Effects of a subunit vaccine (FlaA) and immunostimulant (CpG-ODN 1668) against Vibrio anguillarum in tilapia (Oreochromis niloticus)

Kwon, Hyuk Chu; Kang, Yue Jai

doi:10.1016/j.aquaculture.2015.12.005

Cited by 17 publications

(6 citation statements)

References 37 publications

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“…For example, dietary nucleotide exerted positive effects on growth performance of Astacus leptodactylus and L. vannamei (Andrino et al, 2012; Safari et al, 2014), β‐glucan, mannan‐oligosaccharide and astaxanthin could promote the growth of A. japonicas (Bai et al, 2013). CpG ODNs, a well‐known vaccine adjuvant in mammals, has also been used as a potential immunostimulant in aquatic animal (Kang & Kim, 2012; Kwon & Kang, 2016; Sun, Yue, et al, 2013), and some previous studies have reported that the sustained CpG ODNs stimulation could induce immunological tolerance (Mellor et al, 2005; Sun, Yue, et al, 2013; Volpi et al, 2013). However, whether the sustained CpG ODNs stimulation could affect the growth of aquatic animals was still unknown.…”

Section: Discussionmentioning

confidence: 99%

“…For example, the phagocytic activity and respiratory burst activities of kidney cells were increased post‐CpG ODNs stimulation in carp, Cyprinus carpio (Tassakka & Sakai, 2002). CpG ODNs 1668 could be applied as an adjuvant for immunization against Vibrio anguillarum in tilapia, Oreochromis niloticus (Kwon & Kang, 2016). After injection of CpG ODNs 1668 and 2216, olive flounder Paralichthys olivaceus showed enhanced resistance against viral haemorrhagic septicaemia virus infection (Kang & Kim, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Interval feeding of CpG ODN ‐supplemental diets enhanced growth in juvenile Chinese mitten crab, Eriocheir sinensis

Zhao

Wang

et al. 2022

Aquaculture Research

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CpG oligodeoxynucleotides (CpG ODNs) activate the immune system and act as an immunopotentiator against infectious diseases in aquatic animals, but the growthpromoting effect of CpG ODN was rarely reported in crustaceans. In the present study, CpG ODN (40 mg kg −1 ) was supplemented into the basic diet, and three feeding strategies including interval CpG ODN feeding (CI group), continuous CpG ODN feeding (CC group) and basic diet feeding (B group) were performed in Chinese mitten crab, Eriocheir sinensis. After 4 weeks of feeding, the weight gain and specific growth rate in CI group were significantly higher (p < 0.05) than that of CC group and B group.The moulting rate of CI group was also highest in CI group and lowest in CC group.Meanwhile, the alkaline phosphatase activity and Ca 2+ concentration that related to the shell formation, the amylase and pepsin activities on 14th day in CI group were all higher compared to other two groups. The glucose and glycogen values kept a relative high level from 14th day to 28th day in CI group compared to that in B group and CC group. In addition, the numbers of intestine fold and villus height were significantly higher (p < 0.05) than that of B group and CC group. More microvillus numbers, branches and goblet cells were observed in CI group. Taken together, these results demonstrated that the interval feeding strategy of CpG ODN supplemental diets probably promoted growth and might be a candidate strategy in the application of crab aquaculture.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interval feeding of CpG ODN ‐supplemental diets enhanced growth in juvenile Chinese mitten crab, Eriocheir sinensis

Zhao

Wang

et al. 2022

Aquaculture Research

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“…Alignani et al reported CpG-ODN-loaded ovalbumin (OVA) induced specific mucosal and systemic immune response in mice after oral administration [ 171 ]. CpG-ODN has different classes, such as CpG-ODN 2007 [ 172 ], CpG-ODN 1668 [ 173 ], and CpG-ODN 1826 [ 174 ], and has also shown potent mucosal adjuvant activity. Hjelm et al [ 175 ] used a panel of TLR agonists (PIC [TLR3], FLAG [TLR5], GARD [TLR7], CpG [TLR9], CpG-ISS [CpG 1018, alternate CpG motif, TLR9], and CL097 [TLR7/8]) as adjuvants combined with Norwalk VLPs (NV VLPs) coadministered to mice through intranasal and oral routes to determine the mucosal adjuvant activity of these immunomodulators.…”

Section: Non-biogenic Oral Vaccine Adjuvantsmentioning

confidence: 99%

Current Progress and Challenges in the Study of Adjuvants for Oral Vaccines

Yang

et al. 2023

BioDrugs

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Over the past 20 years, a variety of potential adjuvants have been studied to enhance the effect of oral vaccines in the intestinal mucosal immune system; however, no licensed adjuvant for clinical application in oral vaccines is available. In this review, we systematically updated the research progress of oral vaccine adjuvants over the past 2 decades, including biogenic adjuvants, non-biogenic adjuvants, and their multi-type composite adjuvant materials, and introduced their immune mechanisms of adjuvanticity, aiming at providing theoretical basis for developing feasible and effective adjuvants for oral vaccines. Based on these insights, we briefly discussed the challenges in the development of oral vaccine adjuvants and prospects for their future development.

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“…In addition to the use of whole-cell vaccines, we noticed that the development of DNA and subunit vaccines has been speeding up in recent years. Research and development of these two types of vaccines are mainly based on the immunological properties of V. anguilluram outer membrane proteins (OmpK, OmpU, OmpR, VAA) and flagellins (FlaA, FlaB) [ 63 , 64 ]. It was reported that a DNA vaccine based on the zinc metalloprotease EmpA already displayed gratifying results against V. anguillarum early in 2009 [ 65 ].…”

Section: Control and Prevention Strategies Of Vibriosmentioning

confidence: 99%

Strategies for Prevention and Control of Vibriosis in Asian Fish Culture

Wang

Yang

et al. 2022

Vaccines

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It is estimated that vibriosis account for about half of the economic losses in Asian fish culture. Consequently, the prevention and control of vibriosis is one of the priority research topics in the field of Asian fish culture disease. Relevant measures have been proposed to control some Vibrios that pose a threat to Asian fish culture, but there are currently only a few effective vaccines available to combat these Vibrios. The purpose of our review is to sum up the main prevention methods and the latest control strategies of seven Vibrio species that cause great harm to Asian aquaculture, including Vibrio harveyi, Vibrio vulnificus, Vibrio parahaemolyticus, Vibrio mimicus, Vibrio anguillarum, Vibrio alginolyticus and Vibrio cholerae. Strategies such as antibiotics, probiotics, bacteriophages, antimicrobials from plants and other natural sources, as well as vaccines, are compared and discussed here. We expect this review will provide some new views and recommendations for the future better prevention and control of vibriosis in Asian fish culture.

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Effects of a subunit vaccine (FlaA) and immunostimulant (CpG-ODN 1668) against Vibrio anguillarum in tilapia (Oreochromis niloticus)

Cited by 17 publications

References 37 publications

Interval feeding of CpG ODN ‐supplemental diets enhanced growth in juvenile Chinese mitten crab, Eriocheir sinensis

Interval feeding of CpG ODN ‐supplemental diets enhanced growth in juvenile Chinese mitten crab, Eriocheir sinensis

Current Progress and Challenges in the Study of Adjuvants for Oral Vaccines

Strategies for Prevention and Control of Vibriosis in Asian Fish Culture

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