Effects of a Tranquilizer and Two Antidepressants on Learned and Unlearned Behaviors

Syntheses of some new 1,5‐benzothiazepine derivatives and their ribofuranosides as antimicrobial agents

“…The IR spectra were recorded in KBr pellets on a NICOLET-MEGNA FT-IR 550 spectrophotometer. The 1 H NMR spectra were obtained on an FX 90Q JEOL spectrometer SCHEME 1 in CDCl 3 /DMSO-d 6 , and 13 C NMR spectra were recorded in DMSO solution, using TMS as an internal standard (chemical shift in δ). The purity of compounds was checked by TLC using gel "G" as adsorbent, and visualization was accomplished by UV light/iodine.…”

“…Many phar- macological compositions of 1,5-benzothiazepines have been patented [4,5] and some of the wellknown drugs are thiazesim [6], diltiazem [7], and clentiazem [8]. Krapcho et al [9] have also studied the ability of 1,5-benzothiazepine derivatives to function as a CNS depressant.…”

Syntheses of potentially bioactive [1,2,4]oxadiazolo[5,4‐d]benzothiazepines by 1,3‐dipolar cycloaddition

“…In recent years, a large number of 1,5-benzothiazepine derivatives containing anticancer activity [9,10], hemodynamic effects [11], antiulcer activity [12,13], and spasmolytic activities [14][15][16][17][18] have also been reported. Some of the 1,5-benzothiazepine derivatives were also used clinically for CNS disorders which include quetiapine fumarate and thiazesim [19][20][21].…”

Friedel-Crafts chemistry. Part 50. Convergent and diversity-oriented constructions of polycyclic quinolines via Friedel-Crafts and Beckmann ring enlargement approaches

“…2 Literature perusal of pharmacological studies of such moieties reveals that these compounds possess immense chemotherapeutic significance and are present as the core in a variety of drugs 3 ( Fig. 1), such as Prothioconazole-thiazocine, Diltiazem, Clotiapine, Omapatrilat, Promazine, Mesoridazine and Quetiapine, and exhibit a wide spectrum of pharmacological activities such as anticoagulant, 4 antiarterisoclerotic, 5 antihypertensive, 6 antidepressant, 7 antihistaminic, 8 anticonvulsant, 9 antidopaminergic, 10 tranquilizer, 11 antidepressant, 12 antihypertensive, 13 calcium channel blocker, 14 blood-platelet-aggregation inhibitors 15 and antiallergic agents. 16 A search for the applied methods for synthesis of medium-sized N,S-heterocyclic systems demonstrated that several established protocols are in practice, and comprehensive reviews of the syntheses and biological activities of various benzo-condensed 1,3-, 1,4-, 1,5-thiazepine and thiazocine regioisomers have been published.…”