Effects of a Single Bout of Resistance Exercise on Calcium and Bone Metabolism in Untrained Young Males

Abstract

Although resistance exercise training appears to increase bone mineral density in the long term, a single bout of resistance exercise could paradoxically induce bone homeostasis disturbance, secondary to metabolic acidosis. To examine this, we obtained fasting blood and 24-hour urine samples from untrained male subjects for 5 subsequent days (control day, exercise day, and three post-exercise days), and investigated the effects of a single bout of resistance exercise on urinary calcium excretion and bone metabolism as indicated by sensitive biomarkers of bone formation and resorption. After an intense bout of resistance exercise, blood and urine became more acidic and renal net acid excretion significantly increased by 44% on the exercise day. Urinary calcium excretion significantly increased by 48% on the exercise day. Plasma procollagen type-I C-terminal concentration significantly decreased by 12% on the next day of the exercise and serum bone-specific alkaline phosphatase activity also significantly decreased by 13% and 9% on days 2 and 3, respectively, after the exercise. There was no significant change in serum osteocalcin concentration. Serum tartrate-resistant acid phosphatase activity significantly decreased by 15% on the day after the exercise and urinary deoxypyridinoline excretion decreased by 22% and 27% on days 1 and 3, respectively, after the exercise. These results suggest that the early response of bone to a bout of resistance exercise in untrained individuals was transient decreases in bone formation and resorption, whereas urinary calcium excretion increased.

Effects of a single bout of low intensity KAATSU resistance training on markers of bone turnover in young men

“…Our serum NTx findings are similar to those of Whipple et al (2004) who reported this bone marker significantly decreased 1 and 8 hours after an acute bout of high intensity resistance exercise. The lack of BAP response did not support our hypothesis which was based on previous studies which reported significant increases in BAP to acute aerobic (Wallace et al, 2000;Rudberg et al, 2000;Maimoun et al, 2006), acute KAATSU walk training (Beekley et al, 2005), and acute resistance exercise (Ashizawa et al, 1998).…”

“…The NTx response to KAATSU was not mediated by shifts in plasma volume. Key words: Bone biomarkers, Resistance exercise, Blood flow restriction acute bout of high intensity resistance exercise significantly increased resting serum levels of the bone formation marker, bone-specific alkaline phosphatase (BAP), 2-3 days after the exercise session, while the bone resorption marker (urinary deoxypyridinoline) transiently increased (Ashizawa et al, 1998). In young men, chronic resistance training was associated with significantly elevated BAP after 1 month, suggesting osteoblastic activity was increased in response to the high intensity resistance exercise (Fujimura et al, 1997).…”

Effects of plyometric exercise session on markers of bone turnover in boys and young men

“…Resistance training typically resulted in decreased bone resorption markers and unchanged bone formation markers, whereas endurance running typically resulted in increased markers of both bone formation and bone resorption (Ashizawa et al 1998;Brahm et al 1996;Langberg et al 2000;Lippi et al 2008;Malm et al 1993;Rogers et al 2011;Scott et al 2010Scott et al , 2011Scott et al , 2013Thorsen et al 1997;Welsh et al 1997;Whipple et al 2004;Ziegler et al 2005). Nonweight-bearing exercise, such as cycling, does not appear to result in a clear pattern of changes of biochemical markers of bone turnover (Guillemant et al 2004;Herrmann et al 2007;Pomerants et al 2008).…”

Impact of strenuous exercise on bone metabolism parameters among elderly

“…Similarly, Rudberg et al, [34] reported an increase in ALP levels after 30 -40 minutes of moderate running and Wallace et al, [35] found the same results after 2 hours of pedaling at 80% of VO2 max.2 However Ashizawa et al [36] observed a decrease in ALP, 2 to 3 days after weight training. On the other hand, one study showed that shortterm exercise has no effect on biochemical bone markers [30].…”