Effects of a selective serotonin reuptake inhibitor on urine spraying behavior in cats

Pryor, Patricia; Hart, Benjamin L.; Cliff, Kelly D.; Bain, Melissa

doi:10.2460/javma.2001.219.1557

Cited by 72 publications

(56 citation statements)

References 12 publications

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“…A notable caveat for this analysis is the lack of studies with a placebo control group. In an attempt to remedy this we used the information from two studies with a placebo group [6,18] to generate an estimate of the effect size of the placebo. This effect size was then used in an analysis of all studies in order to compare interventions.…”

Section: Discussionmentioning

confidence: 99%

“…The definition of a successful treatment outcome varied between studies and included, the number of cats that ceased or reduced spraying by 90% [18,21] or the number of cats that ceased [2,6].…”

Section: Study Selectionmentioning

confidence: 99%

“…The number of cats living within each multi-cat household varied, for example, Frank et al [2] reported a range of 2-14 cats per household with a mean of 4.5 and a median of 3. A proportion of studies only recruited cats from multi-cat households with # 4 cats [18,21,33].…”

Section: Types Of Participantsmentioning

confidence: 99%

“…Current strategies advocate cleaning regimes for the urine and behavioural modification to remove any specific triggers alongside specific psychopharmacological and non-pharmacological interventions such as use of the feline facial pheromone fraction in the environment [14]. Suggested psychopharmacological treatments include benzodiazepines, azapirones, tricyclic antidepressants and selective serotonin reuptake inhibitors [1,15,16,17,18,19].…”

Section: Introductionmentioning

confidence: 99%

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The effect of presenting forage in multi-layered haynets and at multiple sites on night time budgets of stabled horses

Ellis¹,

Redgate

Zinchenko

et al. 2015

Applied Animal Behaviour Science

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Feline urine spraying inside the home is a common problem behaviour that owners seek advice for from veterinarians. Individual trials relating to a variety of interventions produce variable results, and to date, no consensus on the value of different treatments has emerged. This study therefore aimed to meta-analyse, current data from appropriate published clinical trials that evaluate treatments for feline urine spraying. Inclusion and exclusion criteria for study selection were predefined and methodological quality was assessed by two independent reviewers. Ten studies in nine publications that either evaluated pharmacotherapy or pheromonatherapy (the use of a synthetic analogue of the F3 facial fraction in the cat) were suitable for analysis. There was a significant (P,0.001) association between the use of any intervention and the number of cats that ceased or reduced urine spraying by at least 90%. Analysis by intervention type indicated that fluoxetine, clomipramine and pheromonatherapy may each assist in managing urine spraying beyond a placebo based intervention. This is the first time meta-analytical techniques have been used and reported to evaluate the efficacy of interventions used in veterinary behavioural medicine, and it has established confidence in the value of both conventional treatments (pharmacotherapy) and a more recently developed treatment modality (pheromonatherapy) as an adjunct to the management of this problem. It is suggested that future research into treatment efficacy for this problem uses the benchmark standard of randomised, controlled trials lasting for at least 8 weeks, with the outcome criteria of cessation of feline urine spraying or reduction by at least 90%.

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Section: Discussionmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Section: Types Of Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of presenting forage in multi-layered haynets and at multiple sites on night time budgets of stabled horses

Ellis¹,

Redgate

Zinchenko

et al. 2015

Applied Animal Behaviour Science

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show abstract

“…Fluoxetine, buspirone, clomipramine and paroxetine are often used as an initial treatment choice. 26,40,[49][50][51][52] If you are uncertain which agent to use, additional reading or consultation with a veterinary behaviorist will facilitate your selection.…”

Section: Separation Of Social Groupsmentioning

confidence: 99%

AAFP and ISFM Guidelines for Diagnosing and Solving House-Soiling Behavior in Cats

Carney¹,

Sadek²,

Curtis

et al. 2014

Journal of Feline Medicine and Surgery

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Rationale: These Guidelines have been developed by the American Association of FelinePractitioners (AAFP) and the International Society of Feline Medicine (ISFM) as a resource for veterinary practitioners who want to better understand and manage the important clinical condition of house-soiling in their feline patients. The Guidelines offer straightforward, practical solutions that, in most cases, will help veterinarians and cat owners prevent, manage or entirely remediate feline house-soiling behavior. Evidence base: The Guidelines include scientifically documented information when it is available. However, because research is often lacking, some recommendations reflect the accumulated clinical experience of the authors. PURPOSE OF THE GUIDELINESWe often hear the statistics: house-soiling is one of the most common feline behavior problems reported by cat owners and a major reason why owners relinquish cats to animal shelters.1 According to the National Council on Pet Population Study and Policy, shelters in the US euthanize 72% of relinquished cats, 2 many because of house-soiling behavior. If 4-9 million cats are euthanized every year, this could be more than 10,000 cats each day. Veterinarians can decrease this number by helping to correct this commonplace problem. With this goal in mind, we have developed the AAFP and ISFM Guidelines for Diagnosing and Solving House-Soiling Behavior in Cats (hereafter referred to as the Guidelines).The Guidelines provide clinicians with basic tools for educating cat owners about the prevention of house-soiling behavior. The Guidelines also apply the principles of the previously published AAFP and ISFM Feline Environmental Needs Guidelines, 3 which describe the physical setting where a cat can thrive. Importantly, these current Guidelines elaborate on elimination behavior, describe and illustrate the cat's ideal litter box (also known as a litter tray), and discuss how it should be managed. While prevention of house-soiling is ideal, practitioners see many cats with pre-existing house-soiling behavior. The Guidelines explain that, even though the pathophysiology and behavioral etiology of house-soiling is often multifactorial, a thorough chronological history and a systematic diagnostic approach to this problem can be the key to developing an effective treatment plan. CONTENTSThe Guidelines offer straightforward, practical solutions for practitioners and cat owners to implement, but are not intended to be a comprehensive treatise on feline behavior. The Guidelines' authors recognize that feline house-soiling can be a complex problem. Although many cases are straightforward, individual cases can be challenging, sometimes frustrating, and occasionally beyond the expertise or experience of the general, primary care practitioner. In cases where an acceptable response does not occur within a timeframe mutually agreed upon by the veterinarian and client, consultation with a qualified behaviorist or internist is advisable.In most cases, the Guidelines will help veterinarians and cat...

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Selective Serotonin Reuptake Inhibitors

2005

Veterinary Psychopharmacology

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Effects of a selective serotonin reuptake inhibitor on urine spraying behavior in cats

Abstract: Administration of fluoxetine hydrochloride for treatment of urine spraying in cats can be expected to considerably reduce the rate of urine marking. The frequency of spraying before treatment is predictive of the spraying rate when the drug is discontinued.

Cited by 72 publications

References 12 publications

The effect of presenting forage in multi-layered haynets and at multiple sites on night time budgets of stabled horses

The effect of presenting forage in multi-layered haynets and at multiple sites on night time budgets of stabled horses

AAFP and ISFM Guidelines for Diagnosing and Solving House-Soiling Behavior in Cats

Selective Serotonin Reuptake Inhibitors

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