Effects of a nurse-led medication self-management programme in women with oral treatments for metastatic breast cancer: A mixed-method randomised controlled trial

Improving quality of life and symptom experience in patients with metastatic breast cancer: A systematic review of supportive care interventions

“…Two RCTs investigated self‐management support interventions, with 75 and 155 participants respectively 33 ,. 42 One trial evaluated the effect of an intervention based around a mobile game, in which the avatar was generated using the patient's medical information. The avatar carried out tasks such as visiting the pharmacy or hospital, cooking appropriate food, exercising and carrying out quests to minimise treatment side‐effects 33 .…”

“…The study duration was 3 weeks for the game‐based intervention and 2 months for the patient centered program, however, the patient centered program was administered once a month, while participants with the educational game were encouraged to play at least three times per week. The mobile game intervention was home‐based and remote whilst the setting of the second intervention was not reported 33,42 . The primary outcome of both studies was compliance to medication.…”

“…33,42 There was no significant impact reported for symptoms of anxiety, depression 33 or for symptom severity. 42…”

Systematic review of real-world studies evaluating the impact of medication non-adherence to endocrine therapies on hard clinical endpoints in patients with non-metastatic breast cancer

“…With accumulating knowledge on the consequences of medication non-adherence/non-persistence on clinical outcomes, a need emerges for systematic health economic evidence that estimates the health and economic consequences of medication adherence enhancing interventions (MAEIs). Increasing awareness of poor adherence to endocrine therapies in early and metastatic breast cancer has led to the development of numerous MAEIs (including patient education-and nurse-led programs, and digital health applications) in the last few years [59][60][61][62][63][64][65]. However, recent systematic literature reviews on MAEIs conducted in breast cancer (and also in other diseases) showed thatat least based on existing evidence -a firm conclusion cannot be drawn on the efficacy of these interventions [66][67][68].…”

Stakeholders' perceptions of a community‐based advanced nurse practitioner‐led integrated oncology care model for adults receiving oral anti‐cancer medication—A qualitative study

“…These safety concerns are of particular importance as OAMs have the same risks as SACT given parenterally in terms of toxicities or serious medication errors (NCCP, 2018). The absence of direct clinician supervision for treatment administration means that adherence/over‐adherence cannot be directly monitored (Jacobs et al, 2017; Komatsu et al, 2020; Moore, 2010).…”