Effects of a prostacyclin analog iloprost on kidney function, renin-angiotensin and kallikrein-kinin systems, prostanoids and catecholamines in man

Effects of prostacyclin on renal haemodynamics, renal tubular function and vasoactive hormones in healthy humans. A placebo‐controlled dose–response study

“…In accordance with several other human studies we found study of healthy control subjects we did not measure any changes in renal sodium, lithium and water excretion during a decrease in blood pressure and an increase in heart rate during PGI 2 infusion [4][5][6][7][8] indicating that prostacyclin is a PGI 2 infusion. This does not exclude a direct effect of PGI 2 on renal tubular sodium and water handling, since two of potent systemic vasodilator.…”

“…According to some studies, PGI 2 had no combination of both. Surprisingly, renin was not increased in some of the previous studies [6,7,9]. The reason for this effect on renal sodium and water excretion [5,7,8] small in regards to sodium excretion [24].…”

“…Also, to our knowledge no information exists about the interaction between PGI 2 on the one hand affect the vascular bed, while others have their main effects on the renal tubular handling of sodium and water [1][2][3].The and renal haemodynamics, vasoactive and sodium and water regulating hormones on the other hand in healthy control prostaglandin analogue prostacyclin (PGI 2 ) has been shown to affect both renal and systemic haemodynamics in humans subjects. Therefore we have investigated the acute effect of [4][5][6][7], although the information is ambiguous regarding the effect on renal tubular handling of sodium and water. In intravenous prostacyclin on 1) renal haemodynamics, 2) renal tubular function, 3) plasma concentration of some studies no effect has been reported [5,7,8] whereas an increase in sodium excretion has been reported in others angiotensin II (Ang II), aldosterone (Aldo), atrial natriuretic peptide (ANP) and arginine vasopressin (AVP), and 4) mean [6,9].…”

“…Therefore we have investigated the acute effect of [4][5][6][7], although the information is ambiguous regarding the effect on renal tubular handling of sodium and water. In intravenous prostacyclin on 1) renal haemodynamics, 2) renal tubular function, 3) plasma concentration of some studies no effect has been reported [5,7,8] whereas an increase in sodium excretion has been reported in others angiotensin II (Ang II), aldosterone (Aldo), atrial natriuretic peptide (ANP) and arginine vasopressin (AVP), and 4) mean [6,9]. Furthermore, no simultaneous measurements are arterial blood pressure (MBP) and heart rate (HR) in a randomized placebo controlled dose-response study in extracted from plasma by means of Sep-pak C-18 cartridges.…”

Antagonists of embryo-derived platelet-activating factor prevent implantation of mouse embryos

“…At the cellular level PAF induces activation of platelets (Snyder, 1985) and leucocytes (O'Flaherty et al, 1981) as well as aortic smooth muscle and renal epithelial cells (Kawaguchi & Yasuda, 1986) through its stimulation of phospholipase C leading to the breakdown of phosphatidylinositol, the formation of phosphatidic acid (Berridge et al, 1984) (Ylitalo et al, 1984) and urinary excretion (Ylitalo et al, 1985). At the cellular level iloprost stimulates adenyl cyclase activity leading to increased cAMP levels and a reduction in cytoplasmic calcium (Kaser-Glanzmann et al, 1977).…”