Effects of a single, large, intravenous iniection of dexamethasone

Czerwinski, Anthony W.; Whitsett, Thomas L.; Clark, Mervin L.

doi:10.1002/cpt1972135part1638

Cited by 35 publications

(12 citation statements)

References 3 publications

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“…Czerwinski et al . concluded that single large doses (2 mg kg −1 ) of dexamethasone were virtually without harmful side‐effects (11). In fact, the dose of dexamethasone (4 mg) in the present study was considerably less than those utilised by Czerwinski and therefore could be considered safe.…”

Section: Discussionmentioning

confidence: 47%

Effect of supraperiosteal injection of dexamethasone on postoperative pain

Mehrvarzfar¹,

Shababi²,

Sayyad³

et al. 2008

Aust Endodontic J

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Many patients suffer from mild, moderate or severe pain during or after root canal therapy. The purpose of this study was to evaluate the efficacy of supraperiosteal injection of dexamethasone into the periapical tissues to prevent postoperative pain associated with inflammation. In a double-blind, placebo-controlled clinical trial, 100 patients with moderate or severe pain who were referred to dental school of Tehran Islamic Azad University participated in this study. All patients had a tooth with clinical diagnosis of irreversible pulpitis. After administration of local anaesthesia, access cavity was prepared. Then, the root canals were instrumented to a minimum of a No. 25 K-file. One millilitre dexamethasone (8 mg 2 mL(-1)) or placebo was injected around the tooth. The severity of pain was assessed with regard to a modified visual analogue scale after 6, 12, 24 and 48 h. The data was analysed statistically with chi-square test. Dexamethasone was considerably effective on controlling the severity of pain during the first 24 h; in contrast, there was no difference between dexamethasone and placebo groups 48 h after the first appointment. A single dose of dexamethasone infiltrated around the apex of a tooth with irreversible pulpitis could be effective in reduction or prevention of postoperative endodontic pain during the first 24 h.

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Section: Discussionmentioning

confidence: 47%

Effect of supraperiosteal injection of dexamethasone on postoperative pain

Mehrvarzfar¹,

Shababi²,

Sayyad³

et al. 2008

Aust Endodontic J

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“…This has been demonstrated in an in vivo study by Czerwinski et al. (35) who concluded that single large doses (2 mg/kg) of dexamethasone were essentially without harmful side‐effects. This dosage is 10–25 times the amount advocated for endodontic pain attenuation.…”

Section: Pharmacokinetics and Relative Potencies Of Corticosteroidsmentioning

confidence: 77%

Consideration of steroids for endodontic pain

Marshall¹

2002

Endodontic Topics

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Up to 80% of endodontic patients who report with preoperative pain continue to experience some level of pain following the endodontic procedure. Since endodontic pain is often associated with chronic inflammation, the presence of bacterial by‐products, influx of primed immune cells and activation of the cytokine network and other inflammatory mediators, pain may be reduced by administration of glucocorticoid steroids. This review will include the pharmacology, pharmacodynamics and purported mechanisms of actions of steroids as well as their indications for endodontics, contraindications, dosages and side‐effects.

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“…Dexamethasone, on the other hand, is a nonparticulate steroid, and therefore it is currently considered the drug of choice in TFESI [29,32‐34]. As it has been widely used and studied since the 1950s the side effects of dexamethasone are well known, when administered intravenously or orally, to vary from headache and nausea, to allergic reactions and, in rare cases, anaphylaxis [35,36]. To our knowledge, there is no study published regarding side effects of dexamethasone administered in epidural steroid injections.…”

Section: Introductionmentioning

confidence: 99%

Generalized Pruritus as an Unusual Side Effect After Epidural Injection With Dexamethasone

Pimentel

Amadera

2014

PM&R

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A 51-year-old man with lumbar radiculopathy underwent a right L5 transforaminal epidural steroid injection with dexamethasone. One minute after the injection, the patient experienced severe pruritus and burning, which began in the groin and then spread throughout his body. The symptoms resolved completely after 1 minute, and the patient was discharged without any complications. Although there are a small number of publications reporting perineal pruritus after intravenous administration of dexamethasone, to our knowledge there is no report of a generalized reaction to an epidural dexamethasone injection such as the one described here.

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Effects of a single, large, intravenous iniection of dexamethasone

Cited by 35 publications

References 3 publications

Effect of supraperiosteal injection of dexamethasone on postoperative pain

Effect of supraperiosteal injection of dexamethasone on postoperative pain

Consideration of steroids for endodontic pain

Generalized Pruritus as an Unusual Side Effect After Epidural Injection With Dexamethasone

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