Effects of a Phase III Cardiac Rehabilitation Program on Physical Status and Lipid Profiles in Elderly Patients With Coronary Artery Disease  Juntendo Cardiac Rehabilitation Program (J-CARP)

Seki, Eiichiro; Watanabe, Yoshirô; Shimada, Kazunori; Sunayama, Satoshi; Onishi, Tomo; Kawakami, Kyojiro; Sato, Mizue; Sato, Hiroyuki; Mikami, Hiroshi; Daida, Hiroyuki

doi:10.1253/circj.72.1230

Cited by 52 publications

(64 citation statements)

References 23 publications

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“…10 In addition, the CR group significantly improved muscle strength, flexibility and HRQOL scores calculated by SF-36. 9,10 These direct and indirect effects may have lead to the reduction in cardiovascular events in the subjects of this study.…”

Section: Cardiac Rehabilitation In Elderly Cad Patientsmentioning

confidence: 89%

“…Indeed, we have already demonstrated in a study of randomized design that CR reduced fat weight without a reduction in lean body weight, as well as the levels of TC in older patients with CAD. 10 The CR group maintained exercise capacity, although peak V…”

Section: Cardiac Rehabilitation In Elderly Cad Patientsmentioning

confidence: 93%

“…9, 10 We recruited 39 subjects in the J-CARP study; however, 1 patient dropped out and 1 patient was lost to follow-up, so finally, 37 patients were enrolled as the CR group in this study. As the Control group, we randomly screened 120 stable CAD patients, using medical records, who were outpatients during the same period of the CR program.…”

Section: Subjectsmentioning

confidence: 99%

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Effects of Phase III Cardiac Rehabilitation on Mortality and Cardiovascular Events in Elderly Patients With Stable Coronary Artery Disease

Onishi

Shimada

Sato

et al. 2010

Circ J

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Section: Cardiac Rehabilitation In Elderly Cad Patientsmentioning

confidence: 89%

Section: Cardiac Rehabilitation In Elderly Cad Patientsmentioning

confidence: 93%

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Effects of Phase III Cardiac Rehabilitation on Mortality and Cardiovascular Events in Elderly Patients With Stable Coronary Artery Disease

Onishi

Shimada

Sato

et al. 2010

Circ J

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“…A supervised exercise training regimen was difficult to sustain for 24 months in their trial, as more than half of the participants dropped out during that period. In the outpatient cardiac rehabilitation program by Seki and co-workers, total cholesterol, HDL-cholesterol, and apolipoprotein A-1 all decreased significantly in elderly patients with normocholesterolemic CAD 66) . This alone demonstrates the significant decrease in HDL-cholesterol levels brought about by therapeutic lifestyle changes, such as exercise, dietary instruction, risk factor education, and individual counseling.…”

Section: Physical Activity and Blood Lipid Levelsmentioning

confidence: 92%

“…A search for Japanese and English-language articles on RCTs investigating the effects of aerobic exercise, exercise training, exercise-based lifestyle intervention, and/or cardiac rehabilitation on lipid levels and on CVD outcomes turned up only 10 RCTs on Japanese subjects [57][58][59][60][61][62][63][64][65][66] . Three of these RCTs were excluded, however, as their lifestyle intervention programs [57][58][59] were based on multiple interventions rather than exercise.…”

Section: Physical Activity and Blood Lipid Levelsmentioning

confidence: 99%

Physical Activity in the Japan Population: Association with Blood Lipid Levels and Effects in Reducing Cardiovascular and All-Cause Mortality

