Effects of a Proprietary Freeze‐Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well‐Being in Men: A Randomized, Double‐Blind, Placebo‐Controlled Study

Abstract

Background. Physta is a proprietary product containing a freeze-dried water extract of Eurycoma longifolia (tongkat ali), which is traditionally used as an energy enhancer and aphrodisiac. We aim to evaluate a 300 mg combination of Physta and Polygonum minus, an antioxidant, with regard to sexual performance and well-being in men. Methods. Men that aged 40–65 years were screened for this 12-week randomized, double-blind, placebo-controlled, parallel-group study. Outcome measures included validated questionnaires that aimed to evaluate erectile function, satisfaction with intervention, sexual intercourse performance, erectile hardness, mood, and overall quality of life. Results. 12 subjects in the active group and 14 in the placebo group completed the study. Significant improvements were noted in scores for the Sexual Intercourse Attempt diary, Erection Hardness Scale, Sexual Health Inventory of Men, and Aging Male Symptom scale (P < 0.05 for all). Three adverse events were reported in the active group and four in the placebo group, none of which were attributed to study product. Laboratory evaluations, including liver and kidney function testing, showed no clinically significant abnormality. Conclusion. Supplementation for twelve weeks with Polygonum minus and the proprietary Eurycoma longifolia extract, Physta, was well tolerated and more effective than placebo in enhancing sexual performance in healthy volunteers.

Phytoandrogenic properties ofEurycoma longifoliaas natural alternative to testosterone replacement therapy

“…In another placebo‐controlled trial, when 200 mg day −1 of aqueous TA extract was administered for 3 months to a population of 26 men with mild ED, the Ageing Male Score (AMS) score was significantly reduced in the treatment group (Udani et al ., ). Similarly, Tambi et al .…”

“…In another study, the same standardised aqueous extract of TA (Physta ® ) was administered to mildly erectile dysfunctional men in a randomised, placebo‐controlled trial of 26 subjects (Udani et al ., ), where significant improvements in several parameters were observed at the end of trial by week 12; Erection Hardness Scale ( P = 0.012), Sexual Health Inventory for Males ( P = 0.03) and Ageing Male Symptom Score ( P = 0.047). As being one of symptoms of low testosterone levels and ageing males, ED, especially in older men, is closely related to testosterone deficiency (Köhler et al ., ; Yassin & Saad, ).…”

Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects

“…The patent discloses a process whereby Eurycoma longifolia roots undergo an aqueous extraction combined with HPLC and size-exclusion chromatography to yield a bioactive peptide fraction (a 4300 dalton glycopeptide with 36 amino acids) that is responsible for its effects in maintaining testosterone levels. The bioactive fraction of Eurycoma longifolia root delivers a demonstrated ability to improve testosterone levels [41], increase muscle size and strength [43,44], improve overall well-being [45,46], accelerate recovery from exercise [47] enhance weight loss [48,49], reduce stress [50], and reduce symptoms of fatigue [51-53]. …”

Phytochemical and biological research of Polygoneae medicinal resources

“…Supplementation for 12 weeks with P. minus and the proprietary Eurycoma longifolia extract, Physta, was well tolerated and more effective than placebo in enhancing sexual performance in healthy volunteers (Udani et al, 2014). P. cuspidatum inhibits pancreatic lipase activity and adipogenesis via attenuation of lipid accumulation , thus having antiobesity effect.…”