Effects of a Single-Dose of Pre-Emptive Pregabalin on Postoperative Pain and Opioid Consumption After Double-Jaw Surgery: A Randomized Controlled Trial

Ahişkalıoğlu, Ali; İnce, İlker; Aksoy, Mehmet; Yalçın, Ertan; Ahıskalıoğlu, Elif Oral; Kılınç, Adnan

doi:10.1016/j.joms.2015.09.008

Cited by 46 publications

(45 citation statements)

References 27 publications

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“…The efficacy of perioperative administration of gabapentinoids (gabapentin and pregabalin) has been investigated in various surgeries, and clinical studies have confirmed the potential of gabapentinoids as an adjuvant for pain treatment, mostly in acute and persistent postoperative pain. [ 5 , 13 – 16 ] Gabapentin is a useful adjunct for the management of postoperative pain since it provides analgesia through a different mechanism than opioids and therefore makes a reasonable addition to a multimodal analgesic treatment plan. [ 17 ] The use of gabapentin might be limited by its negative side effects, such as dizziness, somnolence, confusion, and ataxia.…”

Section: Discussionmentioning

confidence: 99%

Preoperative pregabalin prolongs duration of spinal anesthesia and reduces early postoperative pain

2016

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Background:The administration of oral pregabalin preoperatively has been reported to reduce acute postoperative pain. However, no clinical study to date has yet fully investigated whether or not pregabalin premedication affects sensory and motor blocks using spinal anesthesia and its effect upon early postoperative pain management. This prospective, randomized, and double-blind clinical study was designed to evaluate the efficacy of a single dose of pregabalin in terms of spinal blockade duration and its potential opioid-sparing effect during the first 24 hours subsequent to urogenital surgery.Methods:Forty-four patients scheduled for urogenital surgery under spinal anesthesia were randomly allocated to 2 groups: group C (no premedication; orally administered placebo 2 hours before surgery) and group P (orally administered 150 mg pregabalin 2 hours before surgery).Results:The duration of sensory and motor blockade was significantly prolonged in group P patients when compared with that in group C patients, and the pain scores at postoperative 6 and 24 hours were significantly lower in group P patients. Requests for analgesics during the first postoperative 24 hours were lower among group P patients.Conclusion:Premedication with a single dose of 150 mg pregabalin before surgery promoted the efficacy of intrathecal bupivacaine and improved postoperative analgesia in patients undergoing urogenital surgery under spinal anesthesia.

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Section: Discussionmentioning

confidence: 99%

Preoperative pregabalin prolongs duration of spinal anesthesia and reduces early postoperative pain

2016

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“…According to them, preoperative administration of 50mg tramadol In another study by Ahiskaliogluet al, forty patients were elected toundergo double jaw surgery. The study revealed that a single 150 mg dose of pre emptivepregabalin decreased postoperative opioid consumption in the first 24 [15] hours after double jaw surgery.…”

Section: Orthognathic Surgerymentioning

confidence: 92%

Opioids in the World of Oral and Maxillofacial Surgery- A Review

Muraleemohan

Shetty

Roy

et al. 2018

Journal of Health and Allied Sciences NU

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Pain control is one of the most difficult challenges in medicine and a key facet of disease management. The isolation of Morphine by Friedrich Sertürner in 1804 added an essential pharmacological tool in the treatment of pain and spawned the discovery of a new class of drugs known collectively as Opioid analgesics. To date, Morphine and other opioids remain essential analgesics for alleviating pain. However, their use is plagued by major side effects, such as analgesic tolerance (diminished pain-relieving effects), hyperalgesia (increased pain sensitivity), and drug dependence. Despite the potential side effects, opioids remain the pharmacological cornerstone of modern pain therapy. Opioids are particularly effective for treating acute moderate-to-severe pain after surgery or trauma. Just like other disciplines of Medicine, pain management is an integral part in Oral and Maxillofacial Surgery. The wide domain of diseases and the procedures involved in treating them, require profound analgesia for sound patient management. In order to achieve that , Opioid analgesics play a vital role for providing long term pain free period, thus enjoying a widespread use in this field. Critical to the employment of Opioid therapy are proper patient evaluation and use of comprehensive management strategies. If certain criteria are followed, administration of oral opioids may be a successful means of decreasing the patient's debilitating chronic pain to tolerable levels, enabling an improvement in the quality of life and return to function. This article is an attempt to review the commonly used opioids and their extensive application in routine maxillofacial surgery practice.

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“…Leukotriene, bradykinin, and platelet-activating factors are examples of inflammatory chemicals that start cascades leading to vascular dilatation, modified permeability, and accumulation of interstitial fluid causing edema. [3]…”

Section: Introductionmentioning

confidence: 99%

Effect of Low-intensity pulsed ultrasound on postorthognathic surgery healing process

Tehranchi

Badiee

Younessian

et al. 2017

Ann Maxillofac Surg

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Effects of a Single-Dose of Pre-Emptive Pregabalin on Postoperative Pain and Opioid Consumption After Double-Jaw Surgery: A Randomized Controlled Trial

Cited by 46 publications

References 27 publications

Preoperative pregabalin prolongs duration of spinal anesthesia and reduces early postoperative pain

Preoperative pregabalin prolongs duration of spinal anesthesia and reduces early postoperative pain

Opioids in the World of Oral and Maxillofacial Surgery- A Review

Effect of Low-intensity pulsed ultrasound on postorthognathic surgery healing process

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