1996
DOI: 10.1002/(sici)1097-0061(19960330)12:4<349::aid-yea917>3.3.co;2-f
|View full text |Cite
|
Sign up to set email alerts
|

Effects of a Novel DNA‐Damaging Agent on the Budding Yeast Saccharomyces cerevisiae Cell Cycle

Abstract: We have investigated the effects on Saccharomyces cerevisiae of a novel antitumour agent (FCE24517 or Tallimustine) which causes selective alkylations to adenines in the minor groove of DNA. Tallimustine, added to wild-type cells for short periods, reduced the growth rate and increased the percentage of budded cells and delayed the cell cycle in the late S + G2 + M phases. In the rad9 delta null mutant cells, Tallimustine treatment did not affect growth rate and the percentage of budded cells but greatly reduc… Show more

Help me understand this report

This publication either has no citations yet, or we are still processing them

Set email alert for when this publication receives citations?

See others like this or search for similar articles