The purpose of this descriptive survey study was to identify the mediating effects of health perception between resilience and parenting burden among mothers of children with developmental disabilities. The health of children with developmental disabilities are dependent on their mothers' health. Subjects of the study were 108 mothers who have 3-9 years old children diagnosed with developmental disabilities. Self-report questionnaires were used to collect data. Data were analyzed with descriptive statistics, Pearson's correlation coefficient, and three-step mediated regression analysis using SPSS/WIN 22.0 programs. Mother's health perception had partial mediating effects in the relationship between resilience and parenting burden with explanatory power of 38% (Sobel test: Z=6.32, p<.001). This indicates that resilience not only has a significant effect on parenting burden, but also health perception has a significant effect on parenting burden. Therefore, to reduce the parenting burden of mothers with disabilities, it is reported that supportive forms and interviews that are not tied to formalism are effective in reducing parenting burden through the improvement of mothers' resilience.