Effects of a selective glucocorticoid receptor agonist on experimental keratoplasty

Abstract

Our results indicate that topical application of a SEGRA compound significantly prolongs corneal graft survival in an experimental keratoplasty model. It further suggests that SEGRA can be a potentially useful drug to suppress the immune response.

Modern Aspects of Glaucoma Pathogenesis Local Factors for Development of Primary Open-Angle Glaucoma Associated with Impairment of Secretory Functions of the Eye Membranes

“…The application of glucocorticosteroids brought forth more efficient engraftment. Moreover, the terms of engraftment correlated with the low expression of cytokines, especially IL-I [Pleyer U. et al, 2005].…”

“…At present, aspects related to studies on "endocrine homeostasis" in post-barrier membrane of an eye at both norm and pathology are the subject of a wide discussion in ophthalmology. The available publications are not numerous; furthermore, they are of a rather statement-ofthe-fact character [Southren A. et al, 1976;Floman N., Zor U., 1977;Kasavina B. et al, 1977;Weinstein B. et al, 1983;Stone R., Wilson C., 1984;Stojek A. et al, 1991;Chiquet C., Denis P., 2004;Burch J. et al, 2005;Pleyer U. et al, 2005;Schwartz B. et al, 2005;Vessey K. et al, 2005]. In particular, there are reports discussing the possibility of cortisol local synthesis in eye membranes.…”

Update on Immunosuppressive Therapy for Corneal Transplantation

“…Topical application of selective glucocorticoid receptor agonists was found to significantly prolong corneal graft survival in an experimental keratoplasty model suggesting that it can be a potentially useful drug to suppress the immune response. 44 Monoclonal antibodies and other biologics are not used routinely in corneal transplantation, but may be useful for both prophylaxis and for rescue after graft rejection. 30,45 CAMPATH-1H, a monoclonal antibody that rapidly induces lymphopenia after IV infusion, has been shown to be effective in rescuing corneal grafts undergoing acute rejection.…”