Koba

Tanaka

Maruyama

et al. 2011

JAT

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According to many prospective cohort studies and meta-analyses of those studies, physical inactivity and/or low levels of physical fitness are associated with an elevated risk for the development of metabolic syndrome, type 2 diabetes, hypertension, coronary artery disease (CAD), and stroke, and with an increased risk of cardiovascular disease (CVD) mortality and all-cause mortality. Most of these analyses, however, were conducted on non-Japanese populations in the West. This report summarizes prospective observational and clinical studies in Japan. The annual national nutrition survey has shown a gradual decline in the number of walking steps in both genders and in all age groups over the last 10 years. While exercise habits have been gradually increasing in the elderly, only one-fifth of young and middle-aged people undertake leisure-time physical activity. Prospective cohort studies have shown that increased physical fitness and greater physical activity in either daily life or leisure time are of benefit in preventing all-cause mortality and CVD mortality. The daily number of walking steps is positively associated with HDL cholesterol levels and negatively associated with triglyceride levels. According to a random-effects model meta-analysis of 4 randomized controlled trials comparing supervised aerobic exercise training with non-exercise control in subjects without CAD, exercise resulted in a significant increase in HDL-cholesterol (10.01 mg/dL, 95% CI 5.38 to 14.65, p 0.0001). While this confirms the importance of physical activity in preventing CVD mortality and all-cause mortality, the levels of physical activity are on a declining trend in Japan, particularly among the young.

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Exercise-based cardiac rehabilitation for coronary heart disease

Heran

Chen²,

Ebrahim³

et al. 2011

Cochrane Database of Systematic Reviews

1,089

734

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Background The burden of coronary heart disease (CHD) worldwide is one of great concern to patients and healthcare agencies alike. Exercise-based cardiac rehabilitation aims to restore patients with heart disease to health. Objectives To determine the effectiveness of exercise-based cardiac rehabilitation (exercise training alone or in combination with psychosocial or educational interventions) on mortality, morbidity and health-related quality of life of patients with CHD. Search methods RCTs have been identified by searching CENTRAL, HTA, and DARE (using The Cochrane Library Issue 4, 2009), as well as MEDLINE (1950 to December 2009), EMBASE (1980 to December 2009), CINAHL (1982 to December 2009), and Science Citation Index Expanded (1900 to December 2009). Selection criteria Men and women of all ages who have had myocardial infarction (MI), coronary artery bypass graft (CABG) or percutaneous transluminal coronary angioplasty (PTCA), or who have angina pectoris or coronary artery disease defined by angiography. Data collection and analysis Studies were selected and data extracted independently by two reviewers. Authors were contacted where possible to obtain missing information. Main results This systematic review has allowed analysis of 47 studies randomising 10,794 patients to exercise-based cardiac rehabilitation or usual care. In medium to longer term (i.e. 12 or more months follow-up) exercise-based cardiac rehabilitation reduced overall and cardiovascular mortality [RR 0.87 (95% CI 0.75, 0.99) and 0.74 (95% CI 0.63, 0.87), respectively], and hospital admissions [RR 0.69 (95% CI 0.51, 0.93)] in the shorter term (< 12 months follow-up) with no evidence of heterogeneity of effect across trials. Cardiac rehabilitation did not reduce the risk of total MI, CABG or PTCA. Given both the heterogeneity in outcome measures and methods of reporting findings, a meta-analysis was not undertaken for health-related quality of life. In seven out of 10 trials reporting health-related quality of life using validated measures was there evidence of a significantly higher level of quality of life with exercise-based cardiac rehabilitation than usual care. Authors’ conclusions Exercise-based cardiac rehabilitation is effective in reducing total and cardiovascular mortality (in medium to longer term studies) and hospital admissions (in shorter term studies) but not total MI or revascularisation (CABG or PTCA). Despite inclusion of more recent trials, the population studied in this review is still predominantly male, middle aged and low risk. Therefore, well-designed, and adequately reported RCTs in groups of CHD patients more representative of usual clinical practice are still needed. These trials should include validated health-related quality of life outcome measures, need to explicitly report clinical events including hospital admission, and assess costs and cost-effectiveness.

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Effects of a Phase III Cardiac Rehabilitation Program on Physical Status and Lipid Profiles in Elderly Patients With Coronary Artery Disease Juntendo Cardiac Rehabilitation Program (J-CARP)

Cited by 52 publications

References 23 publications

Effects of Phase III Cardiac Rehabilitation on Mortality and Cardiovascular Events in Elderly Patients With Stable Coronary Artery Disease

Effects of Phase III Cardiac Rehabilitation on Mortality and Cardiovascular Events in Elderly Patients With Stable Coronary Artery Disease

Physical Activity in the Japan Population: Association with Blood Lipid Levels and Effects in Reducing Cardiovascular and All-Cause Mortality

Exercise-based cardiac rehabilitation for coronary heart disease

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