis and adhesion reduction when used in the nasal cavity [9,10]. In this preliminary study, we demonstrate that a CD gel is well tolerated as an intra-abdominal agent with a highly statistically significant reduction in adhesion formation and with no increased risk of enterotomy dehiscence when compared to control groups.…”

Section: Discussionmentioning

confidence: 71%

Use of a Modified Chitosan–Dextran Gel to Prevent Peritoneal Adhesions in a Rat Model

Lauder

Garcea

Strickland

et al. 2011

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 71%

Use of a Modified Chitosan–Dextran Gel to Prevent Peritoneal Adhesions in a Rat Model

Lauder

Garcea

Strickland

et al. 2011

Journal of Surgical Research

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“…B. mit einer K ü rette oder einem B ü rstenabstrich [134] ) unter einem Doppel-Kontrast-Mikroskop bestimmen. Messergebnisse dieses h ä ufi g in der Literatur angewendeten Verfahrens [47,135] sollten ü ber die Werte von mindestens vier zilientragenden Zellen gemittelt werden. Zur Erh ö hung der Reliabilit ä t und schnelleren Auswertung wurde die Messung mit einer speziellen digitalen Photometrie empfohlen [136] .…”

Section: In-vitro-tests F ü R Komponenten Der Mukozili ä Ren Clearanceunclassified

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

Beule¹

2010

Laryngo-Rhino-Otol

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In this review, anatomy and physiology of the respiratory mucosa of nose and paranasal sinuses are summarized under the aspect of its clinical significance. Basics of endonasal cleaning including mucociliary clearance and nasal reflexes, as well as defence mechanisms are explained. Physiological wound healing, aspects of endonasal topical medical therapy and typical diagnostic procedures to evaluate the respiratory functions are presented. Finally, the pathophysiologies of different subtypes of non-allergic rhinitis are outlined together with treatment recommendations.

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“…Chitosan-dextran hydrogel (CDH) has been developed as a postoperative dressing to be used in endoscopic sinus surgery, and has been used in animal [Athanasiadis et al, 2008;Medina et al, 2012] and human trials [Valentine et al, 2010]. In these studies, it significantly reduced the number of adhesions and exhibited excellent hemostatic, mucoadhesive, and antimicrobial properties [Aziz et al, 2012].…”

Section: Introductionmentioning

confidence: 99%

Safety and Efficacy of Chitosan-Dextran Hydrogel in the Middle Ear in an Animal Model

Ünsaler

Başaran²,

Sarı³

et al. 2016

Audiol Neurotol

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Objectives: To investigate the efficacy of chitosan-dextran hydrogel (CDH) in preventing postoperative adhesions between the tympanic membrane (TM) and intratympanic structures, and to evaluate its ototoxicity in an animal study. Methods: In the first step, ototoxicity was evaluated with 7 male albino guinea pigs (GPs) via auditory brainstem responses (ABR) before and 4 weeks after unilateral intratympanic injection of CDH and saline solution contralaterally. In the second step, 12 GPs underwent bilateral ear surgery. The middle ear (ME) mucosa was abraded, and the cavity was filled with CDH on one side and packed with Gelfoam on the contralateral side. A control group of 6 GPs underwent the same procedure except that no material was applied in the ME. The animals were euthanized at the end of the 7th week, and otomicroscopic findings were noted and the temporal bones harvested for the histologic examination. The findings were scored and compared. Results: There was no statistically significant difference between the pre- and postoperative ABR thresholds. In the otomicroscopic findings, the most prominent difference between the two groups was the presence of retraction of the TM in the Gelfoam group. The histopathologic findings revealed a higher degree of inflammation in the Gelfoam group compared with the CDH group. Conclusion: This study demonstrated that CDH has no ototoxic effects in GPs. Its use as an ME packing material revealed significantly less TM retraction and inflammatory reaction compared with Gelfoam.

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Effects of a Novel Chitosan Gel on Mucosal Wound Healing Following Endoscopic Sinus Surgery in a Sheep Model of Chronic Rhinosinusitis

Abstract: In the sheep model of chronic sinusitis, CD significantly improves microscopic wound healing and reduces adhesion formation after ESS.

Cited by 80 publications

References 43 publications

Use of a Modified Chitosan–Dextran Gel to Prevent Peritoneal Adhesions in a Rat Model

Use of a Modified Chitosan–Dextran Gel to Prevent Peritoneal Adhesions in a Rat Model

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

Safety and Efficacy of Chitosan-Dextran Hydrogel in the Middle Ear in an Animal Model

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