Effects of a Protein-Free Diet on the Rat Stomach

Sumiyoshi, Hiromichi; Kanezawa, Atsushi; Yasui, Wataru; Tahara, Eiichi

doi:10.1016/0016-5085(87)90982-6

Cited by 4 publications

(1 citation statement)

References 45 publications

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“…Tetragastrin significantly reduced the incidence of MNNG-induced gastric cancers (76), with unchanged (77) or undifferentiated (78) resultant cancers. Pentagastrin increased the growth of transplanted gastric cancer in nude mice (79) but not if the transplanted cancer was a mucinous adenocarcinoma (80). Pentagastrin also stimulated the growth of adenocarcinoma cells in vitro (81).…”

Section: Estrupolrrtion From Animal Studiesmentioning

confidence: 97%

Risks of Therapeutic Achlorhydria

Wormsley

1988

Scandinavian Journal of Gastroenterology

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Wormsley KG. Risks of therapeutic achlorhydria. Scand J Gastroenterol 1988, An analysis has been made of the potential risks involved in the clinical use of the new, powerful gastric secretory inhibitors. These drugs are undoubted carcinogens in animals, although the mechanism underlying the carcinogenic effect has not yet been defined. Prediction of potential human risk depends on whether the results of carcinogenic studies in animals are considered relevant to man. If animal studies are not suitable for extrapolation to man, a lot of time, money, and effort have been wasted, and human beings will have to be (and, regrettably, are being) used as experimental subjects. If the results of the animal studies predict foreseeable human disease, the drugs must not be used, except in the treatment of gastrinomas, since the benefits of use are negligible, while the consequences of releasing a flood of potential gastric carcinogens are intolerable.Scand J Gastroenterol Downloaded from informahealthcare.com by University of British Columbia on 11/18/14For personal use only.Scand J Gastroenterol Downloaded from informahealthcare.com by University of British Columbia on 11/18/14For personal use only.

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Section: Estrupolrrtion From Animal Studiesmentioning

confidence: 97%

Risks of Therapeutic Achlorhydria

Wormsley

1988

Scandinavian Journal of Gastroenterology

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Helicobacter pylori and gastric cancer

Nomura

Stemmermann

1993

J of Gastro and Hepatol

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This review focuses on the similarities between the epidemiology of gastric cancer and the epidemiology of Helicobacter pylori. Their demographic patterns and the results of studies regarding familial and environmental risk factors are described. The association of gastric cancer and H. pylori infection with both gastric ulcer and chronic atrophic gastritis is also characterized and the possibility that a H. pylori infection could lead to gastric cancer is discussed.

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THE EFFECTS OF RANITIDINE and CYSTEAMINE ON INTESTINAL METAPLASIA INDUCED BY X‐IRRADIATION IN RATS

Watanabe¹,

Kamikawa²,

Nakagawa³

et al. 1988

Acta Pathologica Japonica

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The influence of ranitidine and cysteamlne on intestinal metaplasia was examined in 7‐month‐old male Crj: CD (SD) rats. At the age of 5 weeks, the animals were treated with 10 Gy doses of X‐rays at 3‐day intervals up to a total of 20 Gy in the gastric region, and 6 months after irradiation, the rats received either ranitidine (0.02% in diet) or cysteamine (0.1% in drinking water) for 2 months. The incidence and number of intestinal metaplasia with alkaline phosphatase‐positive foci in rats given X‐rays and cysteamlne (group 4) were significantly low compared with those in rats given X‐rays and ranitidine (group 3) (p<0.01). In both the pyloric and the fundic gland mucosae, the average numbers of type C metaplasia (intestinal crypts with Paneth cells) and total numbers of metaplastic foci in rats of group 3 were much higher than those in group 4 (P<0.05). The present results showed that the occurrence of intestinal metaplasia was significantly increased after administration of ranitidine and decreased by cysteamine. ACTA PATHOL JPN 38 : 1285‐1296, 1988.

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Effects of a Protein-Free Diet on the Rat Stomach

Cited by 4 publications

References 45 publications

Risks of Therapeutic Achlorhydria

Risks of Therapeutic Achlorhydria

Helicobacter pylori and gastric cancer

THE EFFECTS OF RANITIDINE and CYSTEAMINE ON INTESTINAL METAPLASIA INDUCED BY X‐IRRADIATION IN RATS

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