Effects of a single administration of captopril on hemodynamics and serum angiotensin converting enzyme activity, plasma renin activity and plasma aldosterone concentration in hypertensive patients.

Hashimoto, Haruhisa; Hiwada, Kunio; Kokubu, Tatsuo

doi:10.1253/jcj.45.176

Cited by 5 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Captopril is an angiotensin converting enzyme (ACE) inhibitor, which reduces BP [48-50]. Reports in literature show that acute captopril administration may decrease [51,52], decrease or have no effect [53] on HR, while chronic captopril administration may decrease [54] or increase HR [48]. The higher BP and HR readings observed with the tail-cuff measurements in the conscious rats earlier in the study, when compared to the values obtained in anaesthetized rats with the invasive BP measurement, may be partly due to sympathetic activation [29,55,56].…”

Section: Discussionmentioning

confidence: 99%

The contributions of muscarinic receptors and changes in plasma aldosterone levels to the anti-hypertensive effect of Tulbaghia violacea

Raji

Mugabo

Obikeze

2013

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundTulbaghia violacea Harv. (Alliaceae) is used to treat various ailments, including hypertension (HTN) in South Africa. This study aims to evaluate the contributions of muscarinic receptors and changes in plasma aldosterone levels to its anti-hypertensive effect.MethodsIn the acute experiments, methanol leaf extracts (MLE) of T. violacea (30–120 mg/kg), muscarine (0.16 -10 μg/kg), and atropine (0.02 - 20.48 mg/kg), and/or the vehicle (dimethylsulfoxide (DMSO) and normal saline (NS)) were respectively and randomly administered intravenously in a group of spontaneously hypertensive (SHR) weighing 300 to 350 g and aged less than 5 months. Subsequently, T. violacea (60 mg/kg) or muscarine (2.5 μg/kg) was infused into eight SHRs, 20 min after atropine (5.12 mg/kg) pre-treatment. In the chronic (21 days) experiments, the SHRs were randomly divided into three groups, and given the vehicle (0.2 ml/day of DMSO and NS), T. violacea (60 mg/kg/day) and captopril (10 mg/kg/day) respectively into the peritoneum, to investigate their effects on blood pressure (BP), heart rate (HR), and plasma aldosterone levels. Systolic BP and HR were measured using tail-cuff plethysmography during the intervention. BP and HR were measured via a pressure transducer connecting the femoral artery and the Powerlab at the end of each intervention in the acute experiment; and on day 22 in the chronic experiment.ResultsIn the acute experiments, T. violacea, muscarine, and atropine significantly (p < 0.05) reduced BP dose-dependently. T. violacea and muscarine produced dose-dependent decreases in HR, while the effect of atropine on HR varied. After atropine pre-treatment, dose-dependent increases in BP and HR were observed with T. violacea; while the BP and HR effects of muscarine were nullified. In the chronic experiments, the T. violacea-treated and captropril-treated groups had signicantly lower levels of aldosterone in plasma when compared to vehicle-treated group. Compared to the vehicle-treated group, significant reduction in BP was only seen in the captopril-treated group; while no difference in HR was observed among the groups.ConclusionThe results obtained in this study suggest that stimulation of the muscarinic receptors and a reduction in plasma aldosterone levels contribute to the anti-hypertesive effect of T. violacea.

show abstract

Section: Discussionmentioning

confidence: 99%

The contributions of muscarinic receptors and changes in plasma aldosterone levels to the anti-hypertensive effect of Tulbaghia violacea

Raji

Mugabo

Obikeze

2013

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…Plasma renin activity and plasma aldosterone concentration were measured by radioimmunoassay. 11 Subjects who had coronary artery disease, valvular heart disease, left bundle branch block, or other conduction disturbances were excluded. The clinical and hemodynamic characteristics in all subjects are summarized in the Table.…”

Section: Study Populationmentioning

confidence: 99%

Myocardial scintigraphic characteristics in patients with primary aldosteronism.

Abe

Hamada²,

Matsuoka³

et al. 1994

Hypertension

View full text Add to dashboard Cite

To evaluate the difference in myocardial damage between primary aldosteronism and untreated essential hypertension, we performed thallium-201 myocardial single-photon emission computed tomography in 10 patients with primary aldosteronism and 10 patients with essential hypertension who were matched for age, sex, blood pressure, and the severity of left ventricular hypertrophy for primary aldosteronism. From the analysis of thallium-201 myocardial scintigraphy, extent score was calculated. Extent score was significantly higher in primary aldosteronism than in essential hypertension (45.8±23J% versus 9.5±73%, P<.01). After operation, blood pressure significantly decreased, and the precordial voltages (SV,+RV 3 ) and left ventricular mass indexes were significantly reduced in patients with primary aldosteronism. Extent score was also significantly improved. These results suggest that despite the same severity of myocardial hypertrophy between primary aldosteronism and essential hypertension, the myocardial damage estimated by thallium-201 myocardial scintigraphy is more severe in primary aldosteronism than in essential hypertension. Extent score was useful for evaluation of the severity of myocardial damage in hypertensive patients. (Hypertension. 1994^3 [suppl I]:I-164-I-167.)Key Words • hyperaldosteronism • hypertension, essential • radionuclide imaging • hypertrophy, left ventricular P rimary aldosteronism, one of the secondary hypertensive diseases, is produced by excessive aldosterone excretion from adrenal adenoma. 1 Left ventricular hypertrophy in primary aldosteronism is thought to be due to hypertension, together with elevated circulating aldosterone levels. Left ventricular hypertrophy is the result of structural adaptation of the hypertensive heart and occurs in response to increased hemodynamic and metabolic factors such as catecholamine and angiotensin II.2 -6 Some studies have demonstrated that not only the progressive hypertrophy of myocytes but also interstitial fibrosis were observed in hypertensive heart, 3 -4 and the histological changes were dependent on arterial hypertension together with elevated circulating aldosterone levels. 5 These findings suggest that there is a difference in myocardial damage associated with hypertension between essential hypertension and primary aldosteronism.Recently, thallium-201 myocardial scintigraphy has been used as the most reliable method for the evaluation of myocardial damage in various heart diseases. 710The aim of this study was to elucidate with the use of thallium-201 myocardial scintigraphy whether a difference in myocardial damage exists between primary aldosteronism and essential hypertension. Methods Study PopulationTwenty normotensive control subjects, 10 patients with surgically proven primary aldosteronism, and 10 patients with untreated essential hypertension participated in this study, they were matched for age, sex, and blood pressure levels for primary aldosteronism. Blood pressure was measured with a From the Second Department of Inter...

