Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris

Unger, Ellis F.; Gonçalves, Lino; Epstein, Stephen E.; Chew, Emily Y.; Trapnell, Carol Braun; Cannon, Richard O.; Quyyumi, Arshed A; Loscalzo, Francis; Stiber, Jonathan A.

doi:10.1016/s0002-9149(00)00787-6

Cited by 151 publications

(85 citation statements)

References 13 publications

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“…Also, single-bolus intracoronary FGF2 infusion showed transient beneficial effects, including reduction of angina symptoms, increase of treadmill tolerance and quality of life [237]. Transient beneficial effects were observed also in the phase II trial FIRST in which FGF2 was administered via intracoronary infusion [238].…”

Section: Fgfs and Therapeutic Angiogenesismentioning

confidence: 89%

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

Presta

Dell’Era

Mitola

et al. 2005

Cytokine & Growth Factor Reviews

1,129

870

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Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert their pro-angiogenic activity by interacting with various endothelial cell surface receptors, including tyrosine kinase receptors, heparan-sulfate proteoglycans, and integrins. Their activity is modulated by a variety of free and extracellular matrix-associated molecules. Also, the cross-talk among FGFs, vascular endothelial growth factors (VEGFs), and inflammatory cytokines/chemokines may play a role in the modulation of blood vessel growth in different pathological conditions, including cancer. Indeed, several experimental evidences point to a role for FGFs in tumor growth and angiogenesis. This review will focus on the relevance of the FGF/FGF receptor system in adult angiogenesis and its contribution to tumor vascularization. #

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Section: Fgfs and Therapeutic Angiogenesismentioning

confidence: 89%

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

Presta

Dell’Era

Mitola

et al. 2005

Cytokine & Growth Factor Reviews

1,129

870

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“…However, effective use of bFGF is not always achieved due to its rapid diffusion into body fluids and short half-life 19,20 . Furthermore, high doses of bFGF could cause severe side effects 21,22 . Therefore the need for a sustained exposure of growth factor at the defects site for better effect has led to the employment of delivery vehicles that facilitate a therapeutic, localized dose, provide a stabilizing matrix for the growth factor, and minimize toxic side effects usually associated with systemic administration.…”

Section: Discussionmentioning

confidence: 99%

Reconstruction of abdominal wall defects using small intestinal submucosa coated with gelatin hydrogel incorporating basic fibroblast growth factor

et al. 2014

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. Design of the study, critical revision. ABSTRACT PURPOSE:To construct a new biomaterial-small intestinal submucosa coated with gelatin hydrogel incorporating basic fibroblast growth factor, and to evaluate the new biomaterials for the reconstruction of abdominal wall defects. METHODS:Thirty six Sprague-Dawley rats were used in the animal experiments and randomly divided into three groups. The new biomaterial was constructed by combining small intestinal submucosa with gelatin hydrogel for basic fibroblast growth factor release. Abdominal wall defects were created in rats, and repaired using the new biomaterials (group B), compared with small intestinal submucosa (group S) and ULTRAPRO TM mesh (group P). Six rats in each group were sacrificed at three and eight weeks postoperatively to examine the gross effects, inflammatory responses, collagen deposition and neovascularization. RESULTS:After implantation, mild adhesion was caused in groups B and S. Group B promoted more neovascularization than group S at three weeks after implantation, and induced significantly more amount of collagen deposition and better collagen organization than groups S and P at eight weeks after implantation. CONCLUSION:Small intestinal submucosa coated with gelatin hydrogel incorporating basic fibroblast growth factor could promote better regeneration and remodeling of host tissues for the reconstruction of abdominal wall defects.Key words: Abdominal Wall. Biocompatible Materials. Intestinal, Fibroblast Growth Factor 2. Rats. Reconstruction of abdominal wall defects using small intestinal submucosa coated withgelatin hydrogel incorporating basic fibroblast growth factor

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“…In addition, recent studies performed in different tissues (esophagus, gastric mucosa, corpus luteum and red blood cells), have shown an important interaction between FGF-2 and the vasoactive renal systems, or FGF-2 and stress proteins induced by hypoxia (Schmerer et al, 2006;Unger et al, 2000;Carstens et al, 2000;Baguma-Nibasheka et al, 2007;Martins et al, 2008). This raises the possibility that FGF-2 may have a double role in kidney repair, by increasing the expression of repairing proteins, and by modulating the vasoactive systems of the kidney as well as the proteins related to the hypoxic stress response.…”

Section: Discussionmentioning

confidence: 99%

“…Both kidneys were exposed by a fl ank incision and both renal arteries were occluded with a non-traumatic vascular clamp for 30 minutes. Then, while clamps were in position, the left kidney was injected in the parenchymal medullary area with 200 μl of r-FGF (30 mg/ kg) (Villanueva et al, 2008;Unger et al, 2000) or FGFR2-ASO (112 μg/kg) (Villanueva et al, 2006b;Carstens et al, 2000) (preliminary experiments using methylene blue dye or Bouin's solution demonstrated that the volume used allowed extensive diffusion over the tissue); the right kidney was injected with the same volume of saline NaCl, 0.9 % (S), used as a vehicle for the oligonucleotides, and also used for control purposes. After injection clamps were removed, renal blood fl ow was reestablished and both incisions were sutured.…”

Section: Renal Ischemia/reperfusion Injurymentioning

confidence: 99%

Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure

et al. 2012

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Acute renal failure (ARF) can be caused by injuries that induce tissue hypoxia, which in turn can trigger adaptive or infl ammatory responses. We previously showed the participation of basic fi broblast growth factor (FGF-2) in renal repair. Based on this, the aim of this study was to analyze the effect of FGF-2 signaling pathway manipulation at hypoxia-induced protein levels, as well as in key proteins from the vasoactive systems of the kidney. We injected rat kidneys with FGF-2 recombinant protein (r-FGF) or FGF-2 receptor antisense oligonucleotide (FGFR2-ASO) after bilateral ischemia, and evaluated the presence of iNOS, EPO and HO-1, in representation of hypoxiainduced proteins, as well as COX-2, renin, kallikrein, and B2KR, in representation of the vasoactive systems of the kidney. A reduction in iNOS, HO-1, EPO, renin, kallikrein, B2KR, and in renal damage was observed in animals treated with r-FGF. The opposite effect was found with FGF-2 receptor down-regulation. In contrast, COX-2 protein levels were higher in kidneys treated with r-FGF and lower in those that received FGFR2-ASO, as compared to saline treated kidneys. These res ults suggest that the protective role of FGF-2 in the pathogenesis of ARF induced by I/R is a complex process, through which a differential regulation of metabolic pathways takes place.

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Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris

Cited by 151 publications

References 13 publications

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

Reconstruction of abdominal wall defects using small intestinal submucosa coated with gelatin hydrogel incorporating basic fibroblast growth factor

Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure

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