Effects of a short-course of amoxicillin/clavulanic acid on systemic and mucosal immunity in healthy adult humans

Dufour, Vinciane; Millon, Laurence; Faucher, Jean‐François; Bard, Emmanuel; Robinet, Éric; Piarroux, Renaud; Vuitton, Dominique-Angèle; Meillet, D

doi:10.1016/j.intimp.2005.01.007

Cited by 31 publications

(25 citation statements)

References 38 publications

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“…However, amoxicillin/clavulanic acid is reported to inhibit the interferon-gamma (interferon-c) activity in human lung epithelia cell lines in vitro, 17 but no effect could be detected in an in vivo study in humans. 18 Thus, it might have suppressed endogenous interferon-c in the cats, which is reported to play an important role in the battle against the virus. 19 Potentially, it also might have decreased the effect of the FeIFN-v.…”

Section: Discussionmentioning

confidence: 99%

Effect of Feline Interferon‐Omega on the Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis

Ritz

Egberink

Hartmann

2007

Veterinary Internal Medicne

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Background: There is no therapy with proven efficacy to treat cats with feline infectious peritonitis (FIP). Hypothesis: Feline interferon‐omega (FeIFN‐ω) prolongs survival time and increases quality of life in cats with FIP. Animals: Thirty‐seven privately owned cats were subjects of this study. Methods: The study was performed as a placebo‐controlled double‐blind trial. Feline infectious peritonitis was confirmed by histology or immunostaining of feline coronavirus (FCoV) antigen in effusion or tissue macrophages or both. The cats were randomly selected for treatment with either FeIFN‐to or a placebo. All cats received adjunctive treatment with glucocorticoids and antibiotics and passive immunization with Feliserin. Results: There was no statistically significant difference in the survival time of cats treated with FeIFN‐ω versus placebo or in any other variable evaluated (with the exception of the lymphocyte count). The cats survived between 3 and 200 days (median, 9 days). There was only 1 long‐term survivor (>3 months), and the cat was in the FeIFN‐ω group. Conclusion and Clinical Relevance: No effect of FeIFN‐ω on survival time or quality of life could be demonstrated in this study.

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Section: Discussionmentioning

confidence: 99%

Effect of Feline Interferon‐Omega on the Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis

Ritz

Egberink

Hartmann

2007

Veterinary Internal Medicne

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“…A series of experiments in mice have shown that antibiotic treatment can reduce the capacity to fight infections by Gram-positive organisms by decreasing the expression of bactericidal compounds and diminishing neutrophil-mediated killing ( Brandl et al, 2008 ; Vaishnava et al, 2008 ; Clarke et al, 2010 ; Ubeda et al, 2010 ). In the case of the adaptive immune system, both the expression of Major Histocompatibility Complex genes in the small and large intestine and the levels of immunoglobulin G (IgG) in serum have been shown to decrease in reponse to amoxicillin-induced gut microbiota changes ( Dufour et al, 2005 ).…”

Section: Through What Mechanisms Do Gut Microbiota Alterations Affectmentioning

confidence: 99%

Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances

2016

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The human microbiome is overly exposed to antibiotics, due, not only to their medical use, but also to their utilization in farm animals and crops. Microbiome composition can be rapidly altered by exposure to antibiotics, with potential immediate effects on health, for instance through the selection of resistant opportunistic pathogens that can cause acute disease. Microbiome alterations induced by antibiotics can also indirectly affect health in the long-term. The mutualistic microbes in the human body interact with many physiological processes, and participate in the regulation of immune and metabolic homeostasis. Therefore, antibiotic exposure can alter many basic physiological equilibria, promoting long-term disease. In addition, excessive antibiotic use fosters bacterial resistance, and the overly exposed human microbiome has become a significant reservoir of resistance genes, contributing to the increasing difficulty in controlling bacterial infections. Here, the complex relationships between antibiotics and the human microbiome are reviewed, with focus on the intestinal microbiota, addressing (1) the effects of antibiotic use on the composition and function of the gut microbiota, (2) the impact of antibiotic-induced microbiota alterations on immunity, metabolism, and health, and (3) the role of the gut microbiota as a reservoir of antibiotic resistances.

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“…Intraperitoneal administration of the NOD1 ligand Mur N AcTri DAP to antibiotic-treated mice enhanced neutrophil killing capacity [21]. In another study, administration of amoxicillin/clavulanate diminished IgG serum levels in humans without affecting IgA or IgM levels [56]. …”

Section: Antibiotic-induced Changes In the Microbiota Impact Immunitymentioning

confidence: 99%

Antibiotics, microbiota, and immune defense

Úbeda¹,

Pamer

2012

Trends in Immunology

296

205

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The gastrointestinal tract microbiota contributes to the development and differentiation of the mammalian immune system. The composition of the microbiota affects immune responses and affects susceptibility to infection by intestinal pathogens and development of allergic and inflammatory bowel diseases. Antibiotic administration, while facilitating clearance of targeted infections, also perturbs commensal microbial communities and decreases host resistance to antibiotic-resistant microbes. Here, we review recent advances that begin to define the interactions between complex intestinal microbial populations and the mammalian immune system and how this relation is perturbed by antibiotic administration. We further discuss how antibiotic-induced disruption of the microbiota and immune homeostasis can lead to disease and we review strategies to restore immune defenses during antibiotic administration.

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Effects of a short-course of amoxicillin/clavulanic acid on systemic and mucosal immunity in healthy adult humans

Cited by 31 publications

References 38 publications

Effect of Feline Interferon‐Omega on the Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis

Effect of Feline Interferon‐Omega on the Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis

Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances

Antibiotics, microbiota, and immune defense

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