show abstract

“…Por outro lado, como o captopril reduz a formação de angiotensina II, estimula a vasodilatação, melhora a função endotelial e reduz a ativação simpática (FAGARD et al, 1979;TARAZI et al, 1980;HIWADA;KOKUBU, 1981;VANDONGEN et al, 1981;FAGARD et al, 1982;JOHNSTON et al, 1982;KRAMER;TOPIC;MASSIE, 1982;MUIESAN et al, 1982;WENTING et al, 1982;MIZUNO et al, 1983;ITO et al, 1991;PROSTRAN et al, 1991;JIN;CHEN;WANG, 1997;DIAS DA SILVA et al, 2006)…”

Section: Tabela 13unclassified

“…A redução da pressão arterial promovida pelo captopril decorre, portanto, da redução da resistência vascular periférica (FAGARD et al, 1979;TARAZI et al, 1980;HIWADA;KOKUBU, 1981;FAGARD et al, 1982;KRAMER;TOPIC;MASSIE, 1982;MUIESAN et al, 1982;WENTING et al, 1982;ITO et al, 1991), que pode se acompanhar de manutenção (FAGARD et al, 1979;TARAZI et al, 1980;HIWADA;KOKUBU, 1981;MUIESAN et al, 1982;WENTING et al, 1982) ou mesmo de um pequeno aumento do débito cardíaco (FAGARD et al, 1979;FAGARD et al, 1982). Já o comportamento do débito cardíaco se associa ao aumento (FAGARD et al, 1979) ou manutenção (HASHIMOTO; HIWADA; KOKUBU, 1981) do volume sistólico e à redução (MUIESAN et al, 1982), manutenção (FAGARD et al, 1979;HIWADA;KOKUBU, 1981;KRAMER;TOPIC;MASSIE, 1982;MUIESAN et al, 1982;WENTING et al, 1982) ou ainda pequeno aumento (FAGARD et al, 1982) da frequência cardíaca. Cabe ressaltar, que a redução ou manutenção da frequência cardíaca frente à redução da pressão arterial não é uma resposta fisiológica esperada, visto que os barorreceptores deveriam tentar compensar a queda da pressão arterial, aumentando a frequência cardíaca (AIRES, 2008).…”

Section: Hipertensão Arterialunclassified

“…O captopril promove redução na formação de angiotensina II, redução da resistência vascular periférica (FAGARD et al, 1979;TARAZI et al, 1980;HIWADA;KOKUBU, 1981;FAGARD et al, 1982;KRAMER;TOPIC;MASSIE, 1982;MUIESAN et al, 1982;WENTING et al, 1982;ITO et al, 1991), diminuição da atividade nervosa simpática (DIAS DA SILVA et al, 2006), melhora da sensibilidade barorreflexa (DIAS DA SILVA et al, 2006) e melhora da função endotelial (JIN; CHEN; WANG, 1997). Desta forma, é possível que quando o exercício resistido é realizado pelo hipertenso em uso de captopril, a redução do retorno venoso ocorra da mesma forma que em indivíduos sem uso da medicação,…”

Section: Mecanismos Da Hipotensão Após Uma úNica Sessão De Exercíciosunclassified

See 1 more Smart Citation

Hipotensão pós-exercício resistido em homens hipertensos: influência do uso de captopril

Queiroz¹

View full text Add to dashboard Cite

Aos meus pais, Antenor e Ilda, por todo amor, carinho, empenho e paciência. A minha orientadora, Profª Cláudia Forjaz, pela paciência que sempre teve comigo, por estar sempre disponível para me orientar e por todas as oportunidades científicas que ela me proporcionou durante estes anos. Ressalto aqui minha admiração e respeito por esta pessoa que é um exemplo de competência e extrema dedicação. Ao meu orientador no exterior Profº Dr. Nicola Montano e à Dra. Eleonora Tobaldini por todos os ensinamentos, oportunidades e ajuda que me deram durante o período de estágio sanduíche no exterior. Ao pessoal do Laboratório de Hemodinâmica da Atividade Motora, que estava presente tanto nos momentos mais difíceis quanto nos mais engraçados (

show abstract

Effects of a single administration of captopril on hemodynamics and serum angiotensin converting enzyme activity, plasma renin activity and plasma aldosterone concentration in hypertensive patients.

Cited by 5 publications

References 13 publications

The contributions of muscarinic receptors and changes in plasma aldosterone levels to the anti-hypertensive effect of Tulbaghia violacea

The contributions of muscarinic receptors and changes in plasma aldosterone levels to the anti-hypertensive effect of Tulbaghia violacea

Myocardial scintigraphic characteristics in patients with primary aldosteronism.

Hipotensão pós-exercício resistido em homens hipertensos: influência do uso de captopril

Contact Info

Product

Resources

About