Effects of a Prolonged 3-Hour Sleep-Wake Cycle on Sleep Stages, Plasma Cortisol, Growth Hormone and Body Temperature in Man*

Weitzman, Elliot D.; Nogeire, Christopher; Perlow, Mark J.; Fukushima, David K.; Sassin, Jon F.; McGregor, Peter A.; Hellman, Louis M.

doi:10.1210/jcem-38-6-1018

Cited by 220 publications

(66 citation statements)

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“…Aging is also associated with increased cortisol response and more decreases in delta sleep in response to mild laboratory stressors (Prinz et al, 2000). Several studies in which subjects were forced to sleep in the second half of the night when HPA activity is enhanced have shown that delta sleep emerges only during troughs of cortisol activity (Follenius et al, 1992;Orth et al, 1967;Spath-Schwalbe et al, 1992Van Cauter et al, 1991;Weibel et al, 1995;Weitzman et al, 1974Weitzman et al, , 1983. In the most sophisticated set of studies of peripheral cortisol and delta sleep to date, Gronfier and colleagues calculated secretory rates of cortisol measured every 10 min using a deconvolutional procedure.…”

Section: Discussionmentioning

confidence: 99%

Delta Sleep Response to Metyrapone in Post-Traumatic Stress Disorder

Neylan

Lenoci

Maglione

et al. 2003

Neuropsychopharmacol

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Metyrapone blocks cortisol synthesis, which results in the stimulation of hypothalamic cortiocotropin-releasing factor (CRF) and a reduction in delta sleep. We examined the effect of metyrapone administration on endocrine and sleep measures in male subjects with and without chronic PTSD. We hypothesized that metyrapone would result in a decrease in delta sleep and that the magnitude of this decrease would be correlated with the endocrine response. Finally, we utilized the delta sleep response to metyrapone as an indirect measure of hypothalamic CRF activity and hypothesized that PTSD subjects would have decreased delta sleep at baseline and a greater decrease in delta sleep induced by metyrapone. Three nights of polysomnography were obtained in 24 male subjects with combatrelated PTSD and 18 male combat-exposed normal controls. On day 3, metyrapone was administered during normal waking hours until habitual sleep onset preceding night 3. Endocrine responses to metyrapone were measured in plasma obtained the morning following sleep recordings, the day before and after administration. Repeated measures ANOVAs were conducted to compare the endocrine and sleep response to metyrapone in PTSD and controls. PTSD subjects had significantly less delta sleep as indexed by stages 3 and 4, and total delta integrated amplitude prior to metyrapone administration. There were no differences in premetyrapone cortisol or ACTH levels in PTSD vs controls. PTSD subjects had a significantly decreased ACTH response to metyrapone compared to controls. Metyrapone caused an increase in awakenings and a marked decrease in quantitative measures of delta sleep that was significantly greater in controls compared to PTSD. The decline in delta sleep was significantly associated with the magnitude of increase in both 11-deoxycortisol and ACTH. The results suggest that the delta sleep response to metyrapone is a measure of the brain response to increases in hypothalamic CRF. These data also suggest that the ACTH and sleep EEG response to hypothalamic CRF is decreased in PTSD.

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Section: Discussionmentioning

confidence: 99%

Delta Sleep Response to Metyrapone in Post-Traumatic Stress Disorder

Neylan

Lenoci

Maglione

et al. 2003

Neuropsychopharmacol

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“…Laboratory studies on ultrashrct sleep include "short day" experiments and disrupted sleep studies (10,13,14,49,52,55,60,89). An early short day study was conducted by Weitzman, et.…”

Section: Ultrashort Sleep Studiesmentioning

confidence: 99%

Napping and Human Functioning during Prolonged Work

Naitoh¹,

Angus²

1987

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“…Hormones such as cortisol and melatonin are more strongly influenced by the endogenous circadian pacemaker, and are thus typically misaligned in workers with atypical work schedules. Cortisol levels reach their minimal values early in the night and their maximum values around the regular time of awakening [58][59][60][61] . Melatonin also exhibits a robust and significant circadian variation [62][63][64] .…”

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confidence: 99%

Light Treatment and Circadian Adaptation to Shift Work

Boivin

James

2005

Ind Health

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Work at unconventional hours can have both long and short term consequences. Shift workers are often required to perform their duties at times that are not favoured by the body's endogenous clock, or circadian pacemaker. A typical night shift worker, for example, may report reductions in alertness and performance during shifts, or significant difficulty attaining sleep of recuperative value in the day, all the while being more likely to develop health complications. The study of circadian physiology has significantly contributed to our current ability to aid the shift worker deal with atypical schedules. We discuss the usefulness of light treatment as a countermeasure for maladaptation to atypical work schedules.

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Effects of a Prolonged 3-Hour Sleep-Wake Cycle on Sleep Stages, Plasma Cortisol, Growth Hormone and Body Temperature in Man*

Cited by 220 publications

References 0 publications

Delta Sleep Response to Metyrapone in Post-Traumatic Stress Disorder

Delta Sleep Response to Metyrapone in Post-Traumatic Stress Disorder

Napping and Human Functioning during Prolonged Work

Light Treatment and Circadian Adaptation to Shift Work

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