Effects of a pyranocoumarin compound isolated from a Chinese medicinal plant on ischemic myocardial dysfunction in anesthetized dogs

Chang, Tian-hui; Adachi, Hideyuki; Mori, Nobuhito; Saito, Isao; Okuyama, Toru

doi:10.1016/0014-2999(94)90059-0

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…Khellactone (dihydroseselin) coumarins possess various activities, including calcium blocker and antiplatelet aggregation [ 62 , 63 ]. Khellactone coumarins with 3′S, 4′S configuration (praeruptorins A, B, C, and D) were first isolated from dried roots of P. praeruptorum ( Peucedani radix) which is commonly used in Traditional Chinese Medicine (TCM) for treatment of cough and upper respiratory infections and as an antipyretic, antitussive, and mucolytic agent.…”

Section: Discussionmentioning

confidence: 99%

The Vasodilatory Effects of Anti‐Inflammatory Herb Medications: A Comparison Study of Four Botanical Extracts

Zhang

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Inflammation plays a pivotal role in the development and progression of cardiovascular diseases, in which, the endothelium dysfunction has been a key element. The current study was designed to explore the vasodilatory effect of anti-inflammatory herbs which have been traditionally used in different clinical applications. The total saponins from Actinidia arguta radix (SAA), total flavonoids from Glycyrrhizae radix et rhizoma (FGR), total coumarins from Peucedani radix (CPR), and total flavonoids from Spatholobi caulis (FSC) were extracted. The isometric measurement of vasoactivity was used to observe the effects of herbal elements on the isolated aortic rings with or without endothelium. To understand endothelium-independent vasodilation, the effects of herb elements on agonists-induced vasocontractility and on the contraction of endothelium-free aortic rings exposed to a Ca2+-free medium were examined. Furthermore, the role of nitric oxide signaling in endothelium-dependent vasodilation was also evaluated. In summary, FGR and FSC exhibit potent anti-inflammatory effects compared to CPR and SAA. FGR exerts the strongest vasodilatory effect, while CPR shows the least. The relaxation induced by SAA and FSC required intact endothelia. The mechanism of this vasodilation might involve eNOS. CPR-mediated vasorelaxation appears to involve interference with intracellular calcium homeostasis, blocking Ca2+ influx or releasing intracellular Ca2+.

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Section: Discussionmentioning

confidence: 99%

The Vasodilatory Effects of Anti‐Inflammatory Herb Medications: A Comparison Study of Four Botanical Extracts

Zhang

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…On ischemic myocardial dysfunction in anesthetized dogs, injection of Pd-la (0.1–3.0 mg/kg i.v. ) considerably and dose dependently improved coronary blood flow, reduced mean aortic pressure, and systemic vascular resistance with a minor rise in heart rate[ 9 ]. Furthermore, myocardial function was improved on regional myocardial dysfunction in anesthetized open-chest dogs by infusion of 0.15 mg/kg/min Pd-la for 30 minutes [ 24 ].…”

Section: Pharmacological and Toxicological Aspectsmentioning

confidence: 99%

“…Khellactone (dihydroseselin) coumarins are notable because of their different activities, including calcium antagonist activity [ 9 ], antiplatelet aggregation [ 10 ], P-glycoprotein (Pgp) inhibitory ability [ 11 ], and anti-HIV effect [ 12 ]. For the first time, khellactone coumarins with 3′S, 4′S configuration (praeruptorins A, B, C, and D) are reported from dried roots of P .…”

Section: Introductionmentioning

confidence: 99%

“…In the Chinese Pharmacopeia, praeruptorin A and praeruptorin B are listed as the chemical markers for evaluating the quality of Peucedani Radix and related products [ 21 ]. Praeruptorins were found to be responsible for various pharmacological properties such as calcium antagonist activity [ 9 ], anti-inflammatory action [ 22 ], antiasthma, vasorelaxant and antiallergic effects [ 23 , 24 ], cardiac protective [ 25 , 26 ], hepatoprotective [ 27 ], antitumor [ 28 – 30 ], and antiplatelet aggregation activities [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Biological Activities and Pharmacokinetics of Praeruptorins fromPeucedanumSpecies: A Systematic Review

Sarkhail

Shafiee

Sarkheil

2013

BioMed Research International

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Praeruptorins belonging to the angular-type pyranocoumarins are bioactive constituents that have been isolated from some Peucedanum species such as P. praeruptorum, which is used in traditional Chinese medicine for treatment of cold, cough, upper respiratory infections, and so forth. Many reports have demonstrated that the beneficial pharmacological effects of P. praeruptorum root on cardiovascular, pulmonary, immune, and nervous system diseases were attributed to the presence of praeruptorins. The aim of this review is to explain the recent efforts of scientists in pharmacological screening of natural and synthetic praeruptorin derivatives, studying the mechanisms of some praeruptorins action, pharmacokinetics, toxicity, and relevant structure-activity relationships. Based on reported data about the pharmacological properties of praeruptorins and semisynthetic derivatives of them, it is hopeful that in the near future more studies focus on the discovery of the new application and therapeutic uses of these bioactive compounds and understanding the specific mechanisms of them. The present discusses the reports on molecular and biological activities of praeruptorins of the genus Peucedanum, from 1976 onwards.

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“…It is a novel Ca 2+ influx blocker (Kozawa et al, 1981) and K + channel opener (Chang et al, 1994). It shows that Pd-Ia could inhibit the expression of apoptosis-related proteins, reduce the level of proinflammatory factors, and improve intermediate filament desmin and vimentin content in ischemia-reperfusion myocardiocytes (Chang et al, 2002;Wang et al, 2004;Chang et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation ofdl-praeruptorin A microemulsion based hydrogel for dermal delivery

Zhang

Hong

et al. 2014

Drug Delivery

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(2015) Preparation and evaluation of dl-praeruptorin A microemulsion based hydrogel for dermal delivery, Drug Delivery, 22:6, 757-764, DOI: 10.3109/10717544.2014 AbstractThe purpose of the present investigation was to develop and optimize the microemulsion (ME) as a transdermal system for Pd-Ia, a poor water soluble and low bioavailable drug. The pseudoternary phase diagrams were constructed for various ME formulations including oleic acid as the oil phase, Cremophor RH40 as the surfactant, ethanol as the cosurfactant, and water. The maximum cumulative amount permeated through rat abdominal skins per unit area in 32 h (Q 32 ), and the maximum flux were evaluated using the Franz diffusion cell in order to optimize the ME formulation. The results indicated that the optimized ME formulation was composed of oleic acid (5%, W/W), Cremophor RH40 ( , the maximum flux was 11.467 ± 0.500 mg cm À2 h À1. ME-gel was administered transdermally to rats. The mean plasma concentration of Pd-Ia following transdermal application of ME-gel could be maintained for 32 h at least and the half-life was evidently prolonged. It shows that the ME-gel could be a promising vehicle for dermal delivery of Pd-Ia.

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Effects of a pyranocoumarin compound isolated from a Chinese medicinal plant on ischemic myocardial dysfunction in anesthetized dogs

Cited by 9 publications

References 14 publications

The Vasodilatory Effects of Anti‐Inflammatory Herb Medications: A Comparison Study of Four Botanical Extracts

The Vasodilatory Effects of Anti‐Inflammatory Herb Medications: A Comparison Study of Four Botanical Extracts

Biological Activities and Pharmacokinetics of Praeruptorins fromPeucedanumSpecies: A Systematic Review

Preparation and evaluation ofdl-praeruptorin A microemulsion based hydrogel for dermal delivery